The Clinical Relevance of Pain Severity Changes: Is There Any Difference Between Asian and Caucasian Patients With Osteoarthritis Pain?

Abstract

The objective of the present analysis was to determine whether changes in Brief Pain Inventory (BPI) average pain scores by patient global impression of improvement (PGI‐I) category and the cut‐off for clinically important difference (CID) were different between Asian and Caucasian patients with chronic pain due to osteoarthritis. This analysis used data from 3 (Caucasian) and 2 (Asian) randomized, placebo‐controlled, 10‐ to 14‐week duloxetine studies for the treatment of patients ≥40 years of age with osteoarthritis pain. The receiver operating characteristic (ROC) analysis was used to characterize the association between changes in BPI average pain scores and PGI‐I levels at study endpoint. The CID was characterized by PGI‐I, and the cut‐off point for CID in BPI average pain scores was determined by the intersection of a 45‐degree tangent line with each ROC curve. Data from 668 Asian and 868 Caucasian patients were available for analysis. Baseline BPI average pain ratings including worst and least pain were comparable between Asians and Caucasians. Ratings for percentage change from baseline to endpoint for BPI average pain scores in Asian patients and Caucasian patients were similar across the 7 PGI‐I categories, regardless of age, gender, study, and treatment. The ROC analysis results of cut‐off points in BPI average pain scores demonstrated the raw change cut‐off was −3.0, and percentage change cut‐off was −40% for both Asian and Caucasian patients. Overall, the present analysis concludes changes in BPI average pain scores by PGI‐I category and the cut‐off for CID were similar for Asian and Caucasian patients with chronic pain due to osteoarthritis.

Impact of Racial/Ethnic Disparities on Patient-Reported Outcomes Following Cervical Spine Surgery

“…that found similar disability and quality of life scores between East Asian and White patients at 24 months after cervical spine surgery for degenerative cervical myelopathy. Studies in the chronic pain literature also support our findings by demonstrating that Asian Americans report low pain prevalence and have similar pain scores when compared with White patients 44,50 . The literature suggests that similarities in outcomes may be due to the high rates of education and family income found in Asian individuals, which result in better access to specialty care 44 .…”

“…Studies in the chronic pain literature also support our findings by demonstrating that Asian Americans report low pain prevalence and have similar pain scores when compared with White patients. 44,50 The literature suggests that similarities in outcomes may be due to the high rates of education and family income found in Asian individuals, which result in better access to specialty care. 44 However, the majority of studies, including ours, have a small sample of Asian individuals.…”

Ultrasound Guided Pes Anserine Bursitis Injection Choices; Prolotherapy or Oxygen-Ozone or Corticosteroid: A Randomized Multicenter Clinical Trial

“…The Patient Global Impression of Improvement (PGI-I) is a global, immediate, and simple index that might be used to rate the response to treatment. The PGI-I is a question asking the patient to rate the condition of the knee compared with the condition before the intervention on a scale from 1 (very much better) to 7 (very much worse) 22 …”

“…The PGI-I is a question asking the patient to rate the condition of the knee compared with the condition before the intervention on a scale from 1 (very much better) to 7 (very much worse). 22…”

Efficacy and Safety of Pregabalin Prolonged Release–Etoricoxib Combination Compared to Etoricoxib for Chronic Low Back Pain: Phase 3, Randomized Study

“…Patient Global Impression of Improvement As the name suggests, PGI-I is a global index used to rate the patients' impression of their condition's response to a particular therapy [15]. The assessment is based on the following ratings: 1 = very much better, 2 = much better, 3 = a little better, 4 = no change, 5 = a little worse, 6 = much worse, 7 = very much worse.…”