The Circulating Level of IL-1β in Patients with Age-related Macular Degeneration (AMD) in Yogyakarta: Characteristics to Disease Activity

Abstract

Age-related Macular Degeneration (AMD) is leading factors for blindness and impaired visual acuity in developed countries. It is importance to study the dynamic of cytokines concentration during the exudative event of AMD to contribute in the future drugs inventions. This research aims to investigate the IL-1β profiles in plasma of exudative AMD patients. In this cross-sectional study, blood plasma samples from 17 AMD patients and 23 age-matched were collected. Samples were examined for IL-1β inflammatory cytokines using a commercially available ELISA. Acquired data were log transformed to normalize the outlier prior student T-test (SPSS software). Based on recent research, there is a statistically difference of IL-1β among AMD patients and control. IL-1 β concentration were higher at control. Detection of high level of inflammatory cytokines supports a role for inflammation in AMD pathogenesis.