2020
DOI: 10.4081/reumatismo.2020.1275
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The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces

Abstract: The antisynthetase syndrome (ASS) is clinically characterized by fever, myositis, interstitial lung disease, joint involvement, mechanic’s hands, or Raynaud’s phenomenon, and the presence of antisynthetase autoantibodies. These clinical manifestations may not occur simultaneously. Therefore, the aim of this study was to analyze the sequence in which these clinical manifestations can develop at the onset of ASS. This retrospective, single-center cohort study enrolled 55 ASS patients. Their mean age at the onset… Show more

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Cited by 16 publications
(27 citation statements)
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“…Over time, however, most patients developed further symptoms, and by the end of the follow-up, the vast majority of patients had either the classic triad of symptoms or at least two symptoms coexisting [14]. The different timing of symptom onset was also demonstrated in a retrospective study analysing 55 patients with antisynthetase syndrome hospitalised in a Brazilian centre [18]. In the described cohort, the most common first symptom of the disease was joint complaints, observed in 43.6% of patients.…”
Section: The Different Timing Of Onset Of Symptomsmentioning
confidence: 83%
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“…Over time, however, most patients developed further symptoms, and by the end of the follow-up, the vast majority of patients had either the classic triad of symptoms or at least two symptoms coexisting [14]. The different timing of symptom onset was also demonstrated in a retrospective study analysing 55 patients with antisynthetase syndrome hospitalised in a Brazilian centre [18]. In the described cohort, the most common first symptom of the disease was joint complaints, observed in 43.6% of patients.…”
Section: The Different Timing Of Onset Of Symptomsmentioning
confidence: 83%
“…Diagnosis of the disease is complicated by the fact that not all symptoms are necessarily present in every patient, and complaints may appear at different times [14,18,19]. A trend towards the progression of the clinical picture over time was noted in an observational study on a group of 828 patients with antisynthetase antibodies from the AENEAS (American and European NEtwork of Antisynthetase Syndrome) registry [14].…”
Section: The Different Timing Of Onset Of Symptomsmentioning
confidence: 99%
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“…The anti-JO1 is the most frequently identified. More rarely, anti-PL-12, PL-7, EJ, OJ, KS, ZO, YRS, JS, and SC can be involved [1][2][3]7 Specific MSA identification is important because of their association with clinical specificities, forming clinical subgroups. 3,4 Muscle biopsy (after magnetic resonance imaging) can be useful when the diagnosis is difficult and shows relatively homogeneous anomalies regardless of the ASS subgroup.…”
Section: Discussionmentioning
confidence: 99%
“…Antisynthetase syndrome (ASSD) is a rare systemic autoimmune myopathy that is defined by the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) autoantibodies. Clinically, ASSD is characterized by myositis, arthritis, and interstitial pneumopathy, in addition to "mechanic's hands," Raynaud's phenomenon, or fever (1)(2)(3)(4). Myositis has a broad phenotypic spectrum among individuals with ASSD, ranging from increased serum levels of muscle enzymes in asymptomatic patients or isolated myalgia to severe muscle weakness in bedridden patients (5).…”
Section: Introductionmentioning
confidence: 99%