2023
DOI: 10.1093/noajnl/vdac110
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The clinical and genomic features of seizures in meningiomas

Abstract: Meningiomas are the most common central nervous system tumors. Although these tumors are extra-axial, a relatively high proportion (10%–50%) of meningioma patients have seizures that can substantially impact the quality of life. Meningiomas are believed to cause seizures by inducing cortical hyperexcitability that results from mass effect and cortical irritation, brain invasion, or peritumoral brain edema. In general, meningiomas that are associated with seizures have aggressive features, with risk factors inc… Show more

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Cited by 3 publications
(8 citation statements)
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“…Pathogenetic mechanisms driving tumor-related epilepsy remain complex and include aberrant neuronal migration, changes in synaptic vesicles and glial gap-junction coupling alterations [ 6 , 9 , 20 , 23 ]. On a cellular level, morphologic changes lead to a higher concentration of excitatory voltage-dependent Na + , Ca ++ and glutamate receptors, diminishing inhibitory synapses and propagating excitatory influences leading to cortical hyperexcitability [ 5 , 6 ]. Moreover, brain invasion has been shown to be associated with preoperative seizures, leading to a disruption of the pial-glial basement membrane, potentially inducing astrocytic responses and altering the tumor microenvironment similar to primarily intra-axial malignancies [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Pathogenetic mechanisms driving tumor-related epilepsy remain complex and include aberrant neuronal migration, changes in synaptic vesicles and glial gap-junction coupling alterations [ 6 , 9 , 20 , 23 ]. On a cellular level, morphologic changes lead to a higher concentration of excitatory voltage-dependent Na + , Ca ++ and glutamate receptors, diminishing inhibitory synapses and propagating excitatory influences leading to cortical hyperexcitability [ 5 , 6 ]. Moreover, brain invasion has been shown to be associated with preoperative seizures, leading to a disruption of the pial-glial basement membrane, potentially inducing astrocytic responses and altering the tumor microenvironment similar to primarily intra-axial malignancies [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
“…On a cellular level, morphologic changes lead to a higher concentration of excitatory voltage-dependent Na + , Ca ++ and glutamate receptors, diminishing inhibitory synapses and propagating excitatory influences leading to cortical hyperexcitability [ 5 , 6 ]. Moreover, brain invasion has been shown to be associated with preoperative seizures, leading to a disruption of the pial-glial basement membrane, potentially inducing astrocytic responses and altering the tumor microenvironment similar to primarily intra-axial malignancies [ 5 ]. In our study cohort, brain invasion was not directly associated with preoperative seizures.…”
Section: Discussionmentioning
confidence: 99%
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“…Patients with meningioma who experience seizures have a significantly worse progression-free survival rate compared with those who do not experience seizures, suggesting that meningiomaassociated epilepsy signals the presence of a more aggressive tumor. 1,2 Seizures in meningiomas occur in approximately 30% of patients.…”
Section: Introductionmentioning
confidence: 99%
“…However, the incidence of post-operative seizures still ranges between 26%-60% in the literature, which includes patients who are not seizure-free, as well as those who are seizure naïve and then experience post-operative seizures. 1,2 In this article, we would like to discuss about the predictors of seizure/epilepsy in postoperative patients. located in the motor cortex of the frontal lobe.…”
Section: Introductionmentioning
confidence: 99%