The clinical features of posterior scleritis with serous retinal detachment: a retrospective clinical analysis

Choroidal involvement in non-infectious posterior scleritis

“…In a retrospective review published by Ando et al subfoveal choroidal thickness, measured with EDI-OCT, was increased at presentation; and decreased with successful treatment during the follow-up period (mean choroidal thickness at presentation was 611 ± 148 μm, decreasing to 298 ± 75 μm (p < 0.01) at 1 month, and further decreasing afterwards) [14]. Dong and colleagues reported similar findings in a retrospective study of 23 patients with posterior scleritis and concurrent serous retinal detachment [20]. This case series showed an average subfoveal choroidal thickness with EDI-OCT of 442.61 ± 55.6 μm in the affected eye and 246 ± 42.3 μm in the unaffected eye (p < 0.01) and reported a significant correlation between subfoveal choroidal thickness and posterior coats thickness (as measured on B-scan ultrasound; r = 0.783, p < 0.001) and between subfoveal choroidal thickness and axial length (r = − 0.65, p = 0.001).…”

“…In this retrospective study, a relatively young age at disease onset was reported (mean age 29.5 years old). Anterior scleritis was present in 52.0% of cases, which seems to be higher than in reports of posterior scleritis without serous retinal detachment [20]. Interestingly, Dong and colleagues reported that 74% of the patients in their study were initially misdiagnosed, underlining the importance of taking into account the clinical and imaging characteristics in such cases.…”

“…Benson and colleagues divided the clinical signs in their case series of posterior scleritis into different categories: 6 patients were observed to have choroidal folds, 7 patients had retinal striae and 1 had disc edema; furthermore an annular choroidal detachment was found in 7 patients, an exudative macular detachment in 15 patients, and a peripheral retinal detachment in one patient [15]. Dong et al analyzed the clinical features of patients with a serous retinal detachment due to posterior scleritis [20]. In this retrospective study, a relatively young age at disease onset was reported (mean age 29.5 years old).…”

“…It is an uncommon condition, affecting between 2.0 and 17.7% of all scleritis patients in retrospective epidemiological studies [2][3][4][5][6][7][8][9][10][11][12]. Posterior scleritis is reported to have a female preponderance in the majority of case series and can occur in all decades of life (Table 1) [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Immunopathological Analysis of a Mouse Model of Arthritis-Associated Scleritis and Implications for Molecular Targeted Therapy for Severe Scleritis

“…B-mode ultrasonography shows scleral thickening, scleral nodules, dissection of the Tenon capsule from the sclera, and exophthalmos [ 9 ]. Optical coherence tomography (OCT) shows optic papillary oedema, choroidal folds at the posterior pole, and exudative retinal detachment, and imaging is useful for diagnosis and the evaluation of disease activity [ 10 , 11 , 12 ]. Anterior scleritis and uveitis may also be present [ 13 , 14 , 15 ].…”