The Clinical Observation of Acupuncture Combined With Antiemetic Drugs in the Prevention and Treatment of CINV in Breast Cancer Patients

Abstract

ObjectiveThe present study aimed to explore the effectiveness of acupuncture combined with antiemetic drugs in prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) among breast cancer patients receiving postoperative adjuvant chemotherapy. MethodsWe retrospectively collected the clinical records of 81 postoperative breast cancer patients at our hospital from January 2021 to December 2021. These patients were divided into the acupuncture group and the control group. The efficacy of the antiemetic drugs combined with acupuncture for CINV was analysed. The primary endpoints were total, acute, and delayed nausea and vomiting grade and remission rate. Safety and overall patient quality of life were secondary endpoints.ResultsDuring the whole observation period, compared with the control group, the frequency of nausea and vomiting was decreased in the acupuncture group (P=0.034). And the ECOG-PS score in the acupuncture group was significantly improved (P=0.004). In addition, the adverse events, such as abdominal (12.2% vs. 5.0%, P=0.252), distention (19.5% vs. 5.0%, P=0.049), and diarrhea (9.7% vs. 0, P=0.044), were decreased by acupuncture.ConclusionsAcupuncture combined with antiemetics could reduce the incidence of CINV, improve the quality of life of patients and reduce the incidence of adverse side effects of antiemetic drugs.

Acupuntura Na Redução De Náusea E Vômito Em Mulheres Com Câncer De Mama Em Quimioterapia

“…Kong et al (21) PUBMED 6 Efeitos da TENS nos sintomas eméticos e seus desfechos em mulheres com câncer de mama durante a quimioterapia.…”

“…Sugere-se a utilização da mesma em conjunto com métodos farmacológicos.3(19) Os achados ainda são incipientes no que tange aos efeitos e à padronização dos parâmetros utilizados pela eletroestimulação. E demonstram que a abordagem da TENS não tem efeito no controle dos sintomas de naúsea e vômito provocados pelo tratamento quimioterápico, bem como na amostra de antieméticos na amostra estudada.4(20) Houve significativa diminuição de náusea e vômitos pelo grupo experimental, concluindo que a auriculoterapia nos pontos recomendados pode aliviar as náuseas e vômitos induzidos pela quimioterapia sem produzir quaisquer efeitos secundários.5(21) Durante todo o período de observação, em comparação com o grupo controle, a frequência de náuseas e vômitos diminuiu no grupo de acupuntura. E a pontuação ECOG-PS no grupo de…”

Development and Validation of an Auricular Acupuncture Protocol for the Management of Chemotherapy-Induced Nausea and Vomiting in Cancer Patients

“…Furthermore, in addition to the risk of potential medication interactions with antineoplastic regimens, the excessive use of pharmacological interventions increases the financial burden on patients and public healthcare systems [6]. In light of this, it is worth exploring the role of nonpharmacological methods for the management of CINV as complementary approaches to pharmaceutical agents [7][8][9].…”

Evaluation of acupuncture and auriculotherapy in the control of chemotherapy-induced nausea and vomiting: a Pilot Study

“…An observational study explored the effectiveness of acupuncture combined with antiemetic drugs in preventing and treating CINV in patients with breast cancer using postoperative adjuvant chemotherapy (anthracycline and cyclophosphamide), comparing a control group (CG) with an antiemetic protocol and an acupuncture group with an antiemetic regimen combined with acupuncture. Over the five days of the study, the number of patients without CINV or post-CT vomiting or nausea only increased, and the number with CINV or vomiting only decreased in the acupuncture group (p = 0.046) ( 14 ) .…”