The clinical ramifications of polycystic ovarian morphology in oocyte donors

Cho, M.; Ambartsumyan, G.; Danzer, H.; Brennan, Kathleen; Surrey, M.

doi:10.1007/s10815-012-9924-6

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Cho et al compared 113 women with apparently normal ovaries to 36 women with isolated polycystic ovarian morphology and found that, similar to cases of PCOS, women with polycystic ovarian morphology produced more oocytes and also exhibited increased sensitivity to gonadotropins; even so, the researchers found equivalent rates of fertility and pregnancy between the groups [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?

Vaz

Evangelista

Sartório³

et al. 2016

BioMed Research International

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Background. The use of donated oocytes for in vitro fertilization treatment in patients with ovarian failure is universally recognized. But would patients with polycystic ovarian syndrome (PCOS) be a good choice for egg donation programs? Objective. Comparing the pregnancy rates of egg receptors from donor patients diagnosed with PCOS to receptors from donors without PCOS. Design. Retrospective cohort study. Methods. A total of 234 patients who had undergone egg reception program were separated into two groups: Group I, receptors from PCOS donors (n = 36); Group II, receptors from donors without PCOS (n = 198). Medical records were reviewed and the fertilization, implantation, and pregnancy rates were calculated. Results. PCOS patients had an average of 3.23 more oocytes retrieved, but there were no differences in the number of mature oocytes that were used for donation between the groups. We also observed that the number of transferred embryos was also not significantly different, as well as the fertilization and implantation rates. The clinical pregnancy rates were not significantly different: 28% and 26% in Group I and Group II, respectively. Conclusions. Women with PCOS should not be excluded from egg donation programs.

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Section: Discussionmentioning

confidence: 99%

“…Another important concern is the impact on pregnancy rates when patients with PCOS donate their oocytes for IVF. The literature includes only a few studies that evaluate pregnancy rates and miscarriage risk among patients who have received oocytes from those with PCOS [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?

Vaz

Evangelista

Sartório³

et al. 2016

BioMed Research International

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“…Studies have shown that the change of oocyte competence (OC) may be linked to the low fertility of PCOS women, however, OC varies among PCOS phenotypes and associated morbidities (36,37). Other studies find that non-PCOS infertile individuals obtained oocyte donation from PCOS patients, and the rates of fertilization, implantation, and clinical pregnancy did not diminish, suggesting that the oocyte quality of PCOS patients might be normal (38)(39)(40). Compared with the non-PCOS population, PCOS patients who recovered ovulation with treatment had lower clinical pregnancy and live birth rates, suggesting that impaired endometrial receptivity was the one of factors leading to infertility in PCOS patients (41).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

et al. 2022

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ObjectiveWe aimed to study the relationship between ferroptosis proteins and reproductive outcomes of infertile patients with PCOS and construct the related prognostic model.MethodsThese endometrium samples of the study were collected from 33 women with PCOS and 7 control women with successful pregnancies at the Reproductive Center of Lanzhou University Second Hospital, September 2019 to September 2020. The 40 patients’ endometrium was identified the differentially expressed proteins (DEPs) using liquid chromatography tandem mass spectrometry. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Gene Ontology (GO) showed that the DEPs related pathways and functions between PCOS and controls. Subsequently, univariate Cox regression analysis and Lasso regression were used to identifying independent prognostic ferroptosis proteins, which were utilized to establish a prognostic model. Then the performance of the prognostic model was evaluated by receiver operating characteristic curve (ROC) and decision curve analysis (DCA). Then clinical data and prognostic model were used to predict the reproductive outcomes of PCOS patients by constructing the nomograms. Finally, we performed the single sample gene set enrichment analysis (ssGSEA) to explore the correlation between risk scores and immune status.ResultsA total of 5331 proteins were identified, 391 proteins were differentially expressed in the PCOS and controls. The KEGG analysis revealed that the ferroptosis pathway was significantly different between PCOS and controls. 5 ferroptosis proteins (GPX4, DPP4, G6PD, PCBP1, and PCBP2) prognostic model (FerSig) was constructed via Cox regression and Lasso regression. Patients were separated into high and low-risk groups according to the FerSig. Kaplan-Meier curve showed that patients in the low-risk group had much better reproductive outcomes than those in the high-risk group. The DCA showed that the risk score was an independent predictive factor for reproductive outcomes. Compared with clinical data, ROC curve analysis indicated the FerSig proteins as a potential diagnostic and prognostic factor in PCOS patients. Functional analysis revealed that the FerSig proteins and immune microenvironment were correlated to the prognosis of PCOS.ConclusionThe prognostic model focused on the FerSig proteins could predict the reproductive outcomes of PCOS patients with decreased endometrial receptivity, and provided theoretical basis for individualized treatment.

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“…Oocytes from donors with PCOS demonstrated similar fertilization, clinical pregnancy, implantation, and miscarriage rates as oocytes from normal-appearing ovaries [ 5 ]. DO with polycystic ovarian morphology has equivalent pregnancy rates and does not need to be excluded as a potential donors [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…PCOS may increase the risk of adverse perinatal outcomes and the long-term health of the offspring [ 4 ]. However, few studies have assessed pregnancy outcomes in patients with PCOS receiving oocytes [ 5 , 6 ]. Vaz GQ et al showed that PCOS in donors does not seem to affect pregnancy and implantation rates [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

Jiang

Yuan

Song

et al. 2022

BMC Pregnancy Childbirth

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Background The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and offspring follow-up in patients with PCOS as the recipients are unclear. This study was to compare the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor. Methods This was a retrospective cohort study of 62 patients undergoing the oocyte reception program were separated into 2 groups: Group I, PCOS oocyte recipients (n = 30); Group II, non-PCOS recipients (n = 32). Medical records were reviewed, and rates of fertilization, cleavage, high-quality embryos and blastocysts were compared between PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancies, and offspring outcomes were calculated using the first single vitrified-warmed blastocyst transfer (SVBT) analysis between the groups. Results The average recipient age and body mass index (BMI) of PCOS and non-PCOS patients was (36.3 ± 2.6 vs. 36.2 ± 2.8, and 23.4 ± 3.9 vs. 23.7 ± 4.0), respectively (P > 0.05). The fertilization, cleavage, high-quality embryos and blastocyst rates were not significantly different between the PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancies were not significantly different in SVBT between the PCOS and non-PCOS groups. The incidence of complications, such as pre-eclampsia or gestational diabetes, between PCOS and non-PCOS groups was similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm births were also similar (11.8% vs.16.7%, P > 0.05). Donor oocytes are more likely to be delivered via cesarean Sect. (80.0% vs. 86.7%: P > 0.05). The mean gestational age, birth weight, and height were comparable between the 2 groups during full-term delivery. Conclusion There was no difference in the pregnancy outcomes and follow-up of the offspring between the PCOS and non-PCOS groups.

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The clinical ramifications of polycystic ovarian morphology in oocyte donors

Cited by 4 publications

References 23 publications

Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?

Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

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