The ClearPET™ project: development of a 2nd generation high-performance small animal PET scanner

Ziemons, K.; Auffray, E.; Barbier, R.; Brandenburg, G.; Bruyndonckx, Peter; Choi, Yong; Christ, Daryl; Costes, Nicolas; Déclais, Y.; Devroede, O.; Dujardin, Christophe; Fedorovd, A.; Heinrichs, U.; Korjik, M.; Krieguer, M.; Kuntner, Claudia; Largeron, G.; Lartizien, Carole; Larue, H.; Lecoq, P.; Léonard, Sarah; Marteau, J.; Morel, C.; Mosset, J.-B.; Parl, C.; Pédrini, C.; Petrosyan, A.; Pietrzyk, U.; Rey, M.; Saladino, S.; Sappey-Marinier, Dominique; Simon, L.; Streun, M.; Tavernier, S.; Vieira, J.-M.

doi:10.1016/j.nima.2004.08.032

Cited by 129 publications

(62 citation statements)

References 3 publications

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“…The ClearPET project [37] In order to leverage the synergy available within Crystal Clear for further applications, the collaboration decided to focus on medical imaging instrumentation; in particular, to use its high energy physics expertise in integrating multi-thousand-channel detectors to develop a compact highperformance scanner for Positron Emission Tomography (PET), using new kinds of crystals and photon detectors, and low-noise and fast signal processing. The collaboration first proposed to build a PET scanner for small animals, the ClearPET, together with several biologists and medical groups.…”

Section: Paul Lecoqmentioning

confidence: 99%

Knowledge and Technology: Sharing With Society

Benvenuti¹,

Sutton²,

Wenninger³

2017

Advanced Series on Directions in High Energy Physics

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Education and basic research are large costs to society, which governments, in general, accept as a necessary long-term investment. Still, it is fair to ask how this investment can be used to the best overall benefit for society.Many excellent reports and talks [1][2][3][4][5] describe how basic research, motivated by "curiosity" -the desire to extend our understanding of nature -contributes as much to innovation as do the applied sciences, which focus on solving specific problems. Both stimulate industry and advance technology.Consider the core technologies of high energy particle physics. Accelerator applications range from killing bacteria and treating cancer, to welding and cutting, hardening materials, reducing harmful gas emissions from thermal power plants, and much more. Particle detectors are not only ubiquitous in medical imaging; they are also used, for example, by volcanologists and archaeologists to image sites of potential interest. Computer simulation toolkits developed for particle physics have become essential in other fields, including medicine, aerospace, and nano-science.Complex instruments and cutting-edge technologies are required for the construction and operation of accelerators and intricate detectors, as well as for managing the wealth of data they produce. When existing technologies are inadequate to meet requirements, developments are triggered that often give rise to technological innovations. Most famously, the World Wide Web, which was invented at CERN in the late 1980s to allow automatic sharing of information for scientists, has revolutionized global communication with enormous social and economic impact. Three decades later, data-handling and analysis needs for research at the LHC continue to push forward the evolution of worldwide distributed grid computing, bringing benefits to bio-computing and health sciences, astrophysics, environmental studies, and others.

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Section: Paul Lecoqmentioning

confidence: 99%

Knowledge and Technology: Sharing With Society

Benvenuti¹,

Sutton²,

Wenninger³

2017

Advanced Series on Directions in High Energy Physics

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“…An example of this type of system is the ClearPET/XPAD shown in Fig. 13.6 which combines a modifi ed design of the ClearPET preclinical PET scanner [ 63 ] with the XPAD hybrid pixel X-ray detector to allow simultaneous dual-modality PET/CT imaging [ 64 ]. Due to the simultaneous acquisition of PET and CT data, an important consideration for this design is the shielding of PET detector blocks to prevent their saturation by the low energy scattered X-ray CT photons.…”

Section: Integrated Pet/ct Imaging Systemsmentioning

confidence: 99%

Dual-Modality Preclinical PET/CT Instrumentation

Goertzen

Zaidi

2014

Molecular Imaging of Small Animals

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“…The first of these represents the variance in the number of photons generated per scintillation event, the second represents the added variance due to the conversion of scintillation photons to primary e-h pairs in the APD, the third represents the APD multiplication variance, and the fourth represents the contribution of electronic noise [15]: (2) where is the FWHM energy resolution, and ENC is the equivalent noise charge of the detector-amplifier system referred to the preamplifier input.…”

Section: A Energy Resolutionmentioning

confidence: 99%