The clinical and genetic findings in a Chinese family with Axenfeld-Rieger syndrome

Cheng, Lu; Zhang, Yinong; Ding, Yibing; Yuan, Zhilan; Han, Xiao

doi:10.1016/j.heliyon.2022.e12543

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Some genes involved in left-right patterning contribute to facial asymmetry of the CLP spectrum (33). For example, PITX2 contributes to tooth initiation, maxillary hypoplasia, laterality, and is causing Axenfeld-Rieger syndrome (32,34). These results shed light on the molecular genetic relationships between tooth, face, and left-right patterning.…”

Section: Supernumerary Teethmentioning

confidence: 96%

Prevalence of tooth agenesis and supernumerary teeth related to different Thai cleft lip and cleft palate populations

Aung,

Pungchanchaikul,

Pisek

et al. 2023

Preprint

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Background Pattern of dental anomalies encountered in cleft patients shows subtle signs of genetic involvement. This study aimed to evaluate the prevalence and pattern of tooth agenesis and supernumerary teeth in Thai cleft population according to the cleft type. Methods Data collected from patients with cleft lip and palate, who had been treated at Tawanchai Cleft Center, Khon Kaen University, Thailand, available during year 2012–2022, were investigated. Records from 194 patients with non-syndromic clefts met the inclusion criteria. Standard dental records, and at least either orthopantomogram (OPG) or cone beam computed tomography (CBCT), were examined. Statistical analysis was performed using chi-square and binominal test (p ≤ 0.05). Results Prevalence of tooth agenesis was higher (77.3%) than that of supernumerary teeth (5.7%) and was more common in bilateral cleft lip and palate (BCLP) (88.1%) than in unilateral cleft lip and palate (UCLP) (72.6%) (p = 0.017). The upper lateral incisor was more frequently affected (46.4%), followed by the upper second premolar. The number of missing teeth observed on the left side was significantly higher. Patients with left UCLP (ULCLP) had the highest prevalence of tooth agenesis. A total of 41 tooth agenesis code (TAC) patterns was found. The prevalence of supernumerary teeth was comparable with 6.6% of ULCLP, 5.1% of BCLP, and 4.5% of URCLP. Tooth-number anomalies were observed more often in the BCLP and were most likely to occur on the left side of the maxilla. Both types of anomalies could be featured in a small proportion of cleft patients. Conclusions More than half of the patients with non-syndromic cleft lip and palate in this study, presented with tooth-number anomalies. Tooth agenesis was approximately 10-time more prevalent than supernumerary teeth. Tooth agenesis was likely to appear on the left-side of the maxilla regardless of the laterality of the cleft.

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Section: Supernumerary Teethmentioning

confidence: 96%