The clinical significance of a second transurethral resection for T1 high-grade bladder cancer: Results of a prospective study

Shim, Ji Sung; Choi, Hoon; Noh, Tae Il; Tae, Jong Hyun; Yoon, Sung Goo; Kang, Seok Ho; Bae, Jae Hyun; Park, Hong Seok; Park, Jae Young

doi:10.4111/kju.2015.56.6.429

Cited by 14 publications

(7 citation statements)

References 24 publications

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“…In our understanding, this is the most important casuistic published from re-TURBT in Brazil and comparable to many other studies in literature [21][22][23].…”

Section: Severalsupporting

confidence: 55%

Multicenter Analysis of the Oncological Positivity on Restaging Resection (Re-Turbt) of Urothelial Non-Muscle-Invasive Bladder Cancer

Ferreira¹,

Matheus²,

Neto³

et al. 2017

ARC Journal of Urology

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Objectives: The main objective was to determine the oncological positivity on restaging TURBT (re-TURBT), in patients submitted to a first complete transurethral resection of bladder tumor (TURBT). Moreover, to verify the most important site of tumor recurrence and changes in the treatment initially proposed. Methods: We retrospectively reviewed the records of patients who underwent a re-TURBT for urothelial nonmuscle-invasive bladder cancer (NMIBC) between

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“…In our understanding, this is the most important casuistic published from re-TURBT in Brazil and comparable to many other studies in literature [21][22][23].…”

Section: Severalsupporting

confidence: 55%

Multicenter Analysis of the Oncological Positivity on Restaging Resection (Re-Turbt) of Urothelial Non-Muscle-Invasive Bladder Cancer

Ferreira¹,

Matheus²,

Neto³

et al. 2017

ARC Journal of Urology

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“…The fact that local tumor control and accurate tumor staging depend on a complete TUR and reevaluation of the tumor base suggests that a restaging TURBT may be of value in assessing patients with bladder tumors [ 21 , 22 ]. Re-TURBT reduces the uncertainty of the depth of tumor invasion, better controls the primary tumor, and provides additional pathologic information that may help to select appropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

Pathology in repeated transurethral resection of a bladder tumor as a risk factor for prognosis of high-risk non-muscle-invasive bladder cancer

et al. 2017

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The prognostic value of repeat transurethral resection of bladder tumor (TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder cancer (NMIBC) was investigated. We retrospectively reviewed the medical records of patients treated from October 2004 to December 2013 at Seoul National University who underwent repeated TURBT within 2–6 weeks after an initial resection. The study enrolled patients who had been diagnosed with NMIBC at both the initial and repeat TURBT; patients with muscle-invasive tumors on repeat TURBT were excluded. We used stepwise multivariate Cox regression models stratified by study to assess the independent effects of the predictive factors and estimated hazard ratios (HRs) from the Cox models. We investigated a total of 198 patients who were diagnosed with high-risk NMIBC. In logistic regression analyses, number of bladder tumors (2–7: OR, 2.319; 8≤: OR, 3.353; p<0.05), initially high tumor grade (OR, 2.435; p = 0.040), and presence of carcinoma in situ lesion (OR, 3.639; p = 0.017) correlated with residual tumor in the repeated-TURBT specimen. T1 stage in repeated-TURBT significantly correlated with recurrence (HR, 1.837; p = 0.010) and progression (HR, 2.806; p = 0.029) in multivariate analysis. The high grades of tumors in repeated-TURBT also significantly correlated with progression but not recurrence in the multivariate analysis (HR 2.152; p = 0.008). In this study, the pathologic findings in repeated-TURBT correlated with recurrence and progression in high-risk NMIBC. Repeated-TURBT is valuable because it can predict the recurrence and progression of high-risk NMIBC in addition to obtaining accurate pathologic findings.

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“…This may be due to aggressive tumor biology. In a similar study by Shim et al .,[ 11 ] 29 patients with T1 high grade disease underwent restage TURBT and 22 of these were found to have residual tumor. There were total of 9 recurrences during followup after restage TURBT, 7 of which were in the group that had residual tumor at restage.…”

Section: Discussionmentioning

confidence: 99%

Utility of restage transurethral resection of bladder tumor

et al. 2018

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Introduction:Transurethral resection of bladder tumor (TURBT) aims at complete resection of all the visible tumors. Existing guidelines recommend restage TURBT in all patients with T1 and high-grade tumors, to avoid under-staging. However, restage TURBT may not be plausible/feasible at all the times. This study was performed with an aim to better define the utility of restage TURBT in a tertiary care hospital of India.Methods:Patients with high grade/T1 tumors at the first TURBT were prospectively enrolled. Their demographic profile, previous cystoscopic findings, and histological reports were recorded. The primary objective was to assess the tumor detection and stage up-migration rates at restage TURBT. The secondary objectives was to identify factors predicting presence of tumor at restage TURBT. Patients were followed up to detect recurrence and progression for a minimum of 3 months.Results:Of 128 prospective patients’ enrolled, 29 patients were lost to follow-up and 11 patients did not undergo restage. A total of eighty-eight patients underwent restage TURBT of which twenty-eight patients (31.8%) had tumor at their second TURBT with five of these patients being upstaged to T2. The risk of having a tumor at restage was significantly higher in patients with solid tumors (56.2% vs. 26.4%, P = 0.02, 95% confidence interval: 0.035–0.024) but was independent of the tumor size (P = 0.472), number of growths (P = 0.267), grade of tumor (P = 0.441), presence or absence of muscle at the initial TURBT (P = 0.371) and place of initial TURBT (P = 0.289). There was a significant difference in the recurrence and progression rates in patients who had tumor at restage as compared to those who did not (recurrence; 33.3% and 23.8%, P = 0.022, respectively vs. progression; 11.1% and 3.7% respectively, P = 0.07; mean follow-up = 10.8 months).Conclusions:We conclude that restage TURBT is necessary in patients with solid looking tumors and the presence of tumor at restage confers a higher risk of recurrence and progression.

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The clinical significance of a second transurethral resection for T1 high-grade bladder cancer: Results of a prospective study

Cited by 14 publications

References 24 publications

Multicenter Analysis of the Oncological Positivity on Restaging Resection (Re-Turbt) of Urothelial Non-Muscle-Invasive Bladder Cancer

Multicenter Analysis of the Oncological Positivity on Restaging Resection (Re-Turbt) of Urothelial Non-Muscle-Invasive Bladder Cancer

Pathology in repeated transurethral resection of a bladder tumor as a risk factor for prognosis of high-risk non-muscle-invasive bladder cancer

Utility of restage transurethral resection of bladder tumor

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