This article presents a clinical observation of successful treatment of a patient with multiple cylindroma of the scalp and trunk using photodynamic therapy (PDT) after radiotherapy. The first masses were found in 2008, at the same time they were surgically removed. There has been a progression of the process since 2019 -multiple masses on the scalp and trunk. There was another visit to doctors. After verification of diagnosis radiation therapy was received. However, soon after the treatment, the appearance of new and growth of existing foci has been noted. A multistage PDT with good clinical and cosmetic effect was carried out at Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan.