The Clinical Picture of Major Depression in Children and Adolescents

Ryan, Neal D.; Puig-Antich, Joaquim; Ambrosini, Paul J.; Rabinovich, Harris; Robinson, Delbert G.; Nelson, Beverly; Iyengar, Satish; Twomey, Jan

doi:10.1001/archpsyc.1987.01800220016003

Cited by 564 publications

(273 citation statements)

References 38 publications

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“…For example, in a comparison of children and adolescents with major depressive disorder (MDD) hypersomnia was reported less commonly in the children (16%) as compared to the adolescents (34%). 25 Furthermore, in a study mentioned previously, in contrast to the association with anxiety, the association between symptoms of sleep problems and depression appeared to be weaker in children (correlation = .26) as compared to adolescents (correlation = .58). depression.…”

Section: Sleep and Depressionmentioning

confidence: 71%

Sleep, emotional and behavioral difficulties in children and adolescents

Gregory

Sadeh

2012

Sleep Medicine Reviews

592

389

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Section: Sleep and Depressionmentioning

confidence: 71%

Sleep, emotional and behavioral difficulties in children and adolescents

Gregory

Sadeh

2012

Sleep Medicine Reviews

592

389

View full text Add to dashboard Cite

“…Consistent with this, childhood depression has been associated with different neurobiological correlates than depression in adolescents (Kaufman et al 2001). There is also evidence that a reduced RewP observed in depressive disorders may be more specific to anhedonia (Foti et al 2014;Liu et al 2014), which some have found to be less common in younger children (Ryan et al 1987;Carlson and Kashani 1988). Our findings that both lifetime symptoms of depression and early-emerging DMDD are associated with an enhanced RewP raises the possibility that later-emerging symptoms of irritability characteristic of youth depression are also associated with enhanced reward sensitivity.…”

mentioning

confidence: 89%

Longitudinal Associations Between Preschool Disruptive Mood Dysregulation Disorder Symptoms and Neural Reactivity to Monetary Reward During Preadolescence

Kessel

Dougherty

Kujawa

et al. 2016

Journal of Child and Adolescent Psychopharmacology

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Objective: Reward-processing abnormalities are thought to be a key feature of various psychiatric disorders and may also play a role in disruptive mood dysregulation disorder (DMDD), a new diagnosis in DSM-5. In the current study, we used eventrelated potentials (ERP) sensitive to monetary gains (i.e., the reward positivity [RewP]) and losses (i.e., the N200) to examine associations between symptoms of DMDD during early childhood and later reward processing during preadolescence. Methods: To assess early emerging DMDD symptoms in a large longitudinal community sample (n = 373) of 3-year old children, we administered a diagnostic interview, Preschool Age Psychiatric Assessment (PAPA) with parents. At a later assessment, *6 years later, children completed a monetary reward task while an electroencephalogram (EEG) was recorded. Children's lifetime history of psychopathology was also assessed at that time using Kiddie-Schedule of Affective Disorders and Schizophrenia (K-SADS) with the child and parent. Results: Multiple regression analyses revealed that age 3 DMDD symptoms predicted an enhanced RewP to monetary rewards in preadolescence. This association is independent of demographics and lifetime history of symptoms of depression, any anxiety disorder, attention-deficit disorder, oppositional defiant disorder, or conduct disorder Conclusions: Early manifestations of DMDD in children as young as 3 years old predicted enhanced reward processing later in development. These findings add to the growing corpus of literature on the pathophysiology of DMDD, and underscore the predictive validity of preschool DMDD on a neural level.

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“…As a result, parental intervention may be preventing internalizing disorders from affecting treatment adherence in the younger age-group. Furthermore, internalizing disorders are also different in nature during adolescence compared with childhood, and this may play a role as well (32,33). For example, psychomotor retardation as a symptom of depression is more common in older adolescents than in younger children (34).…”

Section: Garrison Katon and Richardsonmentioning

confidence: 99%

The Impact of Psychiatric Comorbidities on Readmissions for Diabetes in Youth

2005

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OBJECTIVE—Comorbid psychiatric disorders have been associated with poorer disease outcomes in diabetic youth. Less is known, however, about the relationship between psychiatric disorders and repeat hospitalizations for youth with diabetes. RESEARCH DESIGN AND METHODS—We performed a retrospective cohort study using data from the Pediatric Health Information System, which included detailed discharge data from 37 noncompeting children’s hospitals in the U.S. Using logistic regression, we examined whether the presence of coded diagnoses for internalizing or externalizing disorders at an index hospitalization for diabetes was associated with increased risk for rehospitalization during follow-up (duration of follow-up ranged from 3 to 24 months). The analysis was stratified by age-groups, and we controlled for potential confounders including sex, age, race/ethnicity, type 1 versus type 2 diabetes, Medicaid status, intensive care unit utilization, length of stay during index admission, and duration of follow-up. RESULTS—Among adolescents aged 13–18, internalizing disorders were associated with significantly increased odds of rehospitalization (odds ratio 1.79 [95% CI 1.27–2.52]); the point estimate for externalizing disorders was similar, but the finding was not statistically significant at the α = 0.05 level (1.74 [0.96–3.15]). No significant association between psychiatric diagnoses and odds of repeat hospitalization was observed in diabetic children aged 5–12 years. CONCLUSIONS—Internalizing disorders are associated with increases in repeat hospitalizations for diabetes among adolescents. Future research is needed to explore the reasons for this finding, such as degree to which treatment nonadherence mediates this relationship and whether appropriate treatment of internalizing disorders results in improved diabetes outcomes and decreased readmissions.

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The Clinical Picture of Major Depression in Children and Adolescents

Cited by 564 publications

References 38 publications

Sleep, emotional and behavioral difficulties in children and adolescents

Sleep, emotional and behavioral difficulties in children and adolescents

Longitudinal Associations Between Preschool Disruptive Mood Dysregulation Disorder Symptoms and Neural Reactivity to Monetary Reward During Preadolescence

The Impact of Psychiatric Comorbidities on Readmissions for Diabetes in Youth

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