The Clinical Evaluation of Aureomycin 123

Brainerd, Henry; Lennette, Edwin H.; Meiklejohn, Gordon; Bruyn, Henry B.; Clark, William H.

doi:10.1172/jci102191

Cited by 56 publications

(7 citation statements)

References 25 publications

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“…faecalis, micro-aerophilic streptococci, and penicillin-resistant Str. viridans; but results have been disappointing, for of 10 patients reported by various authorities (Brainerd, Lennette, Meiklejohn, Bruyn, and Clark, 1949;Harvey, Mirick, and Schaub, 1949;Dowling, Lepper, Caldwell, Whelton, and Sweet, 1949;Schoenbach, 1949) aureomycin failed to cure infection in six, and clearly succeeded in only two. Likewise, in Cases 1 and 2 infection returned after treatment with aureomycin, although the organisms in both were sensitive to this antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Penicillin-resistant Bacterial Endocarditis Treated by Penicillin and Streptomycin

Cates¹,

Christie²,

Garrod³

1951

BMJ

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Section: Discussionmentioning

confidence: 99%

Penicillin-resistant Bacterial Endocarditis Treated by Penicillin and Streptomycin

Cates¹,

Christie²,

Garrod³

1951

BMJ

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“…Case (1949) has described good results in one patient, and Brainerd et al (1949) were impressed by the rapid improyement of a case of herpes ophthalmicus similarly treated. In view of these claims and in spite of the difficulties of assessing the effects of treatment on a syndrome of such varying severity as herpes zoster, the following small controlled investigation was carried out.…”

Section: Discussionmentioning

confidence: 99%

Investigation into the Effects of Aureomycin and Chloramphenicol in Herpes Zoster

Ab¹

1951

BMJ

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MZM~~~~~~~~~~~~CAL JOUm"A have found that different batches of the same brand of wool may yield significantly different survital patterns for most Gram-positive organisms. However, if we substitute serum swabs for the usual plain type then the first factor is automatically removed and the second becomes less critical. As a result, estimates of survival time on serum swabs may be accepted with greater confidence than those applying to untreated swabs.Assuming a moderately heavy contamination of a serum swab (this is an important variable impossible to control clinically), we suggest that an examination may be expected to yield a valid result when cultured within the following time limits: (1) (Table II), we do not recommend delaying plating longer than eight hours. In some clinical cases which we have examined [he organisms failed to survive 24 hours on serum swabs. Although autoclaved albumin-dipped swabs have not been studied so exhaustively the results were similar to those achieved with serum.We have attempted to discover how serum prolongs survival, but without success. For instance, it could not be shown that serum inactivated a toxic lipoid or water-soluble agent in the wool or that it acted as a substrate for growth. The effect of serum protein is probably a physico-chemical one acting on tie bacterial cells and prolonging their survival irrespective of the materials on which they are lodged.It is felt that these findings may have a broader significance than the somewhat restricted object of this investigation:. Two facts are worthy of consideration from an epidemiological point of view. The first is the rapidity with which enteric pathogens die off when dried in air, and the second is that organisms leaving their hosts in serous exudates will live longer than those discharged in secretions of low protein content. These two points may throw some light on factors determining the survival of pathogenic organisms outside their natural hosts. SummaryA study has been made of the survival patterns of a large number of organisms on plain swabs undet standard laboratory conditions. From this study the

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“…During the past year a number of papers have described the clini cal effectiveness of aureomycin in the treatment of bacterial, rickettsial, and viral diseases (131, 147 to 151). Of particular interest is the action of aureo mycin on the viruses responsible for lymphogranuloma inguinale, psittacosis, and primary atypical pneumonia (147,148,150). These results are encourag ing as far as chemotherapy of virus infections is concerned, although Herrell (147) pointed out that the first two viruses are large ones intermedi ate between rickettsiae and other viI:uses, and that aureomycin is not ef fective in the treatment of influenza, poliomyelitis, or the common cold.…”

Section: Cahsochoh·cb(nh2)·ch20hmentioning

confidence: 99%