The Clinical Use of Genomic Profiling for Prognosis Prediction in High Grade Serous Ovarian Cancer

Abstract

The majority of ovarian cancer cases are high-grade serous ovarian cancers (HGSOC). HGOSC harbors several genomic alterations that play crucial roles in carcinogenesis. Studies on the molecular characterization of HGSOC have suggested that HGSOC is a heterogenous disease, rather than a singular disease entity. Genomic profiling using gene expressions, methylation patterns, and non-coding RNA expression patterns have all been used as the basis for the molecular categorization of HGSOC. Understanding these classifications in relationship to the prognosis, such as overall survival, progression-free survival, and response to chemotherapy, is crucial in the age of precision medicine in order to direct specialized or targeted treatment and improve the prognosis. Research in the future will concentrate on creating therapies targeted at certain molecular subtypes.