The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion

Zhang, Huachun; Jiang, Mengyuan; Gao, Lirong; Lin, Zhen

doi:10.1097/md.0000000000024758

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…In combination with the conventional cisplatin treatment of patients with malignant pleural effusion, Zhang et al (2021) employed the external application of mirabilite plus R. palmatum, the results showed the total effective rate of patients in the treatment group (66.67%) was significantly higher than that in the control group (54.76%). Zhang (2019) treated 90 patients with edema after hemorrhoid surgery with the ratio of R. palmatum and mirabilite mixed with 1:3 band and found that the effective rate and recovery rate were 93.09% and 27.58%, respectively.…”

Section: Clinical Applications Of Mirabilitementioning

confidence: 99%

The application of mirabilite in traditional Chinese medicine and its chemical constituents, processing methods, pharmacology, toxicology and clinical research

Tao,

Fu,

Wang

et al. 2024

Front. Pharmacol.

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Purpose: This study reviews the use of mirabilite in traditional Chinese medicine and various preparations by describing its chemical composition, processing methods, pharmacology, toxicology, and clinical research progress.Methods: The applications and processing methods of mirabilite are searched in traditional and modern Chinese medical writings, and the articles on chemical composition, pharmacological effects, toxicology, and clinical studies of mirabilite and its combinations in PubMed and China Knowledge Network are reviewed, sorted, and analyzed.Results: The main chemical component of mirabilite is sodium sulfate decahydrate (Na2SO4·10H2O), followed by small amounts of sodium chloride, magnesium sulfate, calcium sulfate, and other inorganic salts. This study systematically organizes the history of the medicinal use of mirabilite in China for more than 2,000 years. This mineral has been used by nine Chinese ethnic groups (Han, Dai, Kazakh, Manchu, Mongolian, Tujia, Wei, Yi, and Tibetan) in a large number of prescription preparations. The Pharmacopoeia of the People’s Republic of China (2020 edition) records stated that mirabilite can be used for abdominal distension, abdominal pain, constipation, intestinal carbuncle, external treatment of breast carbuncle, hemorrhoids, and other diseases. The traditional processing methods of mirabilite in China include refining, boiling, sautéing, filtration after hot water blistering, and firing. Since the Ming Dynasty, processing by radish has become the mainstream prepared method of mirabilite. Mirabilite can exhibit anti-inflammatory detumescence effects by inhibiting AMS, LPS, IL-6, IL-10, TNF-α, and NO levels and attenuating the upregulation of TNF-α and NF-κB genes. It can promote cell proliferation and wound healing by increasing the production of cytokines TGFβ1 and VEGF-A and gastrointestinal motility by increasing the release of vasoactive intestinal peptide, substance P, and motilin. It can increase the expression of low-density lipoprotein receptor and AKT phosphorylation in the liver by up-regulating bile acid synthesis genes; reduce TRB3 expression in the liver, FGF15 co-receptor KLB expression, and FGF15 production in the ileum, and JNK signal transduction; and increase the transcription of CYP7A1 to achieve a cholesterol-lowering effect. Mirabilite also has a variety of pharmacological effects, such as regulating intestinal flora, anti-muscle paralysis, anti-colon cancer, promoting water discharge, and analgesic. Only a few toxicological studies on mirabilite are available. External application of mirabilite can cause local skin to be flushed or itchy, and its oral administration is toxic to neuromuscular cells. The sulfur ions of its metabolites can also be toxic to the human body. At present, no pharmacokinetic study has been conducted on mirabilite as a single drug. This mineral has been widely used in the clinical treatment of inflammation, edema, wound healing, digestive system diseases, infusion extravasation, hemorrhoids, skin diseases, breast accumulation, muscle paralysis, intestinal preparation before microscopic examination, and other diseases and symptoms.Conclusion: Mirabilite has good application prospects in traditional Chinese medicine and ethnomedicine. In-depth research on its processing methods, active ingredients, quality control, pharmacokinetics, pharmacological and toxicological mechanisms, and standardized clinical application is needed. This paper provides a reference for the application and research of mirabilite in the future.

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Section: Clinical Applications Of Mirabilitementioning

confidence: 99%

The application of mirabilite in traditional Chinese medicine and its chemical constituents, processing methods, pharmacology, toxicology and clinical research

Tao,

Fu,

Wang

et al. 2024

Front. Pharmacol.

