The Clinical Features of Chronic Vitamin Deficiency

Brocklehurst, J. C.; Griffiths, Laura; Taylor, G. F.; Marks, John; Scott, D. L.; Blackley, Jacqueline

doi:10.1159/000245198

Cited by 53 publications

(10 citation statements)

References 5 publications

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“…Regardless of the aetiology of the vitamin C depletion, we feel that patients with malignancy should receive vitamin supplements. Studies in other clinical groups with low vitamin levels had indicated clinical benefit in patients who have received supplements (Brocklehurst et al, 1968) and one study (Dymock and Brocklehurst, 1973) reported an increased mortality in the group of patients not given therapeutic vitamin supplements.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

Krasner¹,

Dymock²

1974

Br J Cancer

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Summary.-In a study of the vitamin C status of 50 patients with malignant disease, 46 had leucocyte levels less than the lower limit of the normal range (18-50 ,ug/108 W.B.C.) and of these 30 had very low levels (< 12-5 jug/108 W.B.C.). Physical signs compatible with subclinical scurvy were frequently recorded and there was a significant decrease in capillary fragility in those with the lowest levels. Most patients had an inadequate dietary intake of ascorbic acid-containing foods and this was felt to be the major factor in producing the vitamin depletion.

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Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

Krasner¹,

Dymock²

1974

Br J Cancer

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“…Thiamin intakes below current guidelines have been associated with clinical problems in elderly patients (Older & Dickerson 1982). Non dietary factors may obscure the relationship between riboflavin intake and biochemical status (Rutishauser et al, 1979) and clinical signs are unreliable evidence of deficiency (Brocklehurst et al, 1968;MacLeod, 1972). Non dietary factors may obscure the relationship between riboflavin intake and biochemical status (Rutishauser et al, 1979) and clinical signs are unreliable evidence of deficiency (Brocklehurst et al, 1968;MacLeod, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…A variable incidence of biochemical riboflavin deficiency has been reported: from 7% (Vir & Love, 1979) to 20% (Thurnham, 1972). Non dietary factors may obscure the relationship between riboflavin intake and biochemical status (Rutishauser et al, 1979) and clinical signs are unreliable evidence of deficiency (Brocklehurst et al, 1968;MacLeod, 1972). Requirements for thiamin (Oldham, 1962) and vitamin B6 (Guilland et al, 1984) may increase with age.…”

Section: B Vitamins In Hospital Meals Low Intake In Elderly 315mentioning

confidence: 99%

The B vitamin content of hospital meals and potential low intake by elderly inpatients

Thomas¹,

Finglas²,

Bunker³

1988

J Human Nutrition Diet

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The content of thiamin, riboflavin, vitamin B6 (pyridoxamine, pyridoxal, pyridoxine), niacin and total folate were determined in the meal choices comprising a typical day's menu in a teaching hospital. Thiamine, riboflavine, and B6 were measured by HPLC analysis, folate by microbiological assay, and niacin content was calculated from food tables. The results were compared with UK Recommended Daily Amounts (RDA) whenever possible (thiamine, riboflavine and niacin). Vitamin B6 and folate results were compared with the US Recommended Daily Dietary Amount (RDDA) as no British recommendation was available. Elderly inpatients selected meals which, even if completely consumed, provided half the current recommendation for vitamin B6 and one‐third of the recommendation for folate. More than half the meal selections provided less than recommended amounts of riboflavine, and in a quarter of cases less than the recommended amount of thiamine.

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“…On present inspection, the manuscript records of the clinical observer are clearly those written at the time of clinical examination without subsequent revision or alteration. Although Brocklehurst et al (1968) obtained highly significant statistical differences for values of Hess tests at the end of their trial between treated and control groups, Griffiths (1968) was unable to show an association between the Hess test and ascorbic acid deficiency designated as less than 24/pg per 108 white blood cells (WBC). Twenty-six of the controls who were still in hospital were Hess-tested 6 months after the conclusion of the trial.…”

Section: Leucocytementioning

confidence: 99%

“…The clinical studies By the courtesy of Dr G. F. Taylor, I have been able to examine his original records of a controlled study which has been previously reported (Griffiths, Brocklehurst, Scott, Marks & Blackley, 1967;Brocklehurst, Griffiths, Taylor, Marks, Scott & Blackley, 1968;Griffiths, 1968;Taylor, 1968). I n this study of eighty elderly hospital patients selected at random, forty were given a daily multivitamin tablet containing 200 mg ascorbic acid for a year and forty controls were given a placebo.…”

mentioning

confidence: 99%

A study of the relationship between Hess tests and leucocyte ascorbic acid in a clinical trial

Eddy

1972

Br J Nutr

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I .The results of a previously reported controlled trial of vitamin supplementation of elderly hospital patients, in which capillary resistance was measured by the Hess test, were examined and analysed statistically.2. Capillary resistance was reduced during successive 3-monthly tests over a period of IZ months and the reduction was related to leucacyte ascorbic acid concentration.3. It is postulated that the rate of recovery from capillary trauma inflicted by the test was dependent upon the function of ascorbic acid in the hydroxylation of proline to hydroxyproline during collagen synthesis.Since Hess (1913) first described the appearance of 'numerous little haemorrhages ' after the application of a sphygmomanometer cuff at a pressure of 80 mm Hg for 3 min to the arms of children suffering from infantile scurvy, many workers have used the test with various modifications and with contradictory results. Most properly controlled studies in which capillary resistance was related to blood and tissue concentrations of ascorbic acid have been unable to demonstrate a useful relationship between the test and vitamin status, but there have been notable exceptions. Gothlin (1931, 1933) was able to relate the results of the test to vitamin deficiency, and the most striking example of contradiction is the appendix by Scarborough to the report by Bartley, Krebs & O'Brien (1953) of the Sheffield study of experimental scurvy. Scarborough's Hess tests showed abnormal results in all but one of ten scorbutic young subjects, but the main report of the same investigation found no such relationship. The subject has been reviewed by Munro, Lazarus & Bcll(1947-8) and recently Krasner & Dymock (1970), using the I-Iess test and a negative pressure angiosterrometer, came to the conclusion that capillary resistance is independent of buffy layer ascorbic acid.The clinical studies By the courtesy of Dr G. F. Taylor, I have been able to examine his original records of a controlled study which has been previously reported (Griffiths, Brocklehurst, Scott, Marks & Blackley, 1967;Brocklehurst, Griffiths, Taylor, Marks, Scott & Blackley, 1968;Griffiths, 1968;Taylor, 1968). I n this study of eighty elderly hospital patients selected at random, forty were given a daily multivitamin tablet containing 200 mg ascorbic acid for a year and forty controls were given a placebo. Measurements of leucocyte ascorbic acid were made at 3-monthly intervals. Hess tests were performed at the same time by applying a sphygmomanometer cuff to the right arm at a pressure of IOO mm Hg for 5 min and counting petechiae appearing in a circle of skin of 25 mm.https://www.cambridge.org/core/terms. https://doi

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The Clinical Features of Chronic Vitamin Deficiency

Cited by 53 publications

References 5 publications

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

The B vitamin content of hospital meals and potential low intake by elderly inpatients

A study of the relationship between Hess tests and leucocyte ascorbic acid in a clinical trial

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