The Clinical Stability of Serum Cholinesterase Activity

Wetstone, Howard J.; LaMotta, Rudolph V.

doi:10.1093/clinchem/11.6.653

Cited by 33 publications

(4 citation statements)

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“…Serum cholinesterase activity has been known to remain relatively constant in each individual. The standard deviation of benzoylcholine activity was equal to 7.3% of the mean activity, which is quite similar to that of 8.4% reported by Wetstone and LaMotta (1965). The concentration of enzyme protein and specific activity also showed little variability (6.9 and 9.9%, respectively).…”

Section: Quantitation Of Serum Cholinesterasesupporting

confidence: 86%

Immunological comparison of the usual and atypical human serum cholinesterase phenotypes

et al. 1983

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Antiserum prepared against highly purified usual human serum cholinesterase (the most common phenotype) cross-reacted identically with the atypical serum cholinesterase. The level of circulating atypical enzyme protein, determined immunologically, was about 30% lower when the enzyme came from an atypical rather than a usual phenotype, and the level of enzyme activity measured enzymatically at Vmax with either o-nitrophenylbutyrate or benzoylcholine as substrate showed approximately the same degree of reduction. The average specific activity (activity at Vmax per microgram of enzyme protein) in sera from 28 usual and 20 atypical individuals did not differ significantly. These findings suggest that the atypical enzyme not only has altered catalytic properties (Km) but also might be synthesized more slowly, or cleared in vivo more rapidly, than the usual enzyme.

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Section: Quantitation Of Serum Cholinesterasesupporting

confidence: 86%

Immunological comparison of the usual and atypical human serum cholinesterase phenotypes

et al. 1983

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“…Rattner & Fairbrother (1991) reported that serum cholinesterase activities depended on the reproductive status of the birds. Serum cholinesterase was reported to be very stable in healthy human individuals not exposed to pollutants, with a CV of 8.4% in 82 individuals tested 373 times over a period of 1-250 weeks (Wetstone & LaMotta 1965), and variation between individuals was greater than within individuals (Sawitsky et al 1948). The fact that both total cholinesterase and GSH-Px varied little during periods of 45 days (or even longer as one season), suggests that they are reliable indicators of an individuals' health, as they seem to reflect relatively long-term components of an individuals physiology, than other studied parameters (with exception of WBC and H/L).…”

Section: Repeatabilities Of Great Tit Blood Parameters Between Recaptmentioning

confidence: 99%

Repeatability and Method-Dependent Variation of Blood Parameters in Wild-Caught Great TitsParus major

Norte¹,

Sheldon²,

Sousa³

et al. 2008

Acta Ornithologica

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When interpreting responses to experimental manipulations or particular environmental cues, it is necessary to have previous knowledge about the natural variation of the response traits. We studied how nine blood parameters, including four enzymatic activities, varied with time in wild Great Tits by assessing their repeatabilities over periods of 45 days, in the same season (Spring or Autumn/Winter), in the same year and over a four years period. The accuracy of the measurements of these blood parameters was also assessed. Measurement error reflected essentially sample and time of storage rather than assay effects. Hematocrit and haemoglobin had low repeatabilities within Spring, ranging from 0.26 to 0.31; Heterophil/Lymphocyte ratio (H/L), white blood cell count (WBC), total plasma cholinesterase and red blood cell glutathione peroxidase (GSH-Px) activities had moderate to high repeatabilities over periods of 45 days (repeatabilities ranged from 0.47 to 0.81 for GSH-Px and H/L, respectively), but also during longer periods such as during Spring (total plasma cholinesterase activity) and Autumn/Winter (WBC, H/L and GSH-Px). Of the blood parameters measured, total plasma cholinesterase, glutathione peroxidase and the haematological parameters WBC and H/L seem relatively constant and therefore reliable indicators of Great Tit's physiological condition within, at least, a 45 days time frame.

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“…However, the rate of return are variable among different tissues. 9 Oxime possesses the functions of removing the nerve agents from the enzymes and reactivating the enzymes unless "aging" has occurred. "Aging" is a biochemical reaction between the agent and the enzyme complex.…”

Section: Toxicodynamicsmentioning

confidence: 99%

A Review Article on Nerve Agents

Tang¹,

Chan²

2002

Hong Kong Journal of Emergency Medicine

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The incidence of Tokyo subway attack by the Aum Shinrikyo cult in 1995 had raised the concern of the use of nerve agent as a weapon in terrorist attack. The recent event in World Trade Centre in New York city had further brought our attention to the possibility of terrorist attacks using these agents. In view of the high possibility of nerve agents being used as chemical weapon, medical personnel should have a clear knowledge of these agents. This article aim to provide a detailed discussion of these agents.

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The Clinical Stability of Serum Cholinesterase Activity

Cited by 33 publications

References 0 publications

Immunological comparison of the usual and atypical human serum cholinesterase phenotypes

Immunological comparison of the usual and atypical human serum cholinesterase phenotypes

Repeatability and Method-Dependent Variation of Blood Parameters in Wild-Caught Great TitsParus major

A Review Article on Nerve Agents

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