The clinical behavior of inverting papilloma of the nose and paranasal sinuses: Report of 112 cases and review of the literature

Phillips, P. Perry; Gustafson, Ray O.; Facer, George W.

doi:10.1288/00005537-199005000-00004

Cited by 197 publications

(155 citation statements)

References 12 publications

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“…As other authors have repeatedly shown, 1,5,7,12,13 our series indicates that aggressive surgical procedure can reduce the recurrence rate of inverted papilloma. Our conservative-treatment group showed a somewhat higher recurrence rate (33.9 per cent) when compared with other reported conservative-treatment groups (around 18 per cent).…”

Section: Discussionsupporting

confidence: 73%

“…Because of its high recurrence rate and aggressive nature, management of inverted papilloma has changed from conservative intranasal piecemeal excision to a more aggressive wide excision by lateral rhinotomy combined with a medial maxillectomy. [4][5][6][7][8] However, some authors have reported recently that an endoscopic endonasal approach can be performed in selected cases in which tumour extension is limited. [9][10][11] Few reports have been published on the relationship between polyp and inverted papilloma, and on the treatment outcome of recurrent inverted papilloma.…”

Section: Introductionmentioning

confidence: 99%

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Treatment outcomes of primary and recurrent inverted papilloma: an analysis of 96 cases

Yoon

Kim²,

Choi³

2002

J. Laryngol. Otol.

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This series was undertaken to investigate the incidence of associated polyps and the recurrence rates of inverted papillomas with, or without, malignancies, as well as the treatment outcomes of the recurred cases.A retrospective study evaluating the pathology, associated polyps, types of operation, recurrence rate after original operation, and surgical outcomes of recurred cases was conducted upon 96 patients diagnosed with inverted papilloma.The overall malignancy rate was 11.5 per cent with synchronous tumours accounting for 9.4 per cent and metachronous for 2.1 per cent. In ammatory polyps were found in association with inverted papilloma in 21.9 per cent. In cases without malignancies, the recurrence rate after the original conservative procedure was 33.9 per cent, compared to 14.3 per cent after a medial maxillectomy. In cases with malignancies, the recurrence rate after the original surgical procedure was 22.2 per cent.Our study indicates that more aggressive and bolder surgical resection of inverted papilloma should be undertaken as a primary treatment method, or as a treatment for recurrent cases to reduce the recurrence rate of inverted papilloma with, or without, malignancy.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Treatment outcomes of primary and recurrent inverted papilloma: an analysis of 96 cases

Yoon

Kim²,

Choi³

2002

J. Laryngol. Otol.

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“…Ki-67 has been utilized to demonstrate proliferating cells in G1, S, G2 and M phases of the cell cycle [15]. Ki-67 has been used to study the growth fraction and cytokinetic activity in various carcinomas [15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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“…Rare locations include the sphenoid sinus and frontal sinus [1][2][3][4][5]9 . In our study, the most frequent location and extension of IP was represented by involvement of both ethmoid and maxillary sinuses, in 110 cases from our series (67.90%), concurring with most authors.…”

Section: Discussionmentioning

confidence: 99%

“…This being said, tumors developing in the maxillary sinus will have to grow and extend to different close regions before expressing any discomfort to the patient, thus delaying the diagnosis. Common symptoms of IP are progressive unilateral nasal obstruction, blood mixed nasal discharge, headache, frequent throat clearing, sometimes epiphora or symptoms of sinusitis 4,5,16 . Clinical and paraclinical assessment of IP includes nasal endoscopy with anatomic macroscopic description of the tumor, imaging studies and also biopsy.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic approach of sinonasal inverted papilloma – our 15 years’ experience on 162 cases

Budu¹,

Schnaider²,

Bulescu

2015

Romanian Journal of Rhinology

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BACKGROUND. Inverted papilloma is a benign tumor of the nose and sinuses, with a high risk of recurrence and malignant degeneration. The inverted papilloma is a slow growing tumor that can be approached through an endoscopic or external approach, depending on its stage.OBJECTIVE. The aims of the study are to identify the particularities of diagnosis of the inverted papilloma, to establish the correct steps in surgical treatment of this tumor and to open the access for other steps of treatment.MATERIAL AND METHODS. The authors present their experience in managing the sinonasal inverted papilloma in a 15-year retrospective clinical study, which included 162 patients. The preoperative protocol consisted in clinical examination, nasal endoscopy, radiologic imaging (CT scan) and biopsy with histopathology results and immunohistochemistry findings. Surgical removal of the inverted papilloma was performed by endoscopic techniques, according to the stage of the tumor. We were interested in the recurrence rate of the tumor and its malignancy after a long-term follow-up.RESULTS. In our series, we included 162 patients and we had 26 (16.04%) recurrences and 12 (7.40%) malignant degenerations. All our patients were diagnosed in Krouse stages I, II and III and underwent endoscopic resection of the tumor.CONCLUSION. In order not to have any leftover tumor (the most important factor of recurrence and malignant transformation), it is mandatory to have a complete diagnosis of the inverted papilloma, a precise surgical technique and a rigorous followup. In some cases, the surgical treatment is associated with other type of treatment (antiviral, antiangiogenetic).

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The clinical behavior of inverting papilloma of the nose and paranasal sinuses: Report of 112 cases and review of the literature

Cited by 197 publications

References 12 publications

Treatment outcomes of primary and recurrent inverted papilloma: an analysis of 96 cases

Treatment outcomes of primary and recurrent inverted papilloma: an analysis of 96 cases

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Endoscopic approach of sinonasal inverted papilloma – our 15 years’ experience on 162 cases

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