Background: Building fires are the most common threatening and distressing hazard in hospitals. Fire is one of the top 10 hazards that threaten Iranian hospitals. Nevertheless, no study has been done on the features of fires in Iran hospitals. So, this study aimed to investigate the characteristics of fires taking place in Iranian hospitals. Materials and Methods: In this cross-sectional study, news related to fire broke out in Iranian hospitals was retrieved from the archive of 5 reputable Persian news agencies using the Persian search terms: “Fire”, “hospital”, and “clinic”. Quantitative content analysis was used to assess retrieved news text. Data gathered by the Emergency Operation Center of the Iranian Ministry of Health and Medical Education were also studied. Results: In total, 86 incident reports were assessed for the period spanning from 2005 to 2020, with more than half accessed just through reputable news agencies. The electrical short circuit was the most reported incident cause, and the medical care environment was the most reported place of incident. Twenty-five incident reports indicated that partial or complete emergency evacuation was executed. Conclusion: It is imperative to raise awareness about the lack of an integrated mechanism for registering such incidents. Future research can be conducted designing a critical registry system that collects, analyzes, and disseminates hospital incident data.