2019
DOI: 10.1016/j.sjbs.2019.09.013
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The clinical effect of Prednisone in combination with Mycophenolate mofetil on idiopathic thrombocytopenic purpura (ITP) and its influence on the level of peripheral blood T lymphocytes and NK lymphocytes

Abstract: ObjectiveTo explore he curative effect and safety of Prednisone in combination with Mycophenolate in treating ITP and its influence on the level of peripheral blood T lymphocytes and NK lymphocytes.Method93 cases of ITP patients were divided into the observation group and the control group by the Random Number Table method, 48 cases for the observation group, 45 for another. Patients in the control group orally took 0.5 mg/kg Prednisone Acetate tablets daily, two times each in the morning and evening. And the … Show more

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Cited by 3 publications
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“…Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid which is an inhibitor of inosine-5-monophosphate dehydrogenase, which leads to l depletion of guanosine nucleotides in T and B lymphocytes, inhibition of proliferation, suppression of antibody production and cell-mediated immune response ( 125 ). In patients with ITP treatment with MMF was associated with changed in T cell lymphocytes, decreased inflammatory markers ( 126 ), decreased cytotoxic CD8+ T cells ( 127 ), suggesting that MMF works via T cell regulation. Among the case reports and case series, MMF is effective either as a single agent ( 128 130 ) or combined with other agents ( 131 ) in relapsed/refractory ITP.…”
Section: Treatment To Overcome Rituximab Resistancementioning
confidence: 99%
“…Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid which is an inhibitor of inosine-5-monophosphate dehydrogenase, which leads to l depletion of guanosine nucleotides in T and B lymphocytes, inhibition of proliferation, suppression of antibody production and cell-mediated immune response ( 125 ). In patients with ITP treatment with MMF was associated with changed in T cell lymphocytes, decreased inflammatory markers ( 126 ), decreased cytotoxic CD8+ T cells ( 127 ), suggesting that MMF works via T cell regulation. Among the case reports and case series, MMF is effective either as a single agent ( 128 130 ) or combined with other agents ( 131 ) in relapsed/refractory ITP.…”
Section: Treatment To Overcome Rituximab Resistancementioning
confidence: 99%