The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma

Abstract

ObjectiveThe correlation of depleted blood through midline shift in acute subdural hematoma remains the most reliable clinical predictor to date. On the other hand, patient’s ABO blood type has a profound impact on coagulation and hemostasis. We conducted this study to evaluate the role of patient’s blood type in terms of incidence, clinical course and outcome after acute subdural hematoma bleeding.Methods100 patients with acute subdural hematoma treated between 2010 and 2015 at the author’s institution were included. Baseline characteristics and clinical findings including Glasgow coma scale, Glasgow outcome scale, hematoma volume, rebleeding, midline shift, postoperative seizures and the presence of anticoagulation were analyzed for their association with ABO blood type.ResultsPatient’s with blood type O were found to have a lower midline shift (p<0.01) and significantly less seizures (OR: 0.43; p<0.05) compared to non-O patients. Furthermore, patients with blood type A had the a significantly higher midline shift (p<0.05) and a significantly increased risk for postoperative seizures (OR: 4.01; p<0.001). There was no difference in ABO blood type distribution between acute subdural hematoma patients and the average population.ConclusionThe ABO blood type has significant influence on acute subdural hematoma sequelae. Patient’s with blood type O benefit in their clinical course after acute subdural hematoma whereas blood type A patients are at highest risk for increased midline shift and postoperative seizures. Further studies elucidating the biological mechanisms of blood type depended hemostaseology and its role in acute subdural hematoma are required for the development of an appropriate intervention.

Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese

“…Since the ABO blood groups are suspected to be associated with various health conditions 32 , 33 , we analyzed the association between predicted ABO blood groups and self-reported clinical phenotypes in the TWB cohort. We found that blood type O was less likely to be associated with epilepsy, consistent with the findings of a previous study 34 , and that TWB participants with blood type AB had a significantly higher incidence rate of epilepsy compared to type O participants (OR = 1.84, 95% CI ~1.2–2.8).…”

Role of ABO blood type in delayed cerebral ischemia onset and clinical outcomes after aneurysmal subarachnoid hemorrhage in an ethnic minority urban population

“…Although some studies have shown that peripheral vasospasm is related to increase levels of VIII factor, [6,23,24] this evidence may not be necessary transposable to cerebrovascular conditions after aSAH. Furthermore, the amount of bleeding and presumably, a faster clot liquidation [3] in "O" type patients can propitiate an environment within the subarachnoid space in which abnormal high levels of hemoglobin and oxidized heme products can intercept with high affinity free NO [14] and synthetize endogenous eNOS [22] inhibitors, leading to dysregulation of vascular tone and therefore, DCI onset.…”

The influence of ABO blood group on mortality in major trauma

“…Recently, a study investigated the influence of ABO blood group on outcome subdural hematoma. 7 Patients with blood type O that were found to have a decreased midline shift, a lower postoperative epileptic seizure incidence. In terms of rebleeding rate no significant difference between O and non-O patients were found (OR 0.65; 95% CI [0.23-1.82]; P=0.291) and morbidity outcome, expressed through the GOS (Glasgow Outcome Scale) at 3 months, showed no significant difference between O and non-O patients either (P=0.504 mean GOS 3).…”