The clinical trial on the safety and effectiveness of the photodynamic diagnosis of non-muscle-invasive bladder cancer using fluorescent light-guided cystoscopy after oral administration of 5-aminolevulinic acid (5-ALA)

Inoue, Keiji; Matsuyama, Hideyasu; Fujimoto, Kiyohide; Hirao, Yoshihiko; Watanabe, Hironobu; Ozono, Seiichiro; Oyama, Masafumi; Ueno, Munehisa; Sugimura, Yoshiki; Shiina, Hìroaki; Mimata, Hiromitsu; Azuma, Haruhito; Nagase, Yasushi; Matsubara, Akio; Ito, Yoichi M.; Shuin, Taro

doi:10.1016/j.pdpdt.2015.12.011

Cited by 40 publications

(27 citation statements)

References 12 publications

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“…The Kaplan-Meier survival curves were compared using the log-rank test, also known as the Mantel-Haenszel or Mantel-Cox test [27]. The test statistics relies on the differences between the observed and expected number of events (i.e.…”

Section: Methodsmentioning

confidence: 99%

5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression

et al. 2016

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Aim of the present study was to analyze the oncological impact of 5-ALA fluorescence of cerebral metastases. A retrospective analysis was performed for 84 patients who underwent 5-ALA fluorescence-guided surgery of a cerebral metastasis. Dichotomized fluorescence behavior was correlated to the histopathological subtype and primary site of the metastases, the degree of surgical resection on an early postoperative MRI within 72 hours after surgery, the local in-brain-progression rate and the overall survival. 34/84 metastases (40.5%) showed either strong or faint and 50 metastases (59.5%) no 5-ALA derived fluorescence. Neither the primary site of the cerebral metastases nor their subtype correlated with fluorescence behavior. The dichotomized 5-ALA fluorescence (yes vs. no) had no statistical influence on the degree of surgical resection. Local in-brain progression within or at the border of the resection cavity was observed in 26 patients (30.9%). A significant correlation between 5-ALA fluorescence and local in-brain-progression rate was observed and patients with 5-ALA-negative metastases had a significant higher risk of local recurrence compared to patients with 5-ALA positive metastases. After exclusion of the 20 patients without any form of adjuvant radiation therapy, there was a trend towards a relation of the 5-ALA behavior on the local recurrence rate and the time to local recurrence, although results did not reach significance anymore. Absence of 5-ALA-induced fluorescence may be a risk factor for local in-brain-progression but did not influence the mean overall survival. Therefore, the dichotomized 5-ALA fluorescence pattern might be an indicator for a more aggressive tumor.

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Section: Methodsmentioning

confidence: 99%

5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression

et al. 2016

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“…Herein, we reported a case, in which a BT that had invaded the ureteral orifice was resected via PDD‐TUR‐BT involving the oral, rather than intravesical, administration of 5‐ALA. In Japan, oral‐PDD‐TUR‐BT was approved by the Ministry of Health, Labor, and Welfare in December 2017 based on several clinical trials, which demonstrated the safety and effectiveness of oral‐PDD‐TUR‐BT . It has been reported that PDD exhibits sensitivity and specificity of 79.6% and 80.6%, respectively, for detecting NMIBC .…”

Section: Discussionmentioning

confidence: 99%

A case in which bladder cancer invaded the ureteral orifice and was resected via photodynamic diagnosis‐assisted transurethral resection involving orally administered 5‐aminolevulinic acid

et al. 2019

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Introduction Transurethral resection of bladder tumor is widely used in combination with photodynamic diagnosis to treat non‐muscle invasive bladder cancer. We experienced an intriguing case, in which bladder cancer infiltrated into the right ureteral orifice and was resected via photodynamic diagnosis‐assisted transurethral resection involving the oral administration of 5‐aminolevulinic acid. Case presentation This case was a 71‐year‐old Japanese man. He was diagnosed with bladder carcinoma, which had infiltrated into the right ureter (clinical classification: T1, N0, M0). He underwent transurethral resection involving the oral administration of 5‐aminolevulinic acid. We successfully resected the tumor in the ureteral orifice, which was accomplished by resecting the ureteral orifice until the non‐luminescent lumen was exposed. After the surgery, to prevent recurrence, Bacillus Calmette–Guérin was administered intravesically after right ureteral stent placement. Conclusion Photodynamic diagnosis‐assisted transurethral resection involving the oral administration of 5‐aminolevulinic acid has the potential to treat ureteral tumors derived from bladder tumors.

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“…With the help of photosensitizer, such as 5‐ALA and its derivative HAL, the fluorescence cystoscopy has a higher diagnostic rate for CIS, flat or papillary cancerous nidus. Its intraoperative application can improve the overall resection rates of the tumor . A multicenter research reported by Palou et al pointed out that with the assist of blue light, white light cystoscopy would have an obviously elevated rate of early diagnosis of NMIBC (especially for CIS and Ta stage) .…”

Section: Research Front Of Precision Diagnosis In Bladder Cancermentioning

confidence: 99%

Hope and challenge: Precision medicine in bladder cancer

Jiang

Tao

et al. 2019

Cancer Medicine

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Bladder cancer (BC) is a complex disease and could be classified into nonmuscle‐invasive BC (NMIBC) or muscle‐invasive BC (MIBC) subtypes according to the distinct genetic background and clinical prognosis. Until now, the golden standard and confirmed diagnosis of BC is cystoscopy and the major problems of BC are the high rate of recurrence and high costs in the clinic. Recent molecular and genetic studies have provided perspectives on the novel biomarkers and potential therapeutic targets of BC. In this article, we provided an overview of the traditional diagnostic approaches of BC, and introduced some new imaging, endoscopic, and immunological diagnostic technology in the accurate diagnosis of BC. Meanwhile, the minimally invasive precision treatment technique, immunotherapy, chemotherapy, gene therapy, and targeted therapy of BC were also included. Here, we will overview the diagnosis and therapy methods of BC used in clinical practice, focusing on their specificity, efficiency, and safety. On the basis of the discussion of the benefits of precision medicine in BC, we will also discuss the challenges and limitations facing the non‐invasive methods of diagnosis and precision therapy of BC. The molecularly targeted and immunotherapeutic approaches, and gene therapy methods to BC treatment improved the prognosis and overall survival of BC patients.

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The clinical trial on the safety and effectiveness of the photodynamic diagnosis of non-muscle-invasive bladder cancer using fluorescent light-guided cystoscopy after oral administration of 5-aminolevulinic acid (5-ALA)

Cited by 40 publications

References 12 publications

5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression

5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression

A case in which bladder cancer invaded the ureteral orifice and was resected via photodynamic diagnosis‐assisted transurethral resection involving orally administered 5‐aminolevulinic acid

Hope and challenge: Precision medicine in bladder cancer

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