The clinical relevance of OSM in inflammatory diseases: a comprehensive review

Wolf, Cody L.; Pruett, Clyde; Lighter, Darren; Jorcyk, Cheryl L.

doi:10.3389/fimmu.2023.1239732

Cited by 13 publications

(1 citation statement)

References 258 publications

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“…It is a pleiotropic factor that participates in several organismic processes including hematopoiesis, differentiation, regeneration, and inflammation. On the other hand, several pathological processes including arthritis, ossification, dermatitis, fibrosis, gingivitis, and carcinogenesis are found to have OSM mediation[ 11 ]. In colorectal cancer, higher OSM levels are associated with advanced disease and metastasis[ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

Yang,

Fu,

Pan

2024

World J Gastrointest Surg

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BACKGROUND Oncostatin M (OSM) is a pleiotropic cytokine which is implicated in the pathogenesis of inflammatory bowel disease (IBD). AIM To evaluate the prognostic role of OSM in IBD patients. METHODS Literature search was conducted in electronic databases (Google Scholar, Embase, PubMed, Science Direct, Springer, and Wiley). Studies were selected if they reported prognostic information about OSM in IBD patients. Outcome data were synthesized, and meta-analyses were performed to estimate standardized mean differences (SMDs) in OSM levels between treatment responders and non-responders and to seek overall correlations of OSM with other inflammatory biomarkers. RESULTS Sixteen studies (818 Crohn’s disease and 686 ulcerative colitis patients treated with anti-tumor necrosis factor-based therapies) were included. OSM levels were associated with IBD severity. A meta-analysis found significantly higher OSM levels in non-responders than in responders to therapy [SMD 0.80 (0.33, 1.27); P = 0.001], in non-remitters than in remitters [SMD 0.75 (95%CI: 0.35 to 1.16); P < 0.0001] and in patients with no mucosal healing than in those with mucosal healing [SMD 0.63 (0.30, 0.95); P < 0.0001]. Area under receiver operator curve values showed considerable variability between studies but in general higher OSM levels were associated with poor prognosis. OSM had significant correlations with Simple Endoscopic Score of Crohn’s disease [r = 0.47 (95%CI: 0.25 to 0.64); P < 0.0001], Mayo Endoscopic Score [r = 0.35 (95%CI: 0.28 to 0.41); P < 0.0001], fecal calprotectin [r = 0.19 (95%CI: 0.08 to 0.3); P = 0.001], C-reactive protein [r = 0.25 (95%CI: 0.11 to 0.39); P < 0.0001], and platelet count [r = 0.28 (95%CI: 0.17 to 0.39); P < 0.0001]. CONCLUSION OSM is a potential candidate for determining the severity of disease and predicting the outcomes of anti-tumor necrosis factor-based therapies in IBD patients.

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Section: Introductionmentioning

confidence: 99%

Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

Yang,

Fu,

Pan

2024

World J Gastrointest Surg

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Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis‐associated acute kidney injury

Wei,

Sun,

et al. 2024

Journal of Periodontology

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BackgroundAcute kidney injury (AKI) is characterized by rapid renal decline. Periodontitis, a chronic oral inflammatory disease, is increasingly associated with renal dysfunction. Although periodontitis is recognized as a contributor to kidney damage, the mechanisms linking it to AKI remain unclear.MethodsThis study explored the effects of Porphyromonas gingivalis (P. gingivalis) W83‐infected periodontitis on AKI in C57BL/6J mice, using ischemia‐reperfusion injury 55 days post‐infection. Gingipain inhibitors, KYT‐1 and KYT‐36, were applied. Detection of P. gingivalis was performed using quantitative real‐time polymerase chain reaction (qRT‐PCR) and PCR, while transcriptome sequencing, qRT‐PCR, immunohistochemistry, and immunofluorescence staining assessed renal damage. In vitro, HK‐2 cells were exposed to P. gingivalis at a multiplicity of infection of 10 for 48 h, with inhibition by gingipain or oncostatin M (OSM). Disruption of tight junctions (TJs) was quantified using qRT‐PCR, transepithelial electrical resistance, and cell counting kit‐8 assays.ResultsPeriodontitis worsened AKI, linked to P. gingivalis infection and renal TJ disruption in the kidney. P. gingivalis infection activated OSM expression, which correlated positively with gingipain. Significantly, OSM and gingipain might collaboratively contribute to the damage of renal TJs, with the reduced expression of TJ proteins. Suppressing gingipain activity presented itself as a protective strategy against the destruction of TJs and the attendant worsening of AKI due to periodontitis.ConclusionsOur study enhances the understanding of the interplay between periodontitis and AKI, highlighting the harmful impact of P. gingivalis in AKI.

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Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis

Ye,

Chen,

Cheng

et al. 2025

International Immunopharmacology

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The clinical relevance of OSM in inflammatory diseases: a comprehensive review

Cited by 13 publications

References 258 publications

Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis‐associated acute kidney injury

Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis

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