The Clinical and Biologic Significance of Abnormal Lipid Profiles in Patients with Myelodysplastic Syndromes

Abstract

Serum lipid profiles were obtained in 108 patients with myelodysplastic syndrome (MDS) and compared to 28 healthy volunteers. Serum cholesterol and low-density and high-density lipoproteins (LDL and HDL) were found to be significantly lower in MDS patients than in normals (p = 0.0001, 0.0038 and 0.037, respectively). This difference was significant for all MDS categories. Serum cholesterol and HDL were negatively related to biopsy cellularity (p = 0.001 and 0.0001, respectively), and serum triglycerides were negatively related to labeling index (p = 0.0003). No differences were noted in the lipid profiles of MDS patients with normal versus abnormal karyotypes. However, low-risk MDS patients with abnormal karyotypes had significantly lower triglyceride levels compared with the high-risk patients (p = 0.027), as did low-risk patients with normal cytogenetics (p = 0.015). Serum HDL levels were significantly higher for the low-risk group with normal cytogenetics as well (p = 0.003). We conclude that serum cholesterol, LDL, and HDL are significantly reduced in MDS patients, probably indicating excessive intracellular lipid biosynthesis in the expanding clone. These relatively simple measurements could serve as important prognostic markers and reliable indicators of disease activity in individual patients. Prospective studies to determine their utility as independent variables that guide the need for active therapeutic intervention are warranted.

Hypocholesterolemia in chronic anemias with increased erythropoietic activity

“…Hypocholesterolemia has been described in various hematological disorders [1], including thalassemia major [2], thalassemia intermediate [3], sickle cell disease [4], glucose-6-phosphate dehydrogenase (G6PD) deficiency [5], spherocytosis [6], aplastic anemia [7], and myelodysplastic syndrome [8]. The pathophysiology of the hypocholesterolemia in these settings remains obscure, although several mechanisms have been proposed: plasma dilution due to anemia, increased cholesterol requirement associated with erythroid hyperplasia, macrophage system activation with cytokine release, increased cholesterol uptake by the reticuloendotial system, and liver injury secondary to iron overload [2,3].…”

<i>Clerodendron inerme</i> Protects Cellular Integrity During 7,12- Dimethylbenz[A]-Anthracene Induced Hamster Buccal Pouch Carcinogenesis

“…Lipids, an integral part of biomembrane, are essential for several biological functions including normal cell growth and division, as well as for cellular proliferation (Allampallam et al, 2000). Although abnormalities of lipids have been implicated in the pathogenesis of cardiovascular diseases, altered levels of lipids and lipoproteins in circulation have also been found to be associated with the etiopathogenesis of several cancers Kolanjiappan et al, 2003).…”

Role of CYP2E1 and NQO1 polymorphisms in oxidative stress derived cancer in Thais with and without dyslipidemia

“…Hypercholesterolemia can induce the production of reactive oxygen species (ROS), such as superoxide anion, via enzymes including the oxidase for the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and xanthine oxidase, and other sources of ROS from mitochondria [4]. Some investigators have reported an association between levels of plasma or serum lipids and lipoproteins, and various types of cancers [5][6][7]. Individual susceptibility to cancer can result from several host factors, especially differences in the activity of xenobioticmetabolizing enzymes [8].…”