The Classification of Retinal Detachment with Proliferative Vitreoretinopathy

Hilton, George F.; Machemer, Robert; Michels, R.; Okun, Edward; Schepens, Charles L.; Schwartz, Ariah

doi:10.1016/s0161-6420(83)34588-7

Cited by 653 publications

(93 citation statements)

References 9 publications

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“…Therefore, in this study we investigated vitreous concentrations of HGF and VEGF in patients with grade D PVR, according to international classification [29], PDR, and IMH, and examined the relationship between two angiogenic factors in the same samples.…”

Section: Introductionmentioning

confidence: 99%

Non-Paralleled Increase of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in the Eyes with Angiogenic and Nonangiogenic Fibroproliferation

Umeda¹,

Ozaki²,

Hayashi³

et al. 2002

Ophthalmic Res

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Vascular endothelial growth factor (VEGF) has been known as principal angiogenic factor in vasculogenesis, tumor angiogenesis and ocular angiogenesis. Currently, hepatocyte growth factor (HGF) has been reported to play a major role in ocular angiogenesis. We studied distribution of both growth factors in angiogenic and non-angiogenic fibroproliferation to determine the correlation of VEGF and HGF in retinal angiogenesis. Concentrations of VEGF and HGF molecules in vitreous samples from 27 eyes with angiogenic proliferative diabetic retinopathy (PDR) and 9 eyes with non-angiogenic proliferative vitreoretinopathy (PVR) were measured by enzyme-linked immunosorbent assay (ELISA). Vitreous samples with idiopathic macular role (IMH) served as a control. Concentrations of VEGF in the angiogenic PDR were 4.3 ± 5.8 ng/ml (mean ± SD), and were significantly higher than in non-angiogenic PVR (0.5 ± 0.1 ng/ml). No significant differences were observed on VEGF concentrations between PVR to control. On the contrary, HGF concentrations were significantly higher in PVR (22.5 ± 21.8 ng/ml) than in control (6.9 ± 5.2 ng/ml), those of PDR (24.0 ± 16.3 ng/ml) were also significantly higher than control. Among PDR samples, VEGF concentration was significantly higher than in the subgroup with higher angiogenic activity represented by iris neovascularization, although there were no significant differences on HGF concentration between the subgroups. Focal increases in HGF on fibroproliferation in the eye regardless of the involvement of angiogenesis were not in remarkable relation with angiogenic activity, unlike VEGF. These data suggested a more extensive role of HGF than VEGF strictly related to angiogenesis.

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Section: Introductionmentioning

confidence: 99%

Non-Paralleled Increase of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in the Eyes with Angiogenic and Nonangiogenic Fibroproliferation

Umeda¹,

Ozaki²,

Hayashi³

et al. 2002

Ophthalmic Res

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“…Traditionally, these flow into the so called 17 proliferative vitreoretinopathy [PVR] classification [17–19] and a variety of surgical consequences from this classification. Since in a proliferative diabetic retinopathy (PDR), there are many similarities with the PVR process; Kroll et al introduced “fPDVR” in 2007 [19] which will be used in this work as P(D)VR from now.…”

Section: Introductionmentioning

confidence: 99%

Key Factors to Improve the Outcome of Retinal Reattachment Surgery in Proliferative Vitreoretinopathy and Proliferative Diabetic Retinopathy

Deuchler

Ackermann

Singh

et al. 2017

Journal of Ophthalmology

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Introduction For management of complicated retinal detachments, a pars plana vitrectomy with temporary silicone oil (SO) fill is the method of choice. According to literature, the retinal redetachment rate varies between <10% and >70% with around 36% in our own group (retrospective data analysis, n = 119 eyes). Methods The main goal was to reduce the retinal redetachment rate. Standard operating procedures (SOPs) and evaluation protocols (EVALPs) were developed to prospectively analyse risk factors. Lab analysis of SO was performed, and the role of surgical experience was evaluated and investigated with Eyesi®. Results We achieved a significant reduction of the retinal redetachment rate (to 6.80%, n = 101, p = 0.002). After surgery with SO injection, neither further membrane peeling (in 16.5%) nor retinal laser coagulation (in 100%) during revision surgery had a significant effect on the reattachment rate (p = 0.167, p = 0.23), while extensive additional laser coagulation reduced visual acuity (p = 0.01). A 3-port approach had to be set up to complete SO removal. A difference in success rate depending on surgical experience was confirmed, and the performance in Eyesi correlated with that in the patients' eye. Conclusions A SOP- and EVALP-based management and new strategies to secure the surgical performance seem to be essential for successful surgery.

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“…Complex RDs with both superior and inferior breaks and/or proliferative vitreoretinopathy (PVR) [3] present a challenge, as neither type of oil provides adequate tamponade [4]. We report a series of such cases who received tamponade with both types of oil simultaneously to enable tamponade of both superior and inferior retina.…”

Section: Introductionmentioning

confidence: 99%

Ratios for double silicone oil Endotamponade – in vitro observations may assist with ratio selection

MacGregor¹,

Jonas²,

Hanifudin³

et al. 2017

BMC Ophthalmol

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BackgroundSilicone oil tamponade is more frequently reserved for cases of complex retinal detachment. We describe the effects of different variations in oil ratios with the relatively unknown technique of double oil tamponade.MethodsRetrospective case note review of nine patients with complex rhegmatogenous retinal detachment (RD). All cases had both superior and inferior breaks, mostly with associated proliferative vitreoretinopathy (PVR). All cases were treated with pars plana vitrectomy (PPV) and a double silicone oil endotamponade (DSOE) of both heavy silicone oil and conventional ‘light’ silicone oil. Ratios were varied to suit different RD configurations. In vitro observations were studied to help direct these decisions.ResultsAnatomical success was achieved in all cases. Common complications were the same as those seen in single oil tamponade (elevated intraocular pressure, cystoid macular oedema (CMO), cataract and posterior capsule opacification. No single case of recurrent RD was seen whilst mixed oil remained in situ.ConclusionsDouble silicone oil endotamponade is a safe and effective treatment for complex retinal detachments with superior and inferior breaks. Differences in oil ratios can be tailored to best fit the distribution of retinal pathology. In vitro observations may help to inform these choices.

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The Classification of Retinal Detachment with Proliferative Vitreoretinopathy

Cited by 653 publications

References 9 publications

Non-Paralleled Increase of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in the Eyes with Angiogenic and Nonangiogenic Fibroproliferation

Non-Paralleled Increase of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in the Eyes with Angiogenic and Nonangiogenic Fibroproliferation

Key Factors to Improve the Outcome of Retinal Reattachment Surgery in Proliferative Vitreoretinopathy and Proliferative Diabetic Retinopathy

Ratios for double silicone oil Endotamponade – in vitro observations may assist with ratio selection

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