The clinical and epidemiological characteristics of a series of patients living with HIV admitted for COVID-19 in a district hospital

Mnguni, Ayanda Trevor; Schietekat, Denzil; Ebrahim, Nabilah; Sonday, Nawhaal; Boliter, Nicholas; Schrueder, Neshaad; Gabriels, Shiraaz; Sigwadhi, Lovemore N.; Zemlin, Annalise E; Chapanduka, Zivanai C.; Ngah, Veranyuy D.; Yalew, Anteneh; Jalavu, Thumeka P.; Abdullah, Ibtisam; Tamuzi, Jacques L.; Tembo, Yamanya; Davies, Mary‐Ann; English, René; Nyasulu, Peter

doi:10.1186/s12879-023-08004-6

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…In a high HIV and TB burden setting, COVID-19 has been associated with high mortality among people living with HIV. 60 A divergence is noted in the antiretroviral effective coverage figures between the modelled Thembisa 4.5 estimates and the routine coverage from webDHIS (Table 13), which could be the result of the momentum lost during the COVID-19 period.…”

Section: Hiv and Aidsmentioning

confidence: 99%

Health and related indicators 2022

Day

Gray

2023

South African Health Review

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Background This chapter aims to provide a repository of data, focusing on the national and provincial levels, that describes the broad status of the South African health system (socio-demographic indicators and determinants and health status indicators, as well as health service indicators). It examines the available health information data sources in South Africa, with a particular focus on whether they have been strengthened during and after the acute phase of the COVID-19 pandemic. The broader context for this chapter lies in the desire to see the lessons learned from the COVID-19 pandemic translated into systemic changes that advance the reform of South Africa’s fragmented health services and hasten the attainment of effective and sustainable universal health coverage. Methods Data were sourced primarily from national routine data sources, but also captured from major surveys and global reports. Using monthly routine data sources, the difference between expected and actual routine measures were calculated and expected trends were forecast. These graphs enabled the depiction of the changes that occurred pre- and post-COVID in South Africa for key health indicators. Conclusions Progress is discernible, but there is also evidence of back-sliding, of a revision to previous positions, and therefore a need to refocus attention on important lessons, lest they be lost. Recommendations Strong health information systems should be the foundation on which evidence-based decisions can be made to support strong governance and leadership, where human resources for health are also supported and healthcare funding is prioritised.

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Section: Hiv and Aidsmentioning

confidence: 99%

Health and related indicators 2022

Day

Gray

2023

South African Health Review

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“…A study done in Cape Town, South Africa compared the rate of hospitalization in different stages of HIV disease. Their study stated that the rate of hospitalization was 69% higher in stage 4 (CD4 less than 200 cells/ml) and 29 % higher in stage 2 (CD4 count was 200-499) compared to stage 1 (CD4 counts > 500 cells/ml) [ 60 ].…”

Section: Reviewmentioning

confidence: 99%

Double Trouble Co-Infections: Understanding the Correlation Between COVID-19 and HIV Viruses

Abbasi,

Noor,

Mylavarapu

et al. 2023

Cureus

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A global outbreak of coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mounted a substantial threat to public health worldwide. It initially emerged as a mere outbreak in Wuhan, China, in December 2019 and quickly engulfed the entire world, evolving into a global pandemic, consuming millions of lives and leaving a catastrophic effect on our lives in ways unimaginable. The entire healthcare system was significantly impacted and HIV healthcare was not spared. In this article, we reviewed the effect of HIV on COVID-19 disease and the ramifications of the recent COVID-19 pandemic over HIV management strategies. Our review highlights that contrary to the instinctive belief that HIV should render patients susceptible to COVID-19 infection, the studies depicted mixed results, although comorbidities and other confounders greatly affected the results. Few studies showed a higher rate of in-hospital mortality due to COVID-19 among HIV patients; however, the use of antiretroviral therapy had no consequential effect. COVID-19 vaccination was deemed safe among HIV patients in general. The recent pandemic can destabilize the HIV epidemic control as it hugely impacted access to care and preventive services and led to a marked reduction in HIV testing. The collision of these two disastrous pandemics warrants the need to materialize rigorous epidemiological measures and health policies, but most importantly, brisk research in prevention strategies to mitigate the combined burden of the two viruses and to battle similar future pandemics.

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