The clinical relationship between cognitive impairment and psychosocial functioning in major depressive disorder: A systematic review

Cambridge, Olivia R.; Knight, Matthew J.; Mills, Natalie; Baune, Bernhard T.

doi:10.1016/j.psychres.2018.08.033

Cited by 130 publications

(97 citation statements)

References 53 publications

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“…Synthesis of social cognitive information requires coordination of several cognitive systems, including, visuospatial and verbal memory, as well as executive and attentional control (Baddeley, , 2002; Weightman et al., ). As a result, cold cognitive deficits in MDD may negatively interact with social cognitive issues (Baune et al., ; Cambridge, Knight, Mills, & Baune, ; Evans, Iverson, Yatham, & Lam, ; Knight & Baune, ; McIntyre & Lee, ; Weightman et al., ). Support for this notion has been found in research in attention deficit hyperactivity disorder, bipolar, and schizophrenia (Anselmetti et al., ; Dhar, Been, Minderaa, & Althaus, ), with findings pointing to a negative effect of cognitive impairment (e.g., processing speed and executive functioning) on social abilities.…”

Section: Introductionmentioning

confidence: 99%

“…Current literature suggests that cold cognitive deficits contribute to psychosocial issues in MDD, independently of other symptoms (Cambridge et al., ; Evans et al., ; Knight & Baune, ; McIntyre & Lee, ). Specifically, relationships have been identified between several cold cognitive domains (i.e., executive, attention, and memory dysfunction) and issues in occupational functioning, interpersonal relationships, and self‐perceived quality of life (Caldirola et al., ; Evans et al., ; Kim et al., ; Knight & Baune, ; McIntyre et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, relationships have been identified between several cold cognitive domains (i.e., executive, attention, and memory dysfunction) and issues in occupational functioning, interpersonal relationships, and self‐perceived quality of life (Caldirola et al., ; Evans et al., ; Kim et al., ; Knight & Baune, ; McIntyre et al., ). Psychosocial issues associated with MDD often persist in symptomatically recovered (i.e., remitted) patients, and are associated with illness relapse (Bortolato, Carvalho, & McIntyre, ; Cambridge et al., ; Knight, Air, & Baune, ; Miller et al., ), highlighting a need for greater clinical understanding and improved treatment of issues underlying psychosocial dysfunction. As cold cognition interacts with and is a core component of social cognition, it is reasonable to predict that social cognitive issues could also contribute independently to functional deficits in MDD.…”

Section: Introductionmentioning

confidence: 99%

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Social cognitive abilities predict psychosocial dysfunction in major depressive disorder

Knight

Baune

2018

Depress Anxiety

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Social cognitive abilities predict psychosocial dysfunction in major depressive disorder

Knight

Baune

2018

Depress Anxiety

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“…The association between depression and cognitive dysfunctions has long been discussed in the scientific literature. In a recent review, Cambridge et al 16 have stated that impairments in specific (not all) depressive domains -quality of life, social, professional, social and global individual functioning, interpersonal relations -have a main role in cognitive impairment. Moreover, depression-associated cognitive impairments and even depression associated with cognitive impairments do not respond (or minimally respond) to antidepressant treatment, but to treatment targeted on cognition and social functioning 16,17 .…”

Section: Discussionmentioning

confidence: 99%

“…In a recent review, Cambridge et al 16 have stated that impairments in specific (not all) depressive domains -quality of life, social, professional, social and global individual functioning, interpersonal relations -have a main role in cognitive impairment. Moreover, depression-associated cognitive impairments and even depression associated with cognitive impairments do not respond (or minimally respond) to antidepressant treatment, but to treatment targeted on cognition and social functioning 16,17 . The influence of psychopathic personal traits on cognitive abilities is well described in the literature, though Carson 18 has suggested that mild and borderline psychopathic changes are associated with better performance in some cognitive tasks.…”

Section: Discussionmentioning

confidence: 99%

Do personal traits moderate cognitive abilities in diabetes mellitus?

