The clinical significance of allergen-specific IgG4 in allergic diseases

Lu, Qin; Tang, Lanfang; Liu, Cheng; Wang, Huiying

doi:10.3389/fimmu.2022.1032909

Cited by 22 publications

(10 citation statements)

References 98 publications

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“…As previously mentioned, the effectiveness of allergen‐specific immunotherapy (AIT) was evaluated by a reduction in circulating IgE levels and an increase in IgG4 expression in peripheral blood. Our research corroborated these findings at the transcriptional level 7,11,20 . Our study delineated the intricate landscape of immune cell populations during ICLIT, highlighting alterations in IGHE , IGHA , and IGHGs within memory B cell subsets.…”

Section: Discussionsupporting

confidence: 84%

“…Our research corroborated these findings at the transcriptional level. 7,11,20 Our study delineated the intricate landscape of immune cell populations during ICLIT, highlighting alterations in IGHE, IGHA, and IGHGs within memory B cell subsets. The rise of allergen-specific IgG2 and IgG4 through the intermediate allergen-specific IgG1+ memory B cells required CSR.…”

Section: Our Approach To Categorizing B Cells Into Functional Populat...mentioning

confidence: 85%

“…The ICLIT has been demonstrated as a novel, effective treatment through the evaluation of clinical outcomes and total quality of life score with an advantage in efficacy, safety, and patient adherence 15 . Even though the underlying molecular mechanism of AIT has not been fully illustrated, the perspective from immunologists insisted that the induction of immunological tolerance to allergens regulated by allergen‐specific IgE and protective IgG4 as well as IgA play a crucial role in the procedure of AIT 7,11,20 . We herein investigated the primary B cell populations in peripheral blood from an AR patient who underwent ICLIT, using scRNA‐seq to unveil the AIT‐related phenotype with the transcriptome.…”

Section: Discussionmentioning

confidence: 99%

“…15 Even though the underlying molecular mechanism of AIT has not been fully illustrated, the perspective from immunologists insisted that the induction of immunological tolerance to allergens regulated by allergen-specific IgE and protective IgG4 as well as IgA play a crucial role in the procedure of AIT. 7,11,20 We herein investigated the primary B cell populations in peripheral blood from an AR patient who underwent ICLIT, using scRNA-seq to unveil the AIT-related phenotype with the transcriptome. based on the antigen-binding affinity.…”

Section: Discussionmentioning

confidence: 99%

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Single‐cell RNA sequencing reveals the landscape of biomarker in allergic rhinitis patient undergoing intracervical lymphatic immunotherapy and related pan‐cancer analysis

Li,

Huang

et al. 2024

Environmental Toxicology

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IntroductionAllergic rhinitis (AR) is one of the leading allergic diseases worldwide. Allergen immunotherapy (AIT) induces persistent specific allergen tolerance to achieve remission of the symptoms in AR patients. We creatively conducted the intra‐cervical lymphatic immunotherapy (ICLIT) for AR patients. However, the underlying molecular mechanism of immune cell response of AIT in AR remains elusive.MethodTo investigate the transcriptome profile in AR patients who underwent ICLIT, we comprehensively investigated the transcriptional changes in B cells from peripheral blood mononuclear cells of AR patient by single‐cell RNA sequencing. Immunoglobulins and relative key gene, which influences the B cell differentiation, was demonstrated. The biomarkers' association with different types of tumors was investigated.ResultsNaive B cells, germinal center B cells, activated memory B cells, and memory B cells constituted the B cells subsets. The expression of IGHE, IGHGs, IGHA, IGHD, and IGHM from memory B cells was validated. Pseudotime analysis further indicated the dynamic change from the expression of the immunoglobulins in the memory B cells, suggesting that ITGB1 may contribute to the differentiation procedure of memory B cells. The cell–cell communication among these immune cells demonstrated the significantly enhanced CD23, BTLA signaling after ICLIT in AR patient. ITGB1 was upregulated in 13 tumors and downregulated in six others. High ITGB1 expression was linked to poor prognosis in eight types of tumors. ITGB1 expression showed correlations with tumor mutation burden, tissue purity, and microsatellite instability in different types of tumors.DiscussionITGB1 was demonstrated as a potential biomarker for AR patients after ICLIT and is significant in identifying immune infiltration in tumor tissue and predicting tumor prognosis.