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“…Quyu Xiaozhong recipe (QYXZR) consists of rhubarb powder (30 g) and mirabilite (120 g), and they were confirmed to have broad anti-inflammatory and antioxidant properties. Modern pharmacological studies have shown that external applications of rhubarb and mirabilite is effective in relieving the symptoms of acute pancreatitis [7]. The above reports suggest that QYXZR has obvious anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 97%

Quyu Xiaozhong recipe exerts anti-inflammatory effect in acute mastitis by inhibiting TLR4/NF-κB signal pathway

Mingzheng¹,

Jin²

2023

Trop. J. Pharm Res

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Purpose: To investigate the effect of Quyu Xiaozhong recipe (QYXZR) on acute mastitis induced by Staphylococcus aureus in rats via TLR4/NF-κB signal pathway. Methods: The rat model of acute mastitis was constructed by injecting Staphylococcus aureus into the fourth pair of nipples of rats 5-7 days after parturition. The rats were treated with drugs 12 h after injection. Pathological changes in rat mammary tissue were determined using hematoxylin-eosin (H&E) staining. Myeloperoxidase (MPO) kit was used to evaluate MPO activity. Enzyme-linked immunosorbent assay (ELISA) was employed to determine the levels of inflammatory factors, while changes in protein expression of TLR4, NF-κB-p65, and IκB-α were determined by Western blot. Results: QYXZR intervention significantly attenuated pathological damage in rats and alleviated Staphylococcus aureus-induced mastitis. At the same time, QYXZR significantly reduced the expression of MPO and the levels of inflammatory factors (p < 0.05). Further molecular mechanistic studies revealed that QYXZR exerted anti-inflammatory effects by inhibiting TLR4/NF-κB signal pathway. Conclusion: QYXZR alleviates acute mastitis caused by Staphylococcus aureus via the inhibition of TLR4/NF-κB pathway, thus, providing the scientific and theoretical basis for the extensive use of this traditional Chinese medicine in the treatment of acute mastitis.

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Hyperthermic intrathoracic chemotherapy for the treatment of malignant pleural effusion caused by breast and ovarian cancer: A systematic literature review and pooled analysis

et al. 2022

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Breast and ovarian cancer account for over 30% of malignant pleural effusions (MPEs). Treatment of the metastatic disease requires control of the MPE. Even though primarily symptomatic, the treatment of the MPE can potentially affect the oncological course of the disease. The aim of this review is to analyze the effectiveness of intrathoracic chemotherapy in the treatment of MPE caused by breast and ovarian cancer. Methods: A systematic literature research was conducted up until May 2021. Studies published in English on patients undergoing either surgical or interventional intrapleural chemotherapy were included. Results: Thirteen studies with a total of 497 patients were included. Analysis was performed on 169 patients with MPE due to breast cancer and eight patients with MPE secondary to ovarian cancer. The pooled success rates of intrathoracic chemotherapy for controlling the MPE were 59.1% and 87.5%, respectively. A survival analysis was not possible with the available data. The overall toxicity of the treatment was low. Conclusions: Intrathoracic chemotherapy achieves symptomatic control of the MPE in 59.1% of patients with metastatic breast cancer and 87.5% of patients with metastatic ovarian cancer. This is inferior to other forms of surgical pleurodesis. Data from small case series and studies on intraperitoneal chemotherapy show promising results. However, formal oncological studies on the use of intrathoracic chemotherapy for metastatic breast or ovarian cancer are lacking. Further prospective pilot studies are needed to assess the therapeutic oncological effects of this treatment.

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The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion

Cited by 6 publications

References 13 publications

The application of mirabilite in traditional Chinese medicine and its chemical constituents, processing methods, pharmacology, toxicology and clinical research

The application of mirabilite in traditional Chinese medicine and its chemical constituents, processing methods, pharmacology, toxicology and clinical research

Quyu Xiaozhong recipe exerts anti-inflammatory effect in acute mastitis by inhibiting TLR4/NF-κB signal pathway

Hyperthermic intrathoracic chemotherapy for the treatment of malignant pleural effusion caused by breast and ovarian cancer: A systematic literature review and pooled analysis

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