The clinical effectiveness and cost-effectiveness of bortezomib and thalidomide in combination regimens with an alkylating agent and a corticosteroid for the first-line treatment of multiple myeloma: a systematic review and economic evaluation.

Abstract

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Cost-Effectiveness of Autologous Stem Cell Treatment as Compared to Conventional Chemotherapy for Treatment of Multiple Myeloma in India

“…A patient with stage I disease will not necessarily proceed linearly through disease stages. Stage III disease can be reached without a requirement to pass through stage II first [16,17].…”

Early economic evaluation ot technologies for emerging interventions to personalize breast cancer treatment

“…This paper contributes to the literature on real-time applications of EVSI analysis to design and prioritize further research, which is under-represented [54][55][56][57][58]. Groot Koerkamp et al [55] 4 previously presented an EVSI application in a diagnostic procedure, but most EVSI analyses are applied to treatment interventions.…”

“…Yet it has to be proven, first, whether the ease of assaying outweighs the uncertainty on which lesion is being investigated, and second, whether the bloodstream ("liquid biopsies") can be used sufficiently reliable to forego tumor sampling [56,57]. Focusing outside of the tumor, host factors can affect the sensitivity of these, as they contribute significantly to varying drug responses.…”

“…For instance, fully implementing RG-NACT in the Netherlands, were 5701 MRI examinations were performed in 2013 (considering 843765 MRI examinations [14] performed in 148 MRIs), would only require 4.5 days of additional MRI scanning per year to current MRI utilisation (given our model assumptions). Furthermore, personnel technologists and radiologists is not expected to be a limiting implementation factor either, as availability is estimated to be of 1700 MRI technologists countrywide [53] and 10 breast radiologists per hospital [56].…”

“…Return on investment Profitability ratio that measures the effectiveness of an investment by measuring the amount of return of an investment relative to the investments' costs [112].…”