The clinical significance of CD34 expression in response to therapy of patients with acute myeloid leukemia

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

“…Evi1 has been found to be epigenetically deregulated and associated with poor prognosis in AML [40]. CD34 is a well-established surface marker present on immature hematopoietic cells that despite having variable prognostic capacity in mixed AML backgrounds [41], is of prognostic significance within some subgroups [42,43]. Though not specifically investigated here, this may suggest a potential role for the reduction of GATA1 levels in the differentiation induced by HDAC inhibitors in AML cells [44].…”

Prognostic value of immunophenotyping and gene mutations in elderly patients with acute myeloid leukemia with normal karyotype

“…Suarez et al [26] reported that CD34-positive cells were associated with a noticeable increase in multidrug resistance and antiapoptotic phenotype, such as MDR1 (multidrug resistance protein 1) expression, which conferred resistance to chemotherapy in patients with AML. CD34 was linked with relapse and failure of treatment [13,16,27], whereas 1 study found no association with treatment efficacy [28]. Moreover, Plesa et al [15] demonstrated prognostic significance in the combination of CD33 and CD34 where an adverse outcome was associated with dual positivity or negativity of both markers.…”

Complex Measurements May Be Required to Establish the Prognostic Impact of Immunophenotypic Markers in AML

“…The prognostic value of immunophenotyping in AML has long been controversial (reviewed in Mason et al 8 ). In some studies, antigen expression was investigated as isolated reactivity, [21][22][23]28,30,[36][37][38] whereas in other reports, composite scoring systems were used. 26,[39][40][41] Technical inconsistencies should also be considered.…”