The clinical course of epidemic hemorrhagic fever

Sheedy, John A.; Froeb, Herman F.; Batson, Hugh A.; Conley, C.; Murphy, J. Paul; Hunter, Richard B.; Cugell, David W.; Giles, Robert B.; Bershadsky, Sol C.; Vester, John W.; Yoe, Robert H.

doi:10.1016/0002-9343(54)90268-5

Cited by 101 publications

(32 citation statements)

References 14 publications

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“…In addition, the severity of the ill ness (symptoms, physical signs and laboratory data) sug gests that HFRS in Greece like in other Balkan countries [11][12][13] resembles more closely the severe form of the dis ease caused by the Hantaan virus in Asia [9,14], Nevertheless, many patients in this series did not evolve through the five recognized phases of the disease [15], but all of them developed acute renal failure; 6 were supported by dialysis. However, not in all patients oligu ria or anuria were prominent features during hospitaliza tion.…”

Section: Discussionmentioning

confidence: 94%

Hemorrhagic Fever with Renal Syndrome in an Endemic Area of Greece

et al. 1992

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From 1983 to 1990, 32 patients with hemorrhagic fever with renal syndrome (HFRS) were admitted to our hospital. The diagnosis was confirmed by high IgM type titers of antibodies to Hantaan virus. All patients presented with serum and urine abnormalities suggesting renal involvement. Serum creatinine was elevated and ranged between 1.8 and 14.3 mg/dl. Proteinuria ranged between 0.5 and 6.4 g/24 h. Seven patients died due to shock or hemorrhage, while 6 patients were supported by hemodialysis or peritoneal dialysis. Five of them had a complete recovery. Two patients were discharged with some degree of renal impairment which remained stable 12-15 months later. Kidney biopsy in the first patient performed 1 year after his discharge revealed some degree of interstitial fibrosis and tubular atrophy as well as an area with ischemic and sclerosed glomeruli. We conclude that HFRS in Greece is a severe disease with a high mortality rate. The disease may cause chronic renal failure in a limited number of patients.

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Section: Discussionmentioning

confidence: 94%

Hemorrhagic Fever with Renal Syndrome in an Endemic Area of Greece

et al. 1992

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“…This severe form manifests clinically with the long recognised acute triad of fever, haemorrhage and renal failure [82]. The classical course of severe HFRS can be considered to have ®ve recognised phases: febrile, hypotensive, oliguric, diuretic and convalescent [83,84].…”

Section: Hfrs Caused By Hantaan (Htn) and Dobrova (Dob) Virus Infectionmentioning

confidence: 99%

Hantaviruses

McCAUGHEY¹,

Hart

2000

Journal of Medical Microbiology

111

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“…Hantavirus pulmonary syndrome (HPS) occurs in the Americas (4) (5) , while hemorrhagic fever with renal syndrome (HFRS) occurs in Europe and Asia (2) (3) (6) , with occasional reports of cross occurrence (7) .…”

Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus diseases are emerging human diseases caused by Hantavirus spp. of the Bunnyaviridae family. Hantavirus pulmonary syndrome (HPS) has been detected in the Federal District (DF) of Brazil since 2004. Among the 27 Brazilian Federal Units, DF has the highest fatality rate. More than 10 years have already passed since then, with confi rmation of cases caused by the Araraquara and Paranoa species. The reservoir is Necromys lasiurus. Methods: Local surveillance data of the confi rmed cases were analyzed, including age, sex, month and year of occurrence, clinical symptoms, syndromes and outcomes, and probable transmission place (PTP). The cases were mainly confi rmed by IgM detection with a capture enzyme immunoassay. The cases were classifi ed as autochthonous if PTPs were in the DF area. Results: From 2004 to 2013, in the DF, 126 cases of hantavirus were confi rmed, and the cumulative incidence was 5.0 per 100,000 inhabitants. The occurrence of cases was predominantly from April to August. At least 75% of the cases were autochthonous. Acute respiratory failure was reported in 47.5% of cases, and the fatality rate was 40%. Conclusions: In the DF, the cumulative incidence of HPS was one of the highest worldwide. A seasonal pattern of hantavirus disease in the dry season is clear. There was a high frequency of severe clinical signals and symptoms as well as a high fatality rate. For the near future, visitors and inhabitants of DF rural areas, particularly male adults, should receive continuous education about hantavirus transmission and prevention.

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The clinical course of epidemic hemorrhagic fever

Cited by 101 publications

References 14 publications

Hemorrhagic Fever with Renal Syndrome in an Endemic Area of Greece

Hemorrhagic Fever with Renal Syndrome in an Endemic Area of Greece

Hantaviruses

Ten years of a hantavirus disease emergency in the Federal District, Brazil

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