The clinical and histopathological aspect of the liver, lung, and kidney in Malaria

Akil, Syafarinah Nur Hidayah

doi:10.30651/jqm.v3i2.2833

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…These results indicated that the EECS was effective in reducing plasma levels of SGOT and SGPT to the normal levels. The excessive hepatic enzymes were released by the injured hepatocytes due to malarial infection [ 53 ]. In this study, the necrosis and degraded cells in the liver were repaired by the administration of EECS followed by the reduction in plasma level of SGOT and SGPT.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice

Ekasari

Mahardiani

Putri

et al. 2022

Veterinary Medicine International

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Currently, the presence of antimalarial drug resistance has become a major obstacle in the treatment of malaria. To overcome the problem, a series of studies are needed to find new antimalarial drugs from plants. Previously, 90% ethanolic extract of Cassia spectabilis DC (EECS) leaves have been reported to have antimalarial activity in vitro against Plasmodium falciparum and in vivo against Plasmodium berghei ANKA. The research is conducted to find out the toxicity and protective effects of EECS on the liver and kidneys of mice infected with P. berghei ANKA. The acute and subacute toxicity tests were carried out on healthy mice that were given EECS at a dose of 150 mg/kg BW. An antimalarial activity test was carried out at doses of 150 and 200 mg/kg BW in P. berghei-infected mice. Regarding hepatomegaly, further plasma levels of hepatic enzyme were analyzed, as well as histopathological observation of the liver to determine the effect of the extract on liver. The kidney was observed histopathologically as well. The acute toxicity test of EECS showed that there was no mouse died at the highest dose, indicating safe for the mice. The subacute toxicity based on the histology data showed no significant difference in the liver and kidney of mice between the tested group and the healthy group. The histological and enzymatic effect of EECS in mice infected with P. berghei showed the histological and enzymatic effect that improved liver function and the histopathological effect on kidneys with the highest activity at a dose of 200 mg/kg BW compared with the negative control. The results showed the EECS was not toxic in mice and repaired the liver and kidney functions of P. berghei ANKA-infected mice, indicating a good candidate for antimalarial drug development.

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Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice

Ekasari

Mahardiani

Putri

et al. 2022

Veterinary Medicine International

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“…1 Malaria causes organ dysfunction such as liver, lung, and brain. 2 One of the dangerous sign of malaria is anaemia, hypoglycaemia detected from the blood test. 3,4 These conditions impact cognitive impairment in children and productivity in adults.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic effects of Kaempferia Galanga against Plasmodium berghei: in vivo study

Lusiyana

2022

J. Teknol. Laboratorium

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Recently, medicinal plants have been the main source in treating malaria. Kaempferia galanga was investigated as an antioxidant, and anti-inflammation. In vivo study of K. galanga had been verified as antimalarial for severe malaria. The objective of this study is to investigate the chemoprophylactic effect, body composition, and blood parameters of K. galanga against Plasmodium berghei. The prophylactic effects were determined by employing K. galanga (50; 100 and 200 mg/kg) in mice infected with P. berghei. Mice were subdivided into 4 groups (control negative and 3 treatment groups). The treatment groups received K. galanga daily for 3 days before the inoculation of P. berghei. Each mice were inoculated with the infected blood containing 106 of P. berghei. Parasitemia and body weight were calculated every day until 5 days post-inoculation, and the blood parameters was monitored in day 5. The parasitemia on the fifth days after inoculation revealed a significant suppresses effect compared to control (p<0.05). The suppressed effect by doses 50 mg/kg; 100 mg/kg; 200 mg/kg and negative control were 0.83%; 1.96%; 2.82%, and 17.8% respectively. The body weight on treatment groups was normal, but the control group decreased (p<0.05). The blood parameters on treatment groups were normal compared to control group. The K. galanga possess the prophylactic effect, normal weight and blood parameters against Plasmodium berghei.

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“…Impaired kidney function is characterized by increased levels of blood urea nitrogen (BUN) and creatinine ((Isa et al, 2013;Kalia et al, 2015). Kidney histology research in malaria shows acute tubular necrosis, glomerulonephritis, and interstitial nephritis (Akil, 2019;Koopmans et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of virgin coconut oil in Plasmodium berghei ANKA infected Balb/c mice

Akil

Arwati²,

Wardhani³

et al. 2021

Qanun Medika

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Malaria is a parasitic infectious disease caused by Plasmodium, which remains a world health problem with an estimated 219 million cases worldwide. In severe malaria infection, several organs of the body can be affected, including the kidneys. One of the pathophysiology associated with the worsening of this disease is oxidative stress. The use of antioxidants is expected to prevent this, and one product that has a high antioxidant content is virgin coconut oil (VCO). This study aimed to analyze the effect of VCO on the kidney in Plasmodium berghei ANKA-infected mice. This study was an in vivo laboratory experimental study with a randomized post-test only control group design using 35 BALB/c mice infected with P. berghei ANKA, weighing 20-30 grams. VCO with the Javara® brand is used with doses of 1, 5, and 10 ml/kg body weight (kgBW)/ day. The parameter assessed were levels of BUN, creatinine, and renal histopathological changes. The administration of VCO on the treated group shows minimal tubular necrosis and glomerulonephritis compared to the negative control group. The BUN and creatinine levels in the treated group were also lower than the negative control group. The results showed that VCO has a nephroprotective effect against P. berghei ANKA infection in mice.Keywords: malaria, kidney, virgin coconut oil

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The clinical and histopathological aspect of the liver, lung, and kidney in Malaria

Cited by 3 publications

References 10 publications

Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice

Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice

Prophylactic effects of Kaempferia Galanga against Plasmodium berghei: in vivo study

Nephroprotective effect of virgin coconut oil in Plasmodium berghei ANKA infected Balb/c mice

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