The clinical characteristics of posterior reversible encephalopathy syndrome in patients with chronic renal failure

Hu, Hongtao; Xu, Shen; Hu, Shuang; Xu, Weiqiang; Shui, Hua

doi:10.3892/etm.2017.4570

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…CRF is a severe renal damage with a serious clinical symptom resulting from multiple predisposing factors, such as diabetes glomerulonephritis, and hypertension [2]. CRF is considered as one of the most significant public health problems, with accumulating rates of occurrence and development [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of Long Non-Coding RNA LINC00963 on Renal Interstitial Fibrosis and Oxidative Stress of Rats with Chronic Renal Failure via the Foxo Signaling Pathway

Chen

Zhang

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Chronic renal failure (CRF) is usually associated with chronic diseases such as congestive heart failure and diabetes mellitus, the prevalence of which is increased with age. This study is designed to investigate the role of long intergenic non-coding RNA (lincRNA) LINC00963 in renal interstitial fibrosis (RIF) and oxidative stress (OS) of CRF via the forkhead box O (FoxO) signaling pathway. Methods: Microarray data and annotated probe files related to CRF were downloaded by retrieving Gene Expression Omnibus (GEO) database to screen differentially expressed lncRNA. Multi Experiment Matrix (MEM) website and dual-luciferase reporter gene assay were used to predict and verify the target gene of LINC00963, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to identify the major signaling pathways involved. A total of 60 Wistar male rats were randomly selected and divided into the sham (n = 10) and model (n = 50) groups. Five rats in the sham group and thirty rats in the model group were sub-categorized into the control, blank, negative control (NC), LINC00963 vector, si-LINC00963, si-FoxO3, and si-LINC00963 + si-FoxO3 groups (n = 5). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were performed to evaluate the expressions of LINC00963, FoxO3a, TGF-β1, FN, GSH-PX, Bax, and Bcl-2. Measurement of changes in OS indexes including BUN, MDA, GSH-Px, SOD, and Na⁺-K⁺-ATP were conducted. Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of inflammatory factors including TNF-α, IL-6, ICAM-1 and FN. TUNEL staining was performed to evaluate cell apoptosis. Results: LINC00963 was highly expressed in CRF rats and FoxO3 was predicted and then verified as a target gene of LINC00963. FoxO3 gene participated in the FOXO signaling pathway. Compared with the blank and NC groups, there were significantly decreased expressions of LINC00963, TGF-β1, FN, and Bax in the si-LINC00963 group, while increased expressions of GSH-PX, FoxO3a, and Bcl-2. The vitality values of BUN and MDA in the si-LINC00963 group declined, while enzymatic activities of GSH-Px, SOD and Na⁺-K⁺-ATP elevated in comparison to the blank and NC groups. The levels of TNF-α, IL-6, ICAM-1 and FN, and cell apoptosis rate in the si-LINC00963 group decreased in comparison to the blank and NC groups. All the results in the si-LINC00963 group were opposite in the LINC00963 vector and si-FoxO3 groups. Conclusion: Taken together, we conclude that down-regulation of LINC00963 suppresses RIF and OS of CRF by activating the FoxO signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Effects of Long Non-Coding RNA LINC00963 on Renal Interstitial Fibrosis and Oxidative Stress of Rats with Chronic Renal Failure via the Foxo Signaling Pathway

Chen

Zhang

Zhou

et al. 2018

Cell Physiol Biochem

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“…2 Usually, PRES is identified based on characteristic clinical symptoms, neuroimaging (computed tomography or images of MRI). 10 MRI is the gold standard and only 50% of the lesions were revealed by the CT scan. 11 In order to identify symptoms of cytotoxic oedema, which is a symptom of the progression of the disease, PRES clinicians should be aware of MRI findings in a suspected case.…”

Section: Discussionmentioning

confidence: 99%

Posterior reversible encephalopathy syndrome (PRES) presenting as Status Epilepticus in a case of Autoimmune Hemolytic Anemia (AIHA): A Case report

et al. 2021

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Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state, caused by imbalance in autoregulation of posterior cerebral circulation. We report a case of young female, presented at emergency department with complains of nausea, vomiting and generalized tonic clonic seizures prior to admission. During the course of hospital stay patient landed in status epilepticus which was treated appropriately. Patient’s magnetic resonance imaging (MRI) was done which had classical features of vasogenic edema in occipital and parietal region, suggestive of PRES. She was a known case of autoimmune hemolytic anemia thatwas treated with multiple blood transfusions and low dose oral steroids. She was discharged after complete resolution of symptoms with the advice to follow up in medicine outpatient department. Our case describes about autoimmune hemolytic anemia in which occurrence of PRES is uncommon. Early diagnosis and robust treatment can prevent permanent damage to the brain, and is often associated with complete recovery.

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“…Interestingly, similar brain regions are affected in patients with kidney failure and cerebral malaria. Indeed, both diseases have been associated with PRES imaging features with predominant brain swelling in the parieto-occipital lobes [ 34 , 69 ], although there is a stronger cytotoxic edema component in cerebral malaria patients compared to AKI and CKD patients with kidney failure [ 70 ]. In addition, subcortical microhemorrhages are frequent in both CKD and cerebral malaria [ 63 , 71 ], a feature that extends to the basal ganglia, corpus callosum, and cerebellum in the latter [ 71 ].…”

Section: Neuroimaging Identifies Common Susceptible Brain Areas In Ce...mentioning

confidence: 99%

The kidney–brain pathogenic axis in severe falciparum malaria

Conroy

Datta

Hoffmann

et al. 2023

Trends in Parasitology

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The clinical characteristics of posterior reversible encephalopathy syndrome in patients with chronic renal failure

Cited by 7 publications

References 33 publications

Effects of Long Non-Coding RNA LINC00963 on Renal Interstitial Fibrosis and Oxidative Stress of Rats with Chronic Renal Failure via the Foxo Signaling Pathway

Effects of Long Non-Coding RNA LINC00963 on Renal Interstitial Fibrosis and Oxidative Stress of Rats with Chronic Renal Failure via the Foxo Signaling Pathway

Posterior reversible encephalopathy syndrome (PRES) presenting as Status Epilepticus in a case of Autoimmune Hemolytic Anemia (AIHA): A Case report

The kidney–brain pathogenic axis in severe falciparum malaria

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