The clinical presentation of children with tumours affecting the anterior visual pathways

Suharwardy, J; Elston, John

doi:10.1038/eye.1997.215

Cited by 29 publications

(39 citation statements)

References 8 publications

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“…A prolonged symptom interval is associated with an increased risk of life-threatening and disabling neurological complications at presentation and a worse cognitive outcome in survivors [3,4,6,21,26,29]. It has a detrimental effect upon professional relationships with families and the subsequent psychological well-being of the child and their family [7].…”

Section: Discussionmentioning

confidence: 99%

Progression from first symptom to diagnosis in childhood brain tumours

et al. 2011

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This study was undertaken to investigate the evolution of clinical features between onset of symptoms and diagnosis in children with brain tumours and to identify ways of shortening the time to diagnosis. One hundred and thirty-nine children with a brain tumour were recruited from four UK paediatric neuro-oncology centres. Children had a median of one symptom or sign at symptom onset and six by diagnosis. The symptoms and/or signs experienced at symptom onset and at diagnosis were as follows: headache in 55 and 81 children, nausea and vomiting in 39 and 88 children, motor system abnormalities in 31 and 93 children, cranial nerve palsies in 24 and 75 children, visual system abnormalities in 23 and 96 children, endocrine or growth abnormalities in 10 and 35 children and behavioural change in 4 and 55 children. The median time between symptom onset and diagnosis (symptom interval) was 3.3 months. A longer symptom interval was associated with head tilt, cranial nerve palsies, endocrine and growth abnormalities and reduced visual acuity. More than half of children with brain tumours developed problems with vision and more than a third developed motor problems, cranial nerve palsies, behavioural change, or nausea and vomiting between symptom onset and diagnosis.

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Section: Discussionmentioning

confidence: 99%

Progression from first symptom to diagnosis in childhood brain tumours

et al. 2011

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“…Two recent UK cohorts of children with brain tumours had median symptom intervals (time between symptom onset and diagnosis) of 2.5 and 3.5 months,13 14 up to three times longer than that experienced by children in North America, Poland, Israel and Switzerland 15–19. Children with brain tumours who experience a long symptom interval are more likely than those who are diagnosed rapidly to present with life threatening complications, have frequently developed irreversible neurological deficits by diagnosis (particularly visual loss and endocrinopathies) and show greater cognitive deficits in later life 20–25. A prolonged time to diagnosis undermines the trust patients and their families have in the UK healthcare system and often leads to significant psychological distress 26…”

Section: Introductionmentioning

confidence: 99%

The diagnosis of brain tumours in children: a guideline to assist healthcare professionals in the assessment of children who may have a brain tumour

Wilne

Koller

Collier

et al. 2010

Archives of Disease in Childhood

111

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“…In a series of 200 children with brain tumours, Wilne et al [1] reported that 10% presented complaining of visual difficulties and 38% had papilloedema. Suharwardy et al [2], in a retrospective study of 17 children with tumours affecting the visual pathways, found that children with progressive visual deterioration due to tumours do not readily verbalise their difficulty and may have profound visual loss at presentation. Ferrante et al [3] in a review of 208 cases of paediatric intracranial meningiomas reported a 12.1% incidence of visual loss.…”

Section: Discussionmentioning

confidence: 98%