The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Benson, Eleni; Li, Ryan; Eisele, David W.; Fakhry, Carole

doi:10.1016/j.oraloncology.2013.09.008

Cited by 222 publications

(209 citation statements)

References 113 publications

(217 reference statements)

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“…Our finding that 3-year actuarial overall survival for elderly HPV+ patients is around 85.5% is similar to findings from previous studies, which included individuals of all ages (11)(12)(13). Notably, our cohort of older individuals had a relatively high incidence of tobacco use, which may negatively alter the diseasecourse.…”

Section: Discussionsupporting

confidence: 87%

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Dave

Gupta

et al. 2017

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Section: Discussionsupporting

confidence: 87%

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Dave

Gupta

et al. 2017

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“…As p16 INK4A has been reported to be further regulated by epigenetic control and multiple transcription factors or gain of function in chromosome 11q, 48 it is likely that HPV-negative and HPV-positive anal cancers with low viral load share comparable genetic alterations or epigenetic methylation profiles that might result in reduced sensitivity to RT/CRT and worse prognosis. 32,49,50 We would like to acknowledge the limitations of our study. Although the patient number is relatively large (n 5 95), these data need to be validated prospectively in a larger patient cohort.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

Human papillomavirus DNA load and p16^INK4aexpression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy

et al. 2014

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As the detection rate of HPV-DNA in anal carcinoma commonly exceeds 90%, a comparison between sole HPV-positive and HPV-negative cancers with respect to treatment response following chemoradiotherapy (CRT) and long-term oncological outcome is challenging. Against this background, we aimed to assess HPV types and HPV DNA load in formalin-fixed paraffinembedded tissue (FFPE) of 95 patients treated with standard CRT for anal cancer to correlate viral load ( /> median) with local failure, distant metastases, cancer-specific (CSS) and overall survival (OS) rates. Various clinicopathologic parameters and the immunohistochemical marker p16 INK4a were evaluated for any correlation with HPV16 DNA load and were included in uni-and multivariate analyses. The overall prevalence of HPV DNA was 95.8% with HPV16 monoinfection being the most commonly encountered HPV type (78.9%), followed by HPV16 and 31,35,39,44, 58, 66 and 81 dual infection in 9 patients (9.5%). HPV16 DNA load was significantly associated with p16 INK4a expression (p 5 0.001). Patients with HPV16 DNA load median and low p16 INK4a expression showed significantly worse local control (HPV16 DNA load: univariate p 5 0.023, multivariate p 5 0.042; p16 INK4a : univariate p 5 0.021), and OS (HPV16 DNA load: univariate p 5 0.02, multivariate p 5 0.03). Moreover, a combined HPV16 DNA load and p16 INK4a variable revealed a significant correlation to decreased local failure, and increased CSS and OS (p 5 0.019, p 5 0.04 and p 5 0.031). In conclusion, these data indicate that HPV16 DNA load and p16 INK4a expression are significant prognostic factors for local tumor control and overall survival of patients with anal SCC following CRT.The majority of anal squamous cell carcinoma (SCC) is considered to originate from infection with human papilloma viruses (HPV). 1,2 Especially the role of high-risk oncogenic HPV types, most prominently HPV type 16 (HPV16), in the etiology of anal SCC is well established by a multitude of epidemiological and experimental investigations. 3,4 As a consequence, technologies for the detection of HPV DNA may constitute valuable screening tools for anal malignancies and are of important clinical relevance, especially after the development of a preventive vaccine for both men and women. 5 Depending on the method used, the prevalence of HPV DNA in anal carcinoma ranges from 75% to 100% with HPV16 (>75%) and less frequent HPV18 (<10%) detection in the majority of cases. 6,7 In clinical series of head and neck as well as cervical SCC, recent data indicate that treatment response to radiotherapy (RT) or chemoradiotherapy (CRT) is superior in HPV-positive tumors as compared with their HPV-negative counterparts. [8][9][10] An increased sensitivity of HPV-positive tumor cells towards irradiation and chemotherapeutic agents was also observed in vitro and in animal studies. [11][12][13] However, as the detection rate of HPV DNA in anal SCC commonly exceeds 90%, a comparison between sole HPV-positive and HPV-negative cancers with respect to treatment respon...

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“…This trend may be ascribed to several factors, such as smoking and alcohol consumption, which are well known risk factors of HNSCC. However, more significant effects occur presently, namely the growing elderly population as well as a considerable increase in human papilloma virus (HPV)-induced oropharyngeal carcinoma [4,5] which is now the most common HNSCC in this country.…”

mentioning

confidence: 99%

Trends in cancer of the head and neck in the elderly in Denmark, 1980–2012

Johansen

Eriksen

2016

Acta Oncologica

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Background Squamous cell carcinoma of the head and neck (HNSCC) comprises a variety of malignant tumors. Due to the rarity of each individual malignant entity, knowledge of epidemiological changes and trends over time may be derived from data compiled in regional and national registries. This study analyzed the development in incidence rates and mortality in elderly HNSCC patients in Denmark between 1980 and 2012 with specific attention to compliance to radiotherapy, the main treatment modality of HNSCC in Denmark. Material and methods HNSCC consisting of more than 25 patients per year over the age of 70 years were analyzed. This included cancer of the oral cavity defined as ICD-codes C00.3-4, C02-04, C05.0, C06; oropharynx as C01, C05.1-9, C09-10; and larynx as C32 recorded in the NORDCAN database. Additional data from the DAHANCA database was added to assess differences in compliance to treatment between younger and older patient groups. Results HNSCC was predominant in younger patients. Only 17% were older than 70 years. The median age was 60 years. Generally, incidence rates rose for cancer of the oral cavity and oropharynx between 1980 and 2012 and stabilized for laryngeal cancer. Mortality rates had a shallower increase, especially in younger age groups, which translated into improved age-specific survival rates. Compliance to radiotherapy was high for all age groups. Failure to receive at least 60 Gy during radical radiation treatment was 2.3% despite a significant increase in patients with poor WHO performance status over time. Conclusion HNSCC is a rare disease in patients above 70 years accounting for only 17% of all HNSCC patients. Incidence rates increased over time, but age-specific survival rates improved, especially in younger patients. Failure rates to comply with radiation treatment, however, were low in both young and elderly patients.

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The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Cited by 222 publications

References 113 publications

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Human papillomavirus DNA load and p16^INK4aexpression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy

Trends in cancer of the head and neck in the elderly in Denmark, 1980–2012

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The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

Cited by 222 publications

References 113 publications

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Human Papilloma Virus-positive Oropharyngeal Squamous Cell Carcinoma in the Elderly

Human papillomavirus DNA load and p16INK4aexpression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy

Trends in cancer of the head and neck in the elderly in Denmark, 1980–2012

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Human papillomavirus DNA load and p16^INK4aexpression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy