The Clinical Use of Curcumin for the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Clinical Trials

Gharibpour, Fateme; Fakheran, Omid; Parvaneh, Alireza; Shirban, Farinaz; Bagherniya, Mohammad; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1007/978-3-030-56153-6_13

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Second, with the development of oral mucositis, pain relief often requires analgesic medication (Bardy et al., 2012); therefore, nonpharmacological interventions may appear less effective. However, considering that certain natural plants also have analgesic characteristics (Gharibpour et al., 2021), and that health education can provide medication guidance to cope with pain, nurses may regard these two measures as complementary treatments for helping patients relieve severe oral mucositis‐related pain.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Zhang,

Li,

Zhang

et al. 2024

Journal of Clinical Nursing

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Aims and ObjectivesTo assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head and neck cancer.BackgroundRadiation‐induced oral mucositis is highly prevalent in patients with head and neck cancer. Current medications for radiation‐induced oral mucositis are limited in effectiveness and susceptible to side effects, and while there is an increasing adoption of nonpharmacological interventions, the optimal one remains unclear.DesignSystematic review and network meta‐analysis based on the PRISMA‐NMA guidelines.MethodsSix databases were searched. Two authors independently performed the literature screening, data extraction and methodological quality assessment of the included studies. Traditional pairwise meta‐analysis was performed by R Studio. A network meta‐analysis was then conducted to assess the effects of nonpharmacological interventions for severe radiation‐induced oral mucositis in patients with head and neck cancer.ResultsFifty‐two studies involving seven types of nonpharmacological interventions were enrolled. The network meta‐analysis indicated that natural plant‐based therapies might be the most effective, health education interventions might be the second most effective, and honey might be the third most effective interventions for reducing the incidence of severe radiation‐induced oral mucositis. For reducing the incidence of severe oral mucositis‐related pain, the pairwise meta‐analysis showed that only natural plant‐based therapies and health education interventions were effective.ConclusionsNonpharmacological interventions are effective in the management of severe radiation‐induced oral mucositis among patients with head and neck cancer.Relevance to clinical practiceNonpharmacological interventions are a category of safe and effective adjunctive therapies that should be encouraged in clinical practice.Trial registration detailsCRD42023400745.

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Section: Discussionmentioning

confidence: 99%

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Zhang,

Li,

Zhang

et al. 2024

Journal of Clinical Nursing

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“…The scarcity of studies in this field doubles the importance of identifying and introducing effective and safe TCIM treatments to The idea of assessing honey-lime in the form of a randomized clinical trial was taken from PM, though the use of ethnopharmacology to introduce novel agents for treating common diseases has a long history [29,30]. Various in vitro and in vivo studies have been conducted to determine the efficacy of different components of natural or herbal compounds, followed by randomized clinical trials [31][32][33][34]. Also, some laboratory and animal studies have been conducted on xerostomia [35,36], but precise randomized clinical trials with placebo and crossover groups seem necessary considering the current state of available data [27].…”

Section: Discussionmentioning

confidence: 99%

Effect of Honey-Lime Spray as Add-On Therapy on Chemotherapy-Induced Xerostomia in Breast Cancer Patients: A Pilot Randomized Double-Blinded Controlled Trial

Heydarirad,

Mirzaei,

Gharehgozlou

et al. 2024

Complement Med Res

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Introduction: Xerostomia (dry mouth) is a common side effect among patients with cancer undergoing chemotherapy. There is no standard treatment for this symptom yet, although Persian medicine textbooks suggested some products to relieve xerostomia. We aimed to assess the efficacy of Honey-lime spray in treating chemotherapy-induced xerostomia in breast cancer patients through a controlled study. Methods: In this pilot, randomized, double-blinded clinical trial conducted in Shohadaye Tajrish Hospital, Iran, the intervention group received Honey-lime spray and nystatin, while the control group used distilled water plus nystatin for two weeks. The six-item dry mouth form and visual analog score (VAS) were used to evaluate xerostomia extent and pain, respectively. Results: The standardized value of the difference between the mean scores before and after the study was -10.21 (P<0.001), and the effect size was estimated at 55%. Also, VAS showed a significant decrease in pain for the intervention group compared with the control group (P<0.001). There were no serious side effects. Conclusion: Honey-lime spray may be a good treatment choice for xerostomia in chemotherapy-induced breast cancer patients, but robust trials with larger samples and prolonged follow-ups are highly recommended.

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“…A very recent systematic review indicated the beneficial effects of curcumin on various conditions, including renal and prostate diseases, oral and dental diseases, osteoarthritis, rheumatoid arthritis, neurological diseases, gastrointestinal diseases, psychological conditions, epilepsy and non‐alcoholic fatty liver diseases (NAFLD) (Atefi et al, 2021; Bagherniya et al, 2021; Bagherniya et al, 2021; Bagherniya et al, 2021; Bishnoi, Chopra, Rongzhu, & Kulkarni, 2011; Ehteshami et al, 2021; Fakheran et al, 2021; Gharibpour et al, 2021; Jalali et al, 2020; Mohseni et al, 2021; Shirban et al, 2021; Shokri‐Mashhadi, Bagherniya, Askari, Sathyapalan, & Sahebkar, 2021; Xu et al, 2018). In addition, Curcumin has various antioxidant and anti‐inflammatory activities, which play a substantial role in the beneficial effects observed in clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Heidari

Bagherniya

Majeed

et al. 2023

Phytotherapy Research

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Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti‐inflammatory and anti‐oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co‐administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin‐piperine co‐supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin‐piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID‐19. Further high‐quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin‐piperine supplement.

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The Clinical Use of Curcumin for the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Clinical Trials

Cited by 4 publications

References 46 publications

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Effect of Honey-Lime Spray as Add-On Therapy on Chemotherapy-Induced Xerostomia in Breast Cancer Patients: A Pilot Randomized Double-Blinded Controlled Trial

Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

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