The clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma

Fukutsu, Kanae; Kase, Satoru; Ishijima, Kan; Kinoshita, Rumiko; Ishida, Susumu

doi:10.1186/s13014-018-1045-7

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…16 A few limited case series describing incidence and surgical outcomes of phacoemulsification after EBRT for ocular adnexal mucosa-associated lymphoid tissue lymphoma are described in the literature. 8,9,13,14,16…”

Section: Discussionmentioning

confidence: 99%

“…Although this cohort is at an increased risk for early cataract development requiring surgery, surgical outcomes have been described in only very limited case series of 8 to 11 patients because of the generally low-risk profile of cataract surgery. 8,9,11 Despite this low risk, it is known that certain patients are at a greater risk for complication, including, among many others, those with PC plaques. Grading systems that have been developed to quantify the risk for complication after cataract surgery do not consider the potential risk for surgery in eyes treated with previous radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…4 The cataract surgery outcomes of adult patients who have previously received EBRT have not been well described, despite these patients being known to be at an increased risk for developing cataract requiring surgery. 8,9 Understanding the risk profile of cataract surgery in this specific cohort is essential to appropriately counsel patients of the surgical risks. This study aimed to quantify the outcomes of cataract surgery in patients who previously received EBRT and compare them with a national cohort.…”

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confidence: 99%

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Outcomes of cataract surgery in patients previously treated with orbital radiotherapy

Hind

Jamison

Schipani

et al. 2022

J Cataract Refract Surg

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To quantify the risks for cataract surgery in patients who have previously undergone external beam radiotherapy (EBRT).Setting: Tertiary ophthalmology and oncology hospital.Design: Retrospective case series.Methods: Patients treated with orbital EBRT at the Beatson West of Scotland Cancer Centre between 2001 and 2019 were identified, and clinical records were reviewed to identify those who had subsequently undergone cataract surgery. Preoperative and postoperative case records, and operation records, were reviewed to identify demographic data and data regarding complications and surgical outcomes.Results: 46 eyes (of 33 patients) were included. The indications for EBRT included thyroid eye disease, lymphoma, choroidal metastases, and other orbital malignancies. Mean corrected

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Outcomes of cataract surgery in patients previously treated with orbital radiotherapy

Hind

Jamison

Schipani

et al. 2022

J Cataract Refract Surg

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“…Previous studies showed that more than half of patients receiving RT without a lens shield had cataract within 3-9 years following RT. [ 30,33] Cataract is the most common late morbidity in ocular adnexal MALT lymphoma patients treated with RT. The risk of cataract and the latent period between RT and appearance of cataract are dose dependent.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy alone for stage IE ocular adnexal mucosa-associated lymphoid tissue lymphomas: long-term results

et al. 2020

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Background: To evaluate the long-term efficacy and toxicity of radiation therapy in patients with Stage IE primary ocular adnexal mucosa-associated lymphoid tissue lymphoma. Methods: We designed a retrospective analysis to evaluate 81 patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy between 2006 and 2016. The median radiation dose was 30 Gy (range, 30-36 Gy in 15-18 fractions). Local control, progression-free survival, overall survival, and cumulative incidence of Grade 3 cataract were calculated by using the Kaplan-Meier method. Result: The median follow-up time was 74 months (range, 4-157 months). The 5-year local control was 100%. Although local relapse was suspected in 3 patients after radiation therapy, 2 patients were pathologically diagnosed as IgG4-related inflammation and in 1 patient as intense inflammatory cell infiltration. The 5-year progression-free survival was 94.4%. Five patients had relapse at distant sites. The 5-year overall survival was 98.8%. Twenty patients had Grade 3 cataract. The 5-year cumulative incidences of Grade ≥ 3 and Grade ≥ 2 cataract for 58 patients treated without a lens shield were 38 and 40%, respectively. The incidence of Grade ≥ 3 cataract was 42% for 50 patients treated with 6-MV X-rays (estimated lens dose: 29 Gy) and 17% for 8 patients treated with 9-MeV electrons (estimated lens dose: 24 Gy). Conclusions: Radiation therapy alone yielded excellent local control and long-term survival in Stage IE ocular adnexal mucosa-associated lymphoid tissue lymphoma. Long-term observation with careful attention to relapse at distant sites is necessary. In the case of suspected local relapse, IgG4-related disease should be carefully ruled out.

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“…2 However, in proportion with the efficacy of RT, adverse events such as dry eye, cataract, and retinopathy can occur following. 3,4 The optimal RT dose for the treatment of OAML that can effectively control the tumor and minimize ocular complications at the same time is not yet well established. Recently, some researchers have suggested ultra-low-dose RT (4 Gy) for management of ocular adnexal B-cell lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Ultra-low-dose radiation treatment for early-stage ocular adnexal MALT lymphoma

Lee

Choe

et al. 2021

European Journal of Ophthalmology

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Purpose: To investigate the long-term outcomes of ultra-low-dose (4 Gy) radiation treatment (RT) in patients with early-stage ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: This retrospective case series includes eight patients with ocular adnexal MALT lymphoma who received ultra-low-dose RT at a single tertiary referral center between March 2016 and February 2018. Response to treatment and the time taken to respond were analyzed. Results: Of the eight patients (three men, five women), seven patients had conjunctival lymphoma (T1N0M0), and one patient had orbital lymphoma (T2N0M0). Six patients with T1 disease showed complete response (CR), and the median time to CR was 4.5 months (range 2–5). Partial response was achieved in the remaining two patients (one each with T1 and T2). During the median follow-up period of 44 months (range 30–54), none of the patients had a relapse or needed additional treatment. RT was well-tolerated in all patients with no ocular complications, including cataracts and dry eye. Conclusion: This case series suggests that ultra-low-dose RT is effective and well-tolerated in patients with early-stage ocular adnexal MALT lymphoma. Further studies with a larger sample size and long-term follow-up are needed to evaluate the local control rate and disease-free survival precisely.

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The clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma

Cited by 9 publications

References 22 publications

Outcomes of cataract surgery in patients previously treated with orbital radiotherapy

Outcomes of cataract surgery in patients previously treated with orbital radiotherapy

Radiotherapy alone for stage IE ocular adnexal mucosa-associated lymphoid tissue lymphomas: long-term results

Ultra-low-dose radiation treatment for early-stage ocular adnexal MALT lymphoma

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