The clinical patterns of myalgia in children with familial Mediterranean fever

Majeed, H. A.; Al-Qudah, Abdelkarim A.; Qubain, H.; Shahin, H.M.

doi:10.1053/sarh.2000.16646

Cited by 69 publications

(51 citation statements)

References 24 publications

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“…They proposed criteria for a working diagnosis including: severe disabling myalgia of at least 5 days in a young patient with FMF, associated with fever, elevated levels of infl ammatory markers and the presence of at least one M694V mutation (10). However, it was also reported that PFM may occur as a fi rst attack before being diagnosed as having FMF (2,6,10,11). Similarly, in our patient, the fi rst FMF attack was characterised by PFM.…”

Section: Discussionsupporting

confidence: 75%

“…The episode lasts for 4-6 weeks, except in those patients treated with corticosteroids. High ESR, hyperglobulinemia, normal CPK, and subtle nonspecifi c infl ammatory myopathic changes on EMG are the other characteristics (1,2). In this report, we present a child with PFM as the sole feature preceding the diagnosis of FMF and draw attention to the PFM for the diagnosis of FMF even the patient does not fulfi ll the criteria for the clinical diagnosis.…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Protracted Febrile Myalgia In A Child As The Presenting Sign Of Familial Mediterranean Fever: Case Report And Review Of The Literature

Gökçe¹,

Demirkaya²,

Gök³

2009

TUTFD

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 87%

Protracted Febrile Myalgia In A Child As The Presenting Sign Of Familial Mediterranean Fever: Case Report And Review Of The Literature

Gökçe¹,

Demirkaya²,

Gök³

2009

TUTFD

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“…It can be said that this psychological factor is anxiety sensitivity. FMF is a disease characterized by episodes of abdominal pain, which can adversely affect functionality (33,34). Patients might avoid situations that cause this pain (35), and patients with FMF may exhibit avoidance or precautionary behaviors, believing that they can reduce or stop pain in this way.…”

Section: Discussionmentioning

confidence: 99%

Effect of familial Mediterranean fever on sexual and reproductive health in women

Uğurlu¹,

Uğurlu²,

Erten³

et al. 2017

Turk J Med Sci

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The aim of this study was to investigate the relationship between familial Mediterranean fever and female sexual dysfunction and premenstrual syndrome. Materials and methods:This study included 36 patients with familial Mediterranean fever and 33 healthy volunteers. Familial Mediterranean fever was diagnosed according to the Tel Hashomer criteria and familial Mediterranean fever mutations were identified in all of the patients. The patients and healthy volunteers were compared in terms of anxiety, depression, sexual dysfunction, and premenstrual syndrome, and a model was created that describes the relationships among these variables. Results:We found statistically significant differences between the groups in terms of anxiety, premenstrual syndrome, and Golombok Rust Inventory of Sexual Satisfaction frequency and vaginismus subscale scores. There was no difference in depression scores between the groups. Conclusion:Familial Mediterranean fever is a rheumatic disease that predisposes patients to sexual dysfunction and premenstrual syndrome, which emerges as direct and indirect psychological factors.

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“…10,11 The syndrome PFMS is a form of myalgia that may occur in patients who have FMF, and is characterized by severe paralyzing myalgia, high fever, abdominal pain, diarrhea, arthritis or arthralgia, and transient vasculitic rashes mimicking Henoch-Schönlein purpura. [12][13][14][15][16][17][18][19][20] The earliest description of PFMS in patients who have FMF was in 1994, and PFMS has been reported in sporadic case reports and 11% patients who have FMF. 12,14 The 5 Mediterranean fever gene (MEFV) mutations of the M694V gene may cause FMF and frequently occur in Arabs.…”

Section: Introductionmentioning

confidence: 99%

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Halim¹,

Al-Otaibi²,

Donia³

et al. 2015

Exp Clin Transplant

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Drug-induced toxic myopathy is a complication of familial Mediterranean fever in patients who receive colchicine, especially when combined with cyclosporine. Protracted febrile myalgia syndrome is a severe form of familial Mediterranean fever. A 34-year-old man who had familial Mediterranean fever for > 15 years developed kidney failure because of secondary amyloidosis. He received livingunrelated-donor kidney transplant that functioned normally. He was on colchicine prophylaxis that was continued after transplant, and he received immunosuppression induction with antithymocyte globulin and maintenance with prednisolone, mycophenolate mofetil, and cyclosporine. After 2 months, he presented with severe myopathy and elevated creatine kinase. Muscle biopsy showed evidence of drug-induced toxic myopathy, most likely caused by cyclosporine in combination with colchicine. Cyclosporine was replaced with sirolimus and colchicine was stopped. Symptoms partially improved and creatine kinase decreased to normal. The prednisolone dosage was reduced gradually to 5 mg daily. At 8 months after transplant, he was readmitted because of severe arthralgia, prolonged fever, pleuritic chest pain, diffuse abdominal pain, purpuric rash, macroscopic hematuria, proteinuria, and diarrhea. The C-reactive protein and erythrocyte sedimentation rate were elevated. The clinical diagnosis was recurrent familial Mediterranean fever presenting as protracted febrile myalgia syndrome. Despite the history of toxic myopathy, he was restarted on colchicine (0.5 mg, twice daily), and colchicine was well tolerated. There was marked improvement of most symptoms within several days. Follow-up 5 years later showed normal kidney graft function and no familial Mediterranean fever activity on colchicine prophylaxis. In summary, familial Mediterranean fever reactivation and protracted febrile myalgia syndrome after kidney transplant may be treated with colchicine and modulation of immunosuppressive therapy.

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The clinical patterns of myalgia in children with familial Mediterranean fever

Cited by 69 publications

References 24 publications

Protracted Febrile Myalgia In A Child As The Presenting Sign Of Familial Mediterranean Fever: Case Report And Review Of The Literature

Protracted Febrile Myalgia In A Child As The Presenting Sign Of Familial Mediterranean Fever: Case Report And Review Of The Literature

Effect of familial Mediterranean fever on sexual and reproductive health in women

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