The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection

Latini, Francesco; Hjortberg, Mats; Aldskogius, Håkan; Ryttlefors, Mats

doi:10.1155/2015/872645

Cited by 16 publications

(13 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11A, 11B, 11D, and 11E; Tables 1 and 2). 53,54 To our knowledge, this is the first report that shows the Li-Am fasciculus in both MR tractography and fiber dissection.…”

Section: Fig 4 Amentioning

confidence: 81%

“…The Li-Am fasciculus, connecting the limbic and visual systems, has been linked to developmental and individual differences in social cognition, and damage to this structure has been implicated in the propagation of occipital lobe epilepsy and deterioration of social cognition. 53,54,93 Damage to the anterior part of the optic radiations in this approach may result in superior homonymous quadrantanopsia. 124 Paramedian Supracerebellar-Transtentorial Approach.…”

mentioning

confidence: 99%

“…104,107 This approach requires a parahippocampal gyrus incision to reach the hippocampus and amygdala, which can damage the cingulum, fornix, and Li-Am fasciculus and may cause limbic system dysfunction with behavioral and cognitive changes (Table 3). 53,54,72,88 …”

mentioning

confidence: 99%

See 2 more Smart Citations

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

View full text Add to dashboard Cite

S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

show abstract

“…11A, 11B, 11D, and 11E; Tables 1 and 2). 53,54 To our knowledge, this is the first report that shows the Li-Am fasciculus in both MR tractography and fiber dissection.…”

Section: Fig 4 Amentioning

confidence: 81%

mentioning

confidence: 99%

See 1 more Smart Citation

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

View full text Add to dashboard Cite

show abstract

“…Intrahemispheric migrations were mainly between temporal and occipital, occipital and central, and frontal and temporal channels. These regions are known to be strongly interconnected by white matter pathways and are involved in seizure propagation . The subcortical nuclei‐mediated spreads were probably not involved in the EIMFS patients studied, since cortical‐subcortical pathways are implicated mainly in seizure generalization and in infantile spasms…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures

et al. 2018

View full text Add to dashboard Cite

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy. Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. After detection of seizure onset and termination, spatiotemporal characteristics were quantified. Seizure propagation dynamics were analyzed using chronograms and phase coherence. Results: In patients with EIMFS, seizures started and were localized predominantly in temporal and occipital areas, and evolved with a stable frequency (4-10 Hz). Inter-and intrahemispheric migrations were present in 60% of EIMFS seizures with high intraindividual reproducibility of temporospatial dynamics. Interhemispheric migrating seizures spread in 71% from temporal or occipital channels to the homologous contralateral ones, whereas intrahemispheric seizures involved mainly frontotemporal, temporal, and occipital channels. Causality links were present between ictal activities detected under different channels during migrating seizures. Finally, time delay index (based on delays between the different ictal onsets) and phase correlation index (based on coherence of ictal activities) allowed discrimination of EIMFS and non-EIMFS seizures with a specificity of 91.2% and a sensitivity of 84.4%. Significance: We showed that the migrating pattern in EIMFS is not a random process, as suggested previously, and that it is a particular propagation pattern that follows the classical propagation pathways. It is notable that this study Wendling and Nabbout contributed equally to the manuscript.

show abstract

“…1 and 2) to emphasize the surgicalanatomical point of view for students with no previous understanding of neurosurgical brain anatomy. The specimens were used for education as a part of a larger research project on white matter dissection as previously described in other articles [16][17][18][19].…”

Section: Activitymentioning

confidence: 99%

Teaching Anatomy to Neuroscientific Health-Care Professionals: Are They Receiving the Best Anatomical Education?

Latini

Ryttlefors

2019

Med.Sci.Educ.

Self Cite

View full text Add to dashboard Cite

University neuroanatomical courses seldom teach the anatomical-functional connectivity of the brain. White matter dissection improves understanding of brain connectivity, but until now has been restricted to neurosurgeons and in some cases to medical students, never to health-care non-medical professionals. Our aim was to teach white matter anatomy to medical and non-medical students to evaluate this technique in groups with different education. A standardized lab demonstration of white matter anatomy was performed with high appreciation rate in both groups, suggesting a suboptimal neuroanatomical education provided by basic course. We encourage to include this technique of teaching brain anatomy into basic neuroanatomical courses to improve the level of comprehension and competence in all health-care staff within the field of neuroscience.

show abstract

The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection

Cited by 16 publications

References 54 publications

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures

Teaching Anatomy to Neuroscientific Health-Care Professionals: Are They Receiving the Best Anatomical Education?

Contact Info

Product

Resources

About