The Classic Critical Care Conundrum Encounters Precision Medicine*

Zimmerman, Jerry J.

doi:10.1097/pcc.0000000000003141

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…There is the 2013-−2017 life after pediatric sepsis evaluation (LAPSE) study that failed to identify an association between early corticosteroid therapy in children with septic shock and clinical and 1-month health-related quality of life outcomes (27, 28). There is also the 2015−2018 sepsis biomarker model (PERSEVERE)-II risk stratification study of pediatric septic shock, which had an opposite result to the LAPSE data and showed that corticosteroid administration was associated with increased mortality in a subgroup of children with high PERSEVERE-II risk score (29, 30). Hence, at present, we do not have a definitive answer about hydrocortisone.…”

Section: “Pccm Connections” For Readersmentioning

confidence: 99%

Editor’s Choice Articles for February

Tasker

2024

Pediatric Critical Care Medicine

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Section: “Pccm Connections” For Readersmentioning

confidence: 99%

Editor’s Choice Articles for February

Tasker

2024

Pediatric Critical Care Medicine

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“…The authors use these data to encourage future research on phenotype, risk stratification, and trajectory in patients with sepsis. In fact, this information adds to two narratives about sepsis within PCCM: the Pediatric Sepsis Biomarker and Risk Model (PERSEVERE-II) and outcome data (21)(22)(23)(24); and the analysis of "trajectory" in time series data (25,26). (4).…”

Section: Atreya Mr Bennett Td Geva a Et Al; Novel Data-driven Sepsis ...mentioning

confidence: 99%

Editor’s Choice Articles for June

Tasker

2024

Pediatric Critical Care Medicine

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“…This could ultimately lead to more targeted and effective treatments for sepsis patients. While there is still much work to be done before transcriptomic data can be widely used in clinical settings, the research in this area is promising and could have significant implications for sepsis diagnosis and treatment in the future [ 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression

et al. 2023

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It is evident that the admission of some patients with sepsis and septic shock to hospitals is occurring late in their illness, which has contributed to the increase in poor outcomes and high fatalities worldwide across age groups. The current diagnostic and monitoring procedure relies on an inaccurate and often delayed identification by the clinician, who then decides the treatment upon interaction with the patient. Initiation of sepsis is accompanied by immune system paralysis following “cytokine storm”. The unique immunological response of each patient is important to define in terms of subtyping for therapy. The immune system becomes activated in sepsis to produce interleukins, and endothelial cells express higher levels of adhesion molecules. The proportions of circulating immune cells change, reducing regulatory cells and increasing memory cells and killer cells, having long-term effects on the phenotype of CD8 T cells, HLA-DR, and dysregulation of microRNA. The current narrative review seeks to highlight the potential application of multi-omics data integration and immunological profiling at the single-cell level to define endotypes in sepsis and septic shock. The review will consider the parallels and immunoregulatory axis between cancer and immunosuppression, sepsis-induced cardiomyopathy, and endothelial damage. Second, the added value of transcriptomic-driven endotypes will be assessed through inferring regulatory interactions in recent clinical trials and studies reporting gene modular features that inform continuous metrics measuring clinical response in ICU, which can support the use of immunomodulating agents.

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The Classic Critical Care Conundrum Encounters Precision Medicine*

Cited by 5 publications

References 25 publications

Editor’s Choice Articles for February

Editor’s Choice Articles for February

Editor’s Choice Articles for June

Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression

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