The clinical relevance of sexual dysfunction in systemic sclerosis

Bruni, Cosimo; Raja, Jasmin; Denton, Christopher P.; Matucci‐Cerinic, Marco

doi:10.1016/j.autrev.2015.07.016

Cited by 27 publications

(23 citation statements)

References 55 publications

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“…Main features of SSc are indicated in Table 1, according to clinico-biological phenotypes of the disease. Besides these specific symptoms, SSc is associated with a high frequency of fatigue, depression, sleeping disorders and sexual dysfunction that also lead to disability and a reduced quality of life [1,3].…”

Section: Clinical Featuresmentioning

confidence: 99%

Systemic sclerosis: An update in 2016

Desbois

Cacoub

2016

Autoimmunity Reviews

134

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Systemic sclerosis (SSc) is a chronic immune disorder of unknown origin, dominated by excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular endothelial dysfunction at the origin of skin ischemia, renal and pulmonary artery lesions. Renal and pulmonary complications are mainly responsible for the severity of the disease. Recent advances led to a better understanding of pathological mechanisms and a more accurate classification of patients according to clinical and biological (auto-antibodies) phenotype. Recent trials provided interesting data on different therapeutic strategies, depending on organ involvement. These data are of particular importance in such disease, still characterized by increased mortality and morbidity rates. In this review, we aim to synthetize recent advances in diagnosis and prognosis leading to better classification of SSc patients, and in therapeutic management.

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Section: Clinical Featuresmentioning

confidence: 99%

Systemic sclerosis: An update in 2016

Desbois

Cacoub

2016

Autoimmunity Reviews

134

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“…Moreover, the changes in physical appearance may have emotional effects and influence interpersonal relationships [13,14]. Indeed, as a multisystem disease, SSc can affect various organs and is associated with cardio-pulmonary and musculo-skeletal involvements, which limit the exercise capacity.…”

Section: Sexuality and Fertility Of Women With Sscmentioning

confidence: 99%

Special considerations in pregnant systemic sclerosis patients

Sobanski

Launay

Depret

et al. 2016

Expert Review of Clinical Immunology

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Evaluating the fertility and pregnancy outcomes in systemic sclerosis (SSc) women is challenging. Studies are still limited or subject to potential methodological biases. Areas covered: This work is a comprehensive review of the literature. We discuss the potential impact of SSc on women's pregnancy outcomes and the effects of pregnancy on SSc. We summarize the physiological changes during pregnancy and describe our experience. Expert commentary: Although the miscarriage rate does not appear increased in SSc, women are exposed to a higher risk of premature birth and intrauterine growth restriction compared with the general population. Early diffuse cutaneous SSc and use of corticosteroids are risk factors, whereas folic acid use prevents against premature birth. All SSc women wishing to conceive should be counselled during a preconception visit. Physiological changes arising during pregnancy may be the source of clinical problems in SSc women with organs with limited capacities.

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“…The consequence of skin thickening and other physical changes is the impaired body image, self-esteem, and sexuality. However, it has been also reported that body image dissatisfaction does not correlate with reduced sexual function [30]. In a different study, the major reasons for decreased sexual activity in married women with SSc were fatigue, altered body image, and pain [2].…”

Section: Sexual Functioning In Women With Systemic Sclerosismentioning

confidence: 94%

“…If skin tightening causes the mouth to shrink, kissing or oral sex could become difficult. Sometimes the skin become stiffer around the vaginal introitus, which often leads to painful penetration, and changes in the vaginal mucosae causing lubrication disorder contribute to this [27,29,30]. Specifically, 56% of SSc female patients reported painful penetration during the intercourse [31].…”

Section: Sexual Functioning In Women With Systemic Sclerosismentioning

confidence: 99%

Sexual Dysfunction in Patients with Systemic Sclerosis

Heřmánková¹

2019

New Insights Into Systemic Sclerosis [Working Title]

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Systemic sclerosis (SSc) may affect all aspects of life including sexual function. Although sexual dysfunction is a neglected area of quality of life in patients with SSc, it turns out that it is an important issue for both men and women characterized by high prevalence. The etiology of sexual dysfunction in systemic sclerosis is multifactorial and includes factors associated with both physical and emotional (psychological) status. The most common physical problems in women are vaginal dryness, dyspareunia, and vaginal tightness. Erectile dysfunction is not only a frequent but also often underestimated clinical symptom in men with SSc. The incidence of erectile dysfunction in patients with SSc ranged from 12 to 81% in different studies. The main psychological factors that may affect sexuality are depression, fear, and changes in the appearance of the face and body that usually leads to impaired self-esteem. This chapter is a review about the impact of systemic sclerosis on sexual functioning.

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The clinical relevance of sexual dysfunction in systemic sclerosis

Cited by 27 publications

References 55 publications

Systemic sclerosis: An update in 2016

Systemic sclerosis: An update in 2016

Special considerations in pregnant systemic sclerosis patients

Sexual Dysfunction in Patients with Systemic Sclerosis

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