Valkova¹,

Veleva²,

Burgov³

2019

Arch Balk Med Union

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Est-ce qu'il y a une influence des traits personnels sur les habilités cognitives en cas de diabète sucré ? Introduction. La relation entre le fonctionnement cognitif et les traits de personnalité est une question d'intérêt et de débat. Le diabète est associé à des changements cognitifs et de la personnalité. Le but de notre étude était de découvrir les interrelations entre les fonctions cognitives et les traits de personnalité des patients atteints de diabète. Matériels et méthodes. Nous avons examiné 115 patients atteints de diabète (âge moyen 62,47 ± 10,60, 49 hommes, 66 femmes), dont 13 personnes atteintes de diabète de type 1 et 102 atteintes de diabète de type 2 admis , pendant la période 2016-2017, à la Clinique

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Cognitive Function in People With Familial Risk of Depression

et al. 2023

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ImportanceCognitive impairment in depression is poorly understood. Family history of depression is a potentially useful risk marker for cognitive impairment, facilitating early identification and targeted intervention in those at highest risk, even if they do not themselves have depression. Several research cohorts have emerged recently that enable findings to be compared according to varying depths of family history phenotyping, in some cases also with genetic data, across the life span.ObjectiveTo investigate associations between familial risk of depression and cognitive performance in 4 independent cohorts with varied depth of assessment, using both family history and genetic risk measures.Design, Setting, and ParticipantsThis study used data from the Three Generations at High and Low Risk of Depression Followed Longitudinally (TGS) family study (data collected from 1982 to 2015) and 3 large population cohorts, including the Adolescent Brain Cognitive Development (ABCD) study (data collected from 2016 to 2021), National Longitudinal Study of Adolescent to Adult Health (Add Health; data collected from 1994 to 2018), and UK Biobank (data collected from 2006 to 2022). Children and adults with or without familial risk of depression were included. Cross-sectional analyses were conducted from March to June 2022.ExposuresFamily history (across 1 or 2 prior generations) and polygenic risk of depression.Main Outcomes and MeasuresNeurocognitive tests at follow-up. Regression models were adjusted for confounders and corrected for multiple comparisons.ResultsA total of 57 308 participants were studied, including 87 from TGS (42 [48%] female; mean [SD] age, 19.7 [6.6] years), 10 258 from ABCD (4899 [48%] female; mean [SD] age, 12.0 [0.7] years), 1064 from Add Health (584 [49%] female; mean [SD] age, 37.8 [1.9] years), and 45 899 from UK Biobank (23 605 [51%] female; mean [SD] age, 64.0 [7.7] years). In the younger cohorts (TGS, ABCD, and Add Health), family history of depression was primarily associated with lower performance in the memory domain, and there were indications that this may be partly associated with educational and socioeconomic factors. In the older UK Biobank cohort, there were associations with processing speed, attention, and executive function, with little evidence of education or socioeconomic influences. These associations were evident even in participants who had never been depressed themselves. Effect sizes between familial risk of depression and neurocognitive test performance were largest in TGS; the largest standardized mean differences in primary analyses were −0.55 (95% CI, −1.49 to 0.38) in TGS, −0.09 (95% CI, −0.15 to −0.03) in ABCD, −0.16 (95% CI, −0.31 to −0.01) in Add Health, and −0.10 (95% CI, −0.13 to −0.06) in UK Biobank. Results were generally similar in the polygenic risk score analyses. In UK Biobank, several tasks showed statistically significant associations in the polygenic risk score analysis that were not evident in the family history models.Conclusions and RelevanceIn this study, whether assessed by family history or genetic data, depression in prior generations was associated with lower cognitive performance in offspring. There are opportunities to generate hypotheses about how this arises through genetic and environmental determinants, moderators of brain development and brain aging, and potentially modifiable social and lifestyle factors across the life span.

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The clinical relationship between cognitive impairment and psychosocial functioning in major depressive disorder: A systematic review

Cited by 130 publications

References 53 publications

Social cognitive abilities predict psychosocial dysfunction in major depressive disorder

Social cognitive abilities predict psychosocial dysfunction in major depressive disorder

Do personal traits moderate cognitive abilities in diabetes mellitus?

Cognitive Function in People With Familial Risk of Depression

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