The clinical spectrum of IgG4-related disease

Synovitis in a Patient with IgG4-related Disease

“…Arthralgia occurs in approximately 10% of patients with IgG4-RD (9), whereas IgG4-related arthritis with joint swelling is extremely rare (5,6). To the best of our knowledge, only three such cases have been reported (10)(11)(12).…”

“…The pancreas is the first organ reported in the context of IgG4-RD (4), although the disease can also affect the salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, aorta, prostate and other organs (2,3). However, joint involvement in IgG4-RD is rare (5,6). Therefore, the findings of radiological assessments of IgG4-related arthritis using magnetic resonance imaging ( MRI ) or 18 Ffluorodeoxyglucose positron emission tomography (FDG-PET) have rarely been reported.…”

Peripheral plasmablasts in anti-MuSK myasthenia gravis

“…We believe that the study of the ties between IgG4-mediated neurological autoimmune disorders and IgG4-related disease could represent a very fruitful field in the near future [10] , so further studies are needed in this specific area. However, one of the limitations that these studies might face is the low prevalence (or underdiagnosis) of these conditions [11,12] . Multicentric studies through international, collaborative efforts could mitigate this limitation.…”

IgG4 Syndrome Presenting as Leptomeningitis in a Young Woman

“…Such neurological deficits reflect mechanical compression of nerve structures, leading to neurological deficits 7 8 if biopsy is contraindicated, technically risky, or uninformative. All the patients with IHP had elevated serum levels of IgG4.…”