The circulating levels of CTRP5 and the ratio of CTRP1 to CTRP5 plasma levels are significant predictors for cIMT value in patients with type 2 diabetes

Majidi, Ziba; Omidifar, Abolfazl; Emamgholipour, Solaleh; Fard,; Shanaki, Mehrnoosh

doi:10.21203/rs.3.rs-20710/v1

Cited by 1 publication

(1 citation statement)

References 39 publications

(49 reference statements)

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“…CTRP1 and CTRP1/CTRP5 ratio were markedly higher in male AS patients with T2DM compared to controls, indicating that these CTRPs might have a causal role for cardio-metabolic risk in T2DM. In addition, the ratio of CTRP1 to CTRP5 in plasma is positively correlated with carotid intima-media thickness in the whole population (14). Lei, X. et al found the positive association between elevated expression of CTRP2 and BMI in obesity (16).…”

Section: Pro-atherosclerotic Markersmentioning

confidence: 98%

Multi-faceted roles of C1q/TNF-related proteins family in atherosclerosis

Guo,

Mao,

Liu

2023

Front. Immunol.

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Purpose of reviewC1q/TNF-related proteins (CTRPs) are involved in the modulation of the development and prognosis of atherosclerosis (AS). Here, we summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of AS. Currently, there is no specific efficacious treatment for AS-related diseases, therefore it is urgent to develop novel therapeutic strategies aiming to target key molecules involved in AS.Recent findingsRecently, mounting studies verified the critical roles of the CTRP family, including CTRP1-7, CTRP9 and CTRP11-15, in the development and progression of AS by influencing inflammatory response, modulating glucose and lipid metabolism, regulating endothelial functions and the proliferation of vascular smooth muscle cells (VSMCs).ConclusionsCTRP family regulate different pathophysiology stages of AS. CTRP3, CTRP9, CTRP12, CTRP13 and CTRP15 play a clear protective role in AS, while CTRP5 and CTRP7 play a pro-atherosclerotic role in AS. The remarkable progress in our understanding of CTRPs’ role in AS will provide an attractive therapeutic target for AS.

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Section: Pro-atherosclerotic Markersmentioning

confidence: 98%