The clinical application of 18F-FDG PET/CT in pancreatic cancer: a narrative review

Pu, Yongzhu; Wang, Chun; Zhao, Sheng; Xie, Ran; Zhao, Lei; Li, Kun; Yang, Chungang; Zhang, Rui; Tian, Yadong; Tan, Lixian; Li, Jindan; Li, Shujuan; Chen, Long; Sun, Haitao

doi:10.21037/tcr-21-169

Cited by 12 publications

(9 citation statements)

References 102 publications

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“…MR only shows good diagnostic performance in hepatic recurrence of pancreatic cancer [ 14 ]. PET/CT has broadly been utilized in pancreatic cancer management as a new device to help diagnose the location of cancer through the metabolism of tumor cells [ 26 – 28 ]. Furthermore, the relevance of PET/CT in the recurrence of pancreatic cancer has long been researched and established [ 25 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis

Shan

Huo

et al. 2022

Applied Bionics and Biomechanics

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Purpose. The CT scan is the best common screening test for pancreatic cancer recurrence after surgery. The goal of our meta-analysis was to assess the diagnostic accuracy of 18F-FDG PET/CT for pancreatic cancer recurrence. Methods. We examined PubMed and Embase for suitable papers between 2009 and 2022. The researchers considered studies that looked at the diagnostic usefulness of 18F-FDG PET/CT in identifying local and/or distant disease recurrence throughout the follow-up following pancreatic cancer resection. The Quality Assessment of Diagnostic Performance Studies-2 (QUADAS-2) method was used to evaluate the quality of each study. For each of the publications included, two researchers extracted data independently. The extracted data included general data (authors, year of publication), literature characteristics (country, type of literature, and design of study), characteristics of the patient (patients’ number, mean or median age, and treatment regimen), and technical aspects (scanner, injection activity, and image analysis). Results. The analysis includes 7 trials with a total of 263 patients. The sensitivity and specificity of 18F-FDG PET/CT in detecting recurrent pancreatic cancer following definitive treatment were 0.89 (95 percent CI: 0.83-0.93) and 0.88 (95 percent CI: 0.72-0.96), respectively, according to the pooled estimates. PET/CT performed well in the diagnosis of recurrent pancreatic cancer, with an AUC of 0.94. (0.91-0.95). Conclusions. 18F-FDG PET-CT was found to be a reliable detection method in recurrent pancreatic tumor.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis

Shan

Huo

et al. 2022

Applied Bionics and Biomechanics

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“…The usefulness of FDG-PET/CT as a prognostic indicator has thus far been controversial (13)(14)(15)(16). Various FDG-PET/CT-based volumetric imaging parameters, such as metabolic tumor volume and total lesion glycolysis, have been suggested as prognostic indicators for pancreatic cancer (17)(18)(19).…”

Section: Univariate Multivariatementioning

confidence: 99%

Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study

Kobayashi,

Einama,

Tsunenari

et al. 2024

Oncol Lett

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Tumor resectability, which is increasingly determined based on preoperative chemotherapy, is critical in determining the best treatment for pancreatic cancers. The present study evaluated the usefulness of serum carbohydrate antigen 19-9 (CA19-9) and the preoperative 8F-fluorodeoxyglucose positron emission tomography/computed tomography standardized uptake value (SUV) percentage change (SUVmax%=[(SUVmax2-SUVmax1)/SUVmax1] ×100, where SUVmax1 and SUVmax2 represent the initial and delayed phases, respectively) as biological factors indicative of tumor resectability. The present study included patients with resectable pancreatic cancer who underwent complete surgical resection, for whom both CA19-9 and SUVmax% were documented using cut-off values of 500 U/ml and 24.25%, respectively. Patients were classified as follows: i) High CA19-9 and SUVmax%: both CA19-9 and SUVmax% were elevated; ii) high CA19-9 or SUVmax%: either CA19-9 or SUVmax% were elevated; or iii) low CA19-9 and SUVmax%: neither value met the cut-off. Relapse-free survival (RFS) and overall survival (OS) were calculated, for which univariate and multivariate analyses were performed. Of the 86 patients included, 39 were classified as high CA19-9 or SUVmax% and 12 as high CA19-9 and SUVmax%, with the former group having a significantly worse RFS (vs. low CA19-9 and SUVmax%; P<0.001; vs. high CA19-9 or SUVmax%; P=0.011) and OS (vs. low CA19-9 and SUVmax%, P=0.002; vs. high CA19-9 or SUVmax%, P<0.001). Therefore, high CA19-9 and SUVmax% was an independent predictor of worse RFS (P<0.001) and OS (P=0.003). In conclusion, CA19-9 and SUVmax% can be utilized as biological indicators of resectability.

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“…At present, the diagnostics based on positron-emission tomography is widely applied in inflammatory diseases of bones, joints, heart, sarcoidosis, diabetic foot, query fevers, oncological diseases of varied localization, metastases, when planning radiation therapy. As a rule, the enhancement by gadolinium or fluorinedeoxyglucose is used (Casali et al,, 2021;Chen, Chen, Wang, 2022;Kocher, Ruge, Galldiks, Lohmann, 2020;Kratochwil et al, 2019;Pu et al, 2021;Rischpler et al,, 2019;Yang et al, 2022).…”

Section: Positron Emission Tomography (Pet) Scintigraphymentioning

confidence: 99%

Benefits of Modern Imaging Techniques in Medicine

Bogomolov,

Antonov,

Ilin

et al. 2024

RDLUZ

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Relevance. For more than 100 years, medical practice has used imaging methods to observe pathological changes localized in the human body. The first method was radiography, which became popular among doctors, but later it turned out that high radiation exposure increases the incidence of tumor diseases, which is why standards for permissible radiation doses were developed for patients and radiologists. The introduction of radiocontrast agents also had contraindications that should be taken into account. Ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and angiography methods have significantly increased the diagnostic capabilities of instrumental methods. The purpose of this review is to analyze the advantages and disadvantages of modern imaging methods in medicine. Methods. To achieve the purpose of the review, a literature search was conducted in Google Scholar and PubMed databases. Results. 1) The main indication for the X-ray method is visualization of bone structures. 2) X-ray contrast methods are optimal for studying hollow organs and blood vessels. 3) The advantage of MRI is the ability to visualize soft tissue well. 4) CT helps to reconstruct the spatial architecture of organs. 5) Ultrasound allows you to observe the condition of the embryo and fetus, as well as internal organs.

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The clinical application of 18F-FDG PET/CT in pancreatic cancer: a narrative review

Cited by 12 publications

References 102 publications

The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis

The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis

Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study

Benefits of Modern Imaging Techniques in Medicine

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