The Clinical Significance of Fever in Hodgkin's Disease

Lobell, Michael; Boggs, Dane R.; Wintrobe, M. M.

doi:10.1001/archinte.1966.03870090019004

Cited by 34 publications

(6 citation statements)

References 21 publications

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“…Cell-mediated immunity plays a role in defense against facultative intracellular bacteria (19,32), viruses (34,45), and certain other infectious agents (54, 55) and may be a significant defense against neoplastic growth (48,50). Hyperthermia is associated with certain solid and lymphoid-origin neoplasms (7,30,44) and has been shown to adversely affect neoplastic tissue to a greater extent than it does normal tissue (13,27). This effect of hyperthermia has been reported in tissue culture systems (38,43,51), in experimental animal tumors (15,22,37), and in human tumors (12,25).…”

Section: Resultsmentioning

confidence: 95%

Hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils

Roberts¹,

Steigbigel²

1977

Infect Immun

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It has recently been demonstrated that fever, or hyperthermia, results in enhanced survival of lizards infected by Aeromonas hydrophila. In the present study, the effects of hyperthermia on certain immune functions were assayed in vitro with purified human leukocytes. Lymphocyte transformation responses to the mitogen phytohemagglutinin and the common antigen streptokinase-streptodornase were enhanced at 38.5 degrees C relative to 37 degrees C whether analyzed according to absolute counts per minute of incorporated tritiated thymidine or according to stimulation indexes. Enhancement of response was not accompanied by acceleration of response. Augmentation of transformation response was generally not seen at 40 degrees C; incubation at that temperature was associated with decreased cellular viability. Significant, though small, increases of the bactericidal capacity of polymorphonuclear leukocytes at 40 degrees C relative to 37 degrees C were shown at 1 h with Escherichia coli, Salmonella typhimurium, and Listeria monocytogenes, but not with Staphylococcus aureus. Mononuclear phagocytes did not show enhanced bactericidal capacity at the elevated temperature with any of these organisms in this in vitro system. Hyperthermia may enhance certain host defense mechanisms and warrants further study.

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Section: Resultsmentioning

confidence: 95%

Hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils

Roberts¹,

Steigbigel²

1977

Infect Immun

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“…If all the potential causes of fever are excluded, the possibility of neoplastic fever should be considered. It is well known that Hodgkin's disease, nonHodgkin's lymphomas, acute leukemias, and renal cell carcinomas frequently present with neoplastic fever, but it has been observed that almost any other cancer can cause neoplastic fever [8,43]. Establishing the correct diagnosis of neoplastic fever allows for rational clinical intervention, the avoidance of unnecessary treatments and extensive diagnostic tests (thus saving medical care expenses), and provides palliation of fever-related morbidity.…”

Section: Fever In Patients With Cancermentioning

confidence: 99%

Neoplastic fever: a neglected paraneoplastic syndrome

Zell

Chang

2005

Support Care Cancer

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Neoplastic fever, a paraneoplastic syndrome caused by cancer itself, represents a diagnostic challenge for the clinician and is an important issue in supportive oncology. Timely recognition of this febrile condition by differentiating it from other cancer-associated fevers, such as infection and drug reaction, is essential for effective patient management. Although the pathophysiology of neoplastic fever is not well understood, it is suspected to be cytokine mediated. In clinical practice, when a patient with cancer presents with unexplained fever, extensive diagnostic studies are needed to differentiate neoplastic fever from nonneoplastic fever. Only after excluding identifiable etiologies of fever can the diagnosis of neoplastic fever be suspected. According to our experience, the naproxen test is a safe and useful test in differentiating neoplastic fever from infectious fever in patients with cancer. In addition, naproxen and other nonsteroidal anti-inflammatory drugs have been effective in the management of neoplastic fever and offer a significant palliative benefit for the patient.

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“…3 It is a well-described entity in patients with lymphoma, acute leukemias, and renal cell carcinoma, although almost any other cancer can cause neoplastic fever. 1,2 It is more frequently encountered in the metastatic setting, especially to the liver. 4,5 The pathophysiology of neoplastic fever remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Neoplastic fever is a well-described entity in patients with lymphoma, acute leukemias, and renal cell carcinoma, although almost any other cancer can cause neoplastic fever. 1,2 We describe an unusual case of a patient with non-small cell lung cancer (NSCLC) presenting with neoplastic fever at both diagnosis and relapse, responding on each occasion to disease-specific therapy.…”

Section: Introductionmentioning

confidence: 99%

Non-small cell lung cancer presenting with neoplastic fever at diagnosis and relapse

Zee

Soo

2010

International Journal of Infectious Diseases

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Fever occurs frequently in cancer patients, and neoplastic fever is a well-described paraneoplastic phenomenon in patients with lymphoma, acute leukemias, and renal cell carcinoma. It is also more commonly encountered in metastatic disease. Treatment options include disease-specific therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and steroids. Lung cancer is one of the most common cancers, yet fever as a manifestation of this malignancy has not been emphasized. In this report, we describe an unusual case of non-metastatic non-small cell lung cancer (NSCLC) presenting with neoplastic fever at both diagnosis and relapse, responding on each occasion to disease-specific treatment, and provide a review of the management of neoplastic fever.

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The Clinical Significance of Fever in Hodgkin's Disease

Cited by 34 publications

References 21 publications

Hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils

Hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils

Neoplastic fever: a neglected paraneoplastic syndrome

Non-small cell lung cancer presenting with neoplastic fever at diagnosis and relapse

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