The clinical effect of topical phenytoin on wound healing: a systematic review

Shaw, Julia; Hughes, Ciara; Lagan, K.M.; Bell, P. M.

doi:10.1111/j.1365-2133.2007.08160.x

Cited by 72 publications

(67 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the mechanisms by which phenytoin heals human tissues are unclear, in vitro studies in laboratory animals and in human histopathology have contributed some information to the understanding of this phenomenon, by demonstrating stimulatory action of the drug on fibroblasts and collagen synthesis, cellular remodeling, inhibition of collagenase, and acceleration of autocrine and paracrine activity of growth factors through biochemical regulation of cell receptors involved (3)(4)8) and significant lymphocyte activation (20) . It is noteworthy that studies of moderate to strong evidence pointed to the analgesic effects of this drug for wounds (10) , and their authors mentioned the use of phenytoin as a secure application (10,12,15) , important factors when one is concerned about systemic absorption that application of topical phenytoin may trigger.…”

Section: Discussionmentioning

confidence: 99%

“…Overall, the studies were incomplete when describing how the phenytoin application was applied in the RCT, and the quality of methodological designs is still predominantly low, as was indicated in the pioneering work of Shaw and colleagues (3) .…”

Section: /Amentioning

confidence: 99%

“…The clinical effect of topical phenytoin on wound healing: a systematic review (3) The use topical phenytoin for healing of chronic venous ulcerations (9) 2011 Egypt RCT/ N104 divided into study group (N54) and control (N50) Manipulated lotion (1gr de phenytoin+ 25 mL lipossomal base) applied 1x/day for 8 weeks in venous ulcers…”

Section: Evidence /Recomendationmentioning

confidence: 99%

“…It acts by blocking neuronal excitation by binding to sodium channels at rest, preventing them from becoming functional and generating excitatory action potentials (1) . The possibility of its use as a healing agent began to be investigated by primary experimental studies in the field of dentistry, when, in 1939, hypergranulation of gingival tissue was recognized as its adverse effect, which suggested possible use of this drug as a healing agent in wounds (2)(3) .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

View full text Add to dashboard Cite

RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: /Amentioning

confidence: 99%

Section: Evidence /Recomendationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

View full text Add to dashboard Cite

show abstract

“…Only one of the trials was blinded and all were small and of short duration. 48 There is insufficient evidence on which to base a recommendation for topical phenytoin.…”

Section: Phenytoinmentioning

confidence: 99%

A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency

Orr¹,

Klement²,

McCrossin³

et al. 2017

OWM

View full text Add to dashboard Cite

++High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 -Meta-analyses, systematic reviews, or RCTs with a high risk of bias 2 ++ High quality systematic reviews of case control or cohort studies High quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal 2 + Well conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal 2 -Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal 3Non-analytic studies, eg case reports, case series NHS Quality Improvement Scotland (NHS QIS) is committed to equality and diversity and assesses all its publications for likely impact on the six equality groups defined by age, disability, gender, race, religion/belief and sexual orientation.SIGN guidelines are produced using a standard methodology that has been equality impact assessed to ensure that these equality aims are addressed in every guideline. This methodology is set out in the current version of SIGN 50, our guideline manual, which can be found at www.sign.ac.uk/guidelines/fulltext/50/index.html. The EQIA assessment of the manual can be seen at www.sign. ac.uk/pdf/sign50eqia.pdf. The full report in paper form and/or alternative format is available on request from the NHS QIS Equality and Diversity Officer.Every care is taken to ensure that this publication is correct in every detail at the time of publication. However, in the event of errors or omissions corrections will be published in the web version of this document, which is the definitive version at all times. This version can be found on our web site www.sign.ac.uk.This document is produced from elemental chlorine-free material and is sourced from sustainable forests.

show abstract