The Clathrin adaptor AP-1 and the Rab-stabilizing chaperone Stratum act in two parallel pathways to control the activation of the Notch pathway in <i>Drosophila</i>

Bellec, Karen; Gicquel, Isabelle; Borgne, Roland Le

doi:10.1101/645580

Cited by 1 publication

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This ligand-Notch receptor interaction triggers a cascade of molecular signaling that instigate the development and maturity of the stem cells during development and also in adulthood (5,6). In neuronal stem cells (NSCs), Notch signaling is tissue-dependent and modulates neural processes including coupling of neuronal growth, differentiation and development of astrocytes (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Javed

Khan

Raza

et al. 2021

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Notch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates process of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are being orchestrated by the Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive role in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in development of nervous system and how this versatile pathway interplay with microRNAs in glioblastoma. This review sheds light on interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by the Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Javed

Khan

Raza

et al. 2021

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

The Clathrin adaptor AP-1 and the Rab-stabilizing chaperone Stratum act in two parallel pathways to control the activation of the Notch pathway in Drosophila

Abstract: Drosophila sensory organ precursors divide asymmetrically to generate pIIa/pIIb cells whose

Cited by 1 publication

References 38 publications

Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Contact Info

Product

Resources

About