The clinical significance of pneumatic tube transport system on platelet indices: <scp>EDTA</scp> or citrate anticoagulant?

Kecskemétiné, G.; Csiki, Zoltán; Mile, Melinda; Zsóri, Katalin Szilvia; Shemirani, Amir H.

doi:10.1111/ijlh.12645

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Previous studies on CBC did not find any significant difference between the two transport systems [ 3 , 7 , 9 – 11 ]. Lee et al's study [ 12 ] demonstrated statistically significantly low MPV values with PTS samples compared to hand delivered samples.…”

Section: Discussionmentioning

confidence: 73%

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests

Subbarayan

Choccalingam

Lakshmi

2018

Advances in Hematology

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Background Automation helps improve laboratory operational efficiency and reduce the turnaround time. Pneumatic tube systems (PTS) automate specimen transport between the lab and other areas of the hospital. Its effect on complete blood count (CBC) and coagulation is still controversial. Aim To study the effects of pneumatic tube system sample transport on complete blood count and coagulation parameters to compare them with hand delivered samples. Methods 75 paired samples for complete blood count and 25 paired samples for coagulation analysis were compared between samples sent via pneumatic tube system and hand delivered system. Results PTS showed significant decrease in red cell indices such as MCV and RDW and increase in MCHC. Other red cell parameters and WBC parameters showed no statistical significant difference. Statistically significant increase in platelet count was observed with PTS samples. However, these differences were clinically insignificant. No significant effect of PTS was found in PT and APTT samples compared to the hand delivered samples. Conclusion Despite statistically significant changes in RBC parameters such as MCV, RDW, and MCHC and platelet count, these changes were clinically insignificant. Hence, blood samples for CBC and coagulation assay can safely be transported via our hospital's PTS. However, further studies on platelet count are warranted to ensure safe transport and accuracy of the results.

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Section: Discussionmentioning

confidence: 73%

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests

Subbarayan

Choccalingam

Lakshmi

2018

Advances in Hematology

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Characteristics of platelet count and size and diagnostic accuracy of mean platelet volume in patients with venous thromboembolism. A systematic review and meta-analysis

Sándor

Csiki

Zsóri³

et al. 2017

Platelets

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The purpose of this study was to evaluate the association between platelet (PLT) count and mean platelet volume (MPV) and venous thromboembolism (VTE). Thus, this study reviewed and performed a quantitative synthesis on data from the literature. This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 18 studies were included in this paper. A random-effect meta-analysis was conducted for the assessment of heterogeneity using thrombosis place, type of analyzer, type of anticoagulant and incubation time of samples as covariates. A mixed-effect meta-regression was performed based on the subgroup for the whole samples using thrombosis place and method of measurement as moderators for MPV and PLT, respectively. The cumulative estimates and 95% confidence interval (95%CI) of specificity, sensitivity, area under the receiver operator characteristic curve (AUC) and diagnostic odds ratio (DOR) for MPV were calculated using a random effect model. The quality assessments were evaluated according to the quality assessment and diagnostic accuracy tool-2 (QUADAS-2). The primary outcome was the occurrence of VTE. Secondary outcomes included PLT and MPV. Patient with deep vein thrombosis is likely to have a higher value of MPV than control group (P < 0.001). The presence of pulmonary embolism (PE) had no significant effect on the standardized mean difference of MPV between patients and controls. Patients are likely to have less PLT than the control group regarding all studies. However, subgroup analysis demonstrated that this effect was significant for patients with PE (P < 0.05). The summary receiver operating characteristic (SROC) curve indicated that AUC was 0.745 (95% CI: 0.672-0.834). The DOR for MPV was 4.76 (95%CI: 2.3-9.85), with diagnostic accuracy of 0.66.

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Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Güven¹,

Doğukan²

2019

Harran Üniversitesi Tıp Fakültesi Dergisi

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272 Araştırma Makalesi / Research Article Öz. Amaç: Bu çalışmada amacımız kronik venöz yetmezlik ve varis tedavisinde siyanoakrilat (CA) ile yapılan safen ven embolizasyonunda işleme bağlı ortalama trombosit hacminin (MPV) ve trombosit sayısının değişimini saptamak ve oluşabilecek venöz tromboembolizm olaylarına açıklık getirmektir. Materyal ve Metot: Bu çalışmaya dâhil edilen 60 hasta Adıyaman Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisine Polikliniğine başvuran varis ve kronik venöz yetersizliği olan hastalardan seçildi. CA ile safen ven embolizasyonu yapılan hastaların dosya taraması dijital ortamda yapılarak USG ve laboratuvar tetkikleri incelendi. İşlem yapılan toplam 437 hastadan işlem öncesi ve sonrası hemogram ve biyokimya tetkikleri alınan60hasta çalışmaya dahil edildi. Hastaların işlem öncesi ve sonrası trombosit sayısı ve ortalama trombosit hacmi değerlendirildi. Bulgular: Postoperatif(post-op) 1. Saat ve 1.ay MPV değeri preoperatif (pre-op) döneme göre anlamlı (p ˃ 0.05) değişim göstermezken post-op 3.gün MPV değeri pre-op döneme göre anlamlı (p ˂ 0.05) artış gösterdiği tespit edildi. Post-op 3.gün MPV değeri post op 1.saate göre anlamlı (p ˂ 0.05) artış ve post-op 1.ay MPV değeri post-op 3.güne göre anlamlı (p ˂ 0.05) düşüş göstermiştir. Sonuç: MPV işlemden 1 gün sonra normal değerlerden anlamlı artış göstermez iken post op 3. günde anlamlı artış gösterdi. MPV'ün artan trombojenite ile ilişkili olduğunu varsayarsak varis tedavisinde kullanılan minimal invaziv yöntemlerden olan CA ile safen ven embolizasyonu post-op erken (İlk bir hafta içinde) dönemde tromboembolik olaylara sebep olabilmektedir. AbstractBackground: In the present study, it is aimed to determine the intervention-related change in the mean platelet volume (MPV) and platelet count in saphenous vein embolization performed using cyanoacrylate in chronic venous stasis and varicose treatment, as well as explaining the possible venous thromboembolism events. Methods: 60 patients involved in the present study were selected from the patients, who had varicose and chronic venous stasis and who applied to the Cardiovascular Surgery Polyclinic of Medical Faculty of Adıyaman University. The files of patients undergone saphenous vein embolization using CA were performed digitally and their USG and laboratory results were analyzed. Among 437 patients, 60 patients' undergone hemogram and biochemical examination before and after the intervention were involved in the present study. The preoperative (pre-op) and postoperative (post-op) platelet counts and mean platelet volumes of the patients were analyzed. Results: When compared to the pre-op period, no significant change was observed on 1 st post-ophour and 1 st post-op month (p ˃ 0.05), however the MPV value observed on the 3 rd post-op day was significantly higher than the pre-op period (p ˂ 0.05). The MPV value observed on the 3 rd post-op day was statistically higher than on 1 st post-op hour (p ˂ 0.05) and the MPV value observed on the 1 st post-op month was statistically significantly lowe...

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The clinical significance of pneumatic tube transport system on platelet indices: EDTA or citrate anticoagulant?

Cited by 3 publications

References 18 publications

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests

Characteristics of platelet count and size and diagnostic accuracy of mean platelet volume in patients with venous thromboembolism. A systematic review and meta-analysis

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

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