The Clinical Characteristics of Pediatric Non-Infectious Uveitis in Two Tertiary Referral Centers in Turkey

Yalçındağ, F Nilüfer; Güngör, Sirel Gür; Değirmenci, Mehmet Fatih Kağan; Sezenöz, Almila Sarıgül; Özçakar, Z. Bı̇rsı̇n; Baskın, Esra; Yalçınkaya, Fatma Fatoş; Atilla, Hüban

doi:10.1080/09273948.2019.1674890

Cited by 23 publications

(15 citation statements)

References 28 publications

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“…Intermediate uveitis was reported to be the most frequent form (34.2%) in another study from Turkey but was not detected in any patients in a Japanese study, while non-infectious intermediate uveitis was observed at rates of 25.6% and 19.9% in studies conducted in Brazil and the USA, respectively. 4,11,12,13 Posterior uveitis (4.3%) and panuveitis (10.9%) were less common in our study.…”

Section: Discussioncontrasting

confidence: 52%

“…4,11,12 Similarly, a recent publication from Turkey reported this ratio to be 1:1.1 in non-infectious pediatric uveitis. 13 In a review of pediatric uveitis, Tugal-Tutkun 3 stated that uveitis series from North America and Europe showed rates of 35-50% for anterior uveitis, 10-20% for intermediate uveitis, 15-25% for posterior uveitis, and 10-20% for panuveitis. The prevalence of anterior uveitis has been reported to be 46-62% in recent publications.…”

Section: Discussionmentioning

confidence: 99%

“…Anterior uveitis was present in 100% of patients with JIA and TINU and 75% of patients with sarcoidosis, whereas In this series, which had a final visual acuity of 0.15±0.30 LogMAR, the prevalence of legal blindness (3/60 or worse) was determined to be 1.21%. In pediatric uveitis studies conducted in Turkey, Yüce et al 16 reported a visual acuity of 20/200 or worse in 4 eyes and 20/40 or worse in 18 of 64 eyes with pediatric uveitis, and Yalçındağ et al 13 reported a visual acuity of 20/200 or worse in 8 eyes and between 20/200 and 20/40 in 16 eyes. Recent studies have indicated that the rate of legal blindness among uveitis patients has decreased from 19-69.6% to 7.7-9.7%.…”

Section: Discussionmentioning

confidence: 99%

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Follow-up Findings of Non-infectious Pediatric Uveitis Patients

Tekin¹,

Yener²,

Akbulut³

et al. 2021

tjo

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Objectives: In this study, we aimed to describe the demographic and clinical findings of children with uveitis at a tertiary pediatric rheumatology and ophthalmology center. Materials and Methods:A retrospective cross-sectional study was conducted with 46 patients who were diagnosed with uveitis before the age of 16 years and were followed regularly for at least 6 months between January 2013 and June 2019. Demographic data, uveitis characteristics, underlying diseases, systemic treatment modalities, drug side effects, complications, and surgical intervention were evaluated. Results: Eighty-three eyes of 46 patients were included in the study. The mean age at diagnosis of uveitis was 9.2±4.5 (1.6-15.6) years, and the mean uveitis follow-up period was 54±41 (6-191) months. Twenty-one patients (45.7%) had uveitis associated with rheumatologic diseases. Juvenile idiopathic arthritis was the most common disease (23.9%). Visual acuity was categorized as moderately impaired in 6 eyes (7.2%), severely impaired in 4 eyes (4.8%), and blindness in 1 eye (1.2%). Methotrexate (87%) was the most frequently used systemic immunosuppressive agent in treatment. Adalimumab (73.9%) was added to treatment in resistant cases. Thirtyfive patients (76.1%) had complications in at least 1 eye secondary to uveitis or uveitis treatment. Posterior synechiae (11 eyes, 13.2%) was the most common complication during treatment. Conclusion:In order to preserve visual acuity, pediatric uveitis should be recognized early and especially persistent/chronic cases should be started on effective systemic treatment immediately.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Follow-up Findings of Non-infectious Pediatric Uveitis Patients

Tekin¹,

Yener²,

Akbulut³

et al. 2021

tjo

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“…Ocular in ammation was bilateral in four of the cases and all OIDs had recurrent and chronic courses. Moreover, one of the patients with uveitis had bilateral panuveitis that is an infrequent type of pediatric uveitis [25]. In two of the patients, typical FMF attacks and recurrences of OIDs were temporally associated.…”

Section: Discussionmentioning

confidence: 95%

Ocular inflammatory diseases in children with familial Mediterranean fever: a true association or a coincidence?

