2023
DOI: 10.14309/ajg.0000000000002400
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The Clinical Impact of Obesity in Patients With Disorders of Defecation: A Cross-Sectional Study of 1,155 Patients

Abstract: Objectives Obesity is a global epidemic. Its clinical impact on symptoms of fecal incontinence (FI) and/or constipation and underlying anorectal pathophysiology remains uncertain. Methods Cross-sectional study of consecutive patients meeting Rome IV criteria for FI and/or functional constipation, with data on body mass index (BMI), attending a tertiary center for investigation between 2017-2021. Clinical history, symptoms and anorectal physiologic test results were analyzed accord… Show more

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Cited by 4 publications
(2 citation statements)
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“…Still, the authors noted a higher prevalence of rectoceles amongst patients with obesity, albeit not statistically significant due to the limited number of patients undergoing defecography. Another recent single-center study revealed significantly higher odds of clinically significant (>4 cm) rectoceles as assessed by defecography in patients with obesity compared to patients with normal BMI, although no differences in rectal sensory thresholds were observed [10]. Patients who were obese had a significantly higher odds performing specific interventions such as manual maneuvers to facilitate defecation, compared with patients with a normal BMI, aligned with an older study demonstrating that a sense of obstruction and use of digital maneuvers were specific (though not sensitive) for the presence of an anorectal structural disorder [11].…”
Section: Discussion and Future Directionsmentioning
confidence: 91%
“…Still, the authors noted a higher prevalence of rectoceles amongst patients with obesity, albeit not statistically significant due to the limited number of patients undergoing defecography. Another recent single-center study revealed significantly higher odds of clinically significant (>4 cm) rectoceles as assessed by defecography in patients with obesity compared to patients with normal BMI, although no differences in rectal sensory thresholds were observed [10]. Patients who were obese had a significantly higher odds performing specific interventions such as manual maneuvers to facilitate defecation, compared with patients with a normal BMI, aligned with an older study demonstrating that a sense of obstruction and use of digital maneuvers were specific (though not sensitive) for the presence of an anorectal structural disorder [11].…”
Section: Discussion and Future Directionsmentioning
confidence: 91%
“…Consistent with previous studies 21,23,24 our data show that age, gender and BMI can significantly influence anorectal physiology and response to BET. Considering the gender differences in anorectal physiology, we conducted an additional analysis specifically focusing on gender‐related differences.…”
Section: Discussionmentioning
confidence: 91%