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Section: Discussionsupporting

confidence: 84%

Section: Our Approach To Categorizing B Cells Into Functional Populat...mentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Single‐cell RNA sequencing reveals the landscape of biomarker in allergic rhinitis patient undergoing intracervical lymphatic immunotherapy and related pan‐cancer analysis

Li,

Huang

et al. 2024

Environmental Toxicology

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“…IgA in mucosal secretions can bind to allergens, forming immune complexes that prevent the allergens from crossing the mucosal barrier and entering the circulation (immune exclusion). IgA can neutralize allergens' biological activity by binding to them and preventing them from inducing an immune response 57,58 …”

Section: Mechanisms Of the Most Important Allergic Diseasesmentioning

confidence: 99%

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

Jutel,

Agache,

Zemelka‐Wiacek

et al. 2023

Allergy

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The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies and patient access to extensive health care, has resulted in vast amounts of unbiased data enabling in‐depth disease characterization. New disease endotypes have been identified for various allergic diseases and triggered the gradual transition from a disease description focused on symptoms to identifying biomarkers and intricate pathogenetic and metabolic pathways. Consequently, the current disease taxonomy has to be revised for better categorization. This European Academy of Allergy and Clinical Immunology Position Paper responds to this challenge and provides a modern nomenclature for allergic diseases, which respects the earlier classifications back to the early 20th century. Hypersensitivity reactions originally described by Gell and Coombs have been extended into nine different types comprising antibody‐ (I‐III), cell‐mediated (IVa‐c), tissue‐driven mechanisms (V‐VI) and direct response to chemicals (VII). Types I‐III are linked to classical and newly described clinical conditions. Type IVa‐c are specified and detailed according to the current understanding of T1, T2 and T3 responses. Types V‐VI involve epithelial barrier defects and metabolic‐induced immune dysregulation, while direct cellular and inflammatory responses to chemicals are covered in type VII. It is notable that several combinations of mixed types may appear in the clinical setting. The clinical relevance of the current approach for allergy practice will be conferred in another article that will follow this year, aiming at showing the relevance in clinical practice where various endotypes can overlap and evolve over the lifetime.

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A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy

Wei,

Gao,

Tai

et al. 2024

The Kaohsiung J of Med Scie

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Allergic rhinitis (AR) is a widespread health issue with a rising global prevalence, and sublingual immunotherapy (SLIT) has shown efficacy in AR treatment. We examined specific immunoglobulin G4 (sIgG4) expression in AR and its role in evaluating SLIT efficacy and predicting patient prognosis. We compared total nasal symptom score (TNSS), total medication score (TMS), visual analogue scale (VAS) score, inflammatory cytokines, and immune function markers in AR patients before and after SLIT. SLIT reduced TNSS, TMS, VAS scores, IL‐4, IL‐17, eosinophilia percentage (EOS%), and specific immunoglobulin E (sIgE) levels, while increasing INF‐γ, IL‐10, and sIgG4. The sIgG4 level at pre‐treatment and 12 months post‐treatment was negatively correlated with TNSS, TMS, VAS score, IL‐4, IL‐17, EOS%, and sIgE, and positively correlated with IFN‐γ and IL‐10. Most patients showed symptomatic improvement. After 12 months, sIgG4 level demonstrated an area under the curve (AUC) of 0.867 for assessing SLIT as effective. Pre‐treatment sIgG4 level showed an AUC of 0.869 for predicting SLIT as effective. Collectively, sIgG4 has strong potential assessing SLIT efficacy and prognosis in AR patients, with correlations to TNSS, TMS, VAS score, and IL‐4, IL‐10, IL‐17, INF‐γ, EOS% and sIgE levels.

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The clinical significance of allergen-specific IgG4 in allergic diseases

Cited by 22 publications

References 98 publications

Single‐cell RNA sequencing reveals the landscape of biomarker in allergic rhinitis patient undergoing intracervical lymphatic immunotherapy and related pan‐cancer analysis

Single‐cell RNA sequencing reveals the landscape of biomarker in allergic rhinitis patient undergoing intracervical lymphatic immunotherapy and related pan‐cancer analysis

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy

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