Avar-Aydın

Aydın

Özçakar

et al. 2021

Preprint

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Purpose: To describe the characteristics of patients with familial Mediterranean fever (FMF) concurrent with ocular inflammatory disease (OID) and to criticize possible relations between them.Methods: Clinical data were extracted from electronic medical records. Additionally, the medical literature on OIDs in FMF was reviewed.Results: Among 512 pediatric patients with FMF, five patients were found to have OIDs: bilateral chronic uveitis, recurrent orbital myositis (ROM), recurrent optic neuritis, and acquired Brown’s syndrome. The first cases of ROM and acquired Brown’s syndrome in FMF have been introduced in the literature. All patients presented with early-onset typical FMF attacks carried at least one M694V mutation and experienced OID while on colchicine. Conclusion: Increased frequency of OIDs in FMF as per the pediatric population and relapsing and chronic course of OIDs occasionally with concurrent FMF attacks suggest that this inflammatory syndrome especially those carrying M694V mutations may be a predisposing factor for OIDs.

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“…Pediatric uveitis (PU), which accounts for 5-10% of all uveitis [1], is a topic of particular concern to uveitic specialists due to its unpredictability and intractability. PU is a group of heterogenous disease entities with epidemiology, etiology and clinical patterns vary among studies from different areas worldwide, and anterior uveitis is the most frequent ophthalmic manifestation of the PU [2][3][4][5][6][7]. The pathogenesis of PU remains incompletely understood and PU is more likely to be asymptomatic than uvetis in adults.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis

Xiao¹,

Qu²,

Zhao³

et al. 2021

Preprint

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Purpose: Using spectral domain optical coherence tomography angiography (SD-OCTA) to evaluate tomographic and microvascular parameters in the macula in quiescent unilateral anterior pediatric uveitis (APU) patients.Methods: Forty-two eyes of 21 patients diagnosed with unilateral APU and 21 eyes of 21 normal controls (NC) were included in this study. 6*6 mm macular scanning mode of SD-OCTA was used for all subjects. The central macular thickness (CMT), subfoveal choroidal thickness (SFCT), vascular density (VD) of superficial capillary plexus (SCP) and the deep capillary plexus (DCP), the foveal avascular zone (FAZ) area, and choriocapillary flow density (CFD) were analyzed and compared among affected, fellow, and NC eyes. Correlation analysis were used to evaluate the potential correlating factors with CFD.Results: DCP VD and CFD were significantly lower in quiescent affected eyes as compared to fellow and NCs eyes (DCP VD both p<0.001; CDF1.0: p=0.012 and p=0.003; CDF1.5: p=0.015 and p=0.006; CDF3.0: p=0.036 and p=0.010, respectively). SCP VD, DCP VD and CMT were significantly lower in the fellow eyes as compared to NC eyes (p=0.021; p<0.001; p=0.037, respectively); CFD was negatively correlated with FAZ and CMT in affected eyes and fellow eyes. No significant differences were detected in FAZ among the 3 groups (p > .05).Conclusions: As compared to NC eyes, both retinal and choroidal microvasculature were impaired in eyes with quiescent APU; retinal microvasculature in unaffected fellow eyes of unilateral APU was also impaired. OCTA is a useful technology for detection of subclinical microvascular changes in APU and may be useful as an additional prognostic tool.

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The Clinical Characteristics of Pediatric Non-Infectious Uveitis in Two Tertiary Referral Centers in Turkey

Cited by 23 publications

References 28 publications

Follow-up Findings of Non-infectious Pediatric Uveitis Patients

Follow-up Findings of Non-infectious Pediatric Uveitis Patients

Ocular inflammatory diseases in children with familial Mediterranean fever: a true association or a coincidence?

Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